Dietary conjugated linoleic acid isomers and
selenium affect the fatty acid profile in rat liver

The inﬂuence of dietary conjugated linoleic acid (CLA) isomers and/or Se (as Na₂Se0₄) on the content of CLA isomers and other fatty acids (FAs) in rat liver was investigated. Feeding CLA isomers resulted in an elevated hepatic CLA isomer content. The diet with Se and cis9trans11 CLA most effectively elevated the liver content of cis9 trans11, cis,tras/trans,cis, the sum of CLA isomers, C20:4 and C20:6. Adding Se, cis9trans11CLA or a CLA isomer mixture decreased the capacity of Δ6-, Δ5-desaturases and elongase, while trans10cis12 had the opposite effect. Feeding Se or CLA isomers reduced Δ9-desaturase capacity.

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