ORIGINAL PAPER
Immune stress up regulates TLR4 and Tollip gene expression in the hypothalamus of ewes
 
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1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
2
The Academy of Cosmetics and Health Care in Warsaw, 00-252 Warsaw, Poland
CORRESPONDING AUTHOR
A. P. Herman   

The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
Publication date: 2013-03-18
 
J. Anim. Feed Sci. 2013;22(1):13–18
 
KEYWORDS
ABSTRACT
Bacterial endotoxin, LPS, is recognized by Toll-like receptor-4 (TLR4) and induces a signaling cascade leading to synthesis of proinflammatory cytokines and induction of sickness behavior in animals. Transduction of the TLR4 signal is controlled by a potent negative regulator—Toll-interacting protein. The presented study concerns the effect of intravenously injected LPS on the level of expression of TLR4 and Tollip genes in the hypothalamus of ewes. Endotoxin increased (P < 0.01) cortisol release and expression of TLR4 and Tollip genes in the preoptic area (1.87 ± 0.42 and 1.31 ± 0.15), anterior hypothalamus (1.77 ± 0.22 and 1.27 ± 0.13), medial basal hypothalamus (2.53 0.65 and 1.43 ± 0.15), and median eminence (2.93 ± 0.46 and 1.73 ± 0.10), respectively, in comparison with non-treated animals. Our results show that immune stress increases TLR4 gene expression in the hypothalamus. Increased transcription of Tollip may be an attempt to reduce the effect of TLR4 stimulation.
 
CITATIONS (9):
1.
Identification, characterization and expression profiling of the Tollip gene in Yesso scallop (Patinopecten yessoensis)
Ru Zhang, Ruojiao Li, Jing Wang, Shuyue Wang, Mengran Zhang, Xiaoli Hu, Lingling Zhang, Shi Wang, Ruijia Wang, Zhenmin Bao
Genes & Genetic Systems
 
2.
Effects of Central Injection of Anti-LPS Antibody and Blockade of TLR4 on GnRH/LH Secretion during Immunological Stress in Anestrous Ewes
Karolina Haziak, Andrzej Przemysław Herman, Dorota Tomaszewska-Zaremba
Mediators of Inflammation
 
3.
Plasma and cerebrospinal fluid interleukin-1β during lipopolysaccharide-induced systemic inflammation in ewes implanted or not with slow-release melatonin
Janina Skipor, Marta Kowalewska, Aleksandra Szczepkowska, Anna Majewska, Tomasz Misztal, Marek Jalynski, Andrzej P. Herman, Katarzyna Zabek
Journal of Animal Science and Biotechnology
 
4.
Melatonin from slow-release implants did not influence the gene expression of the lipopolysaccharide receptor complex in the choroid plexus of seasonally anoestrous adult ewes subjected or not to a systemic inflammatory stimulus
M. Kowalewska, A. Szczepkowska, A.P. Herman, M.T. Pellicer-Rubio, M. Jałyński, J. Skipor
Small Ruminant Research
 
5.
How does bacterial endotoxin influence gonadoliberin/gonadotropins secretion and action?
D. Tomaszewska-Zaremba, A. Herman, K. Haziak
Journal of Animal and Feed Sciences
 
6.
Characterizations and expression analyses of NF-κB and Rel genes in the Yesso scallop (Patinopecten yessoensis) suggest specific response patterns against Gram-negative infection in bivalves
Ruojiao Li, Ru Zhang, Lu Zhang, Jiajun Zou, Qiang Xing, Huaiqian Dou, Xiaoli Hu, Lingling Zhang, Ruijia Wang, Zhenmin Bao
Fish & Shellfish Immunology
 
7.
Effect of CD14/TLR4 antagonist on GnRH/LH secretion in ewe during central inflammation induced by intracerebroventricular administration of LPS
Karolina Haziak, Andrzej Przemysław Herman, Karolina Wojtulewicz, Bartosz Pawlina, Kamila Paczesna, Joanna Bochenek, Dorota Tomaszewska-Zaremba
Journal of Animal Science and Biotechnology
 
8.
Innate immunity and inflammation of the bovine female reproductive tract in health and disease
I Sheldon, James Cronin, Gareth Healey, Christoph Gabler, Wolfgang Heuwieser, Dominik Streyl, John Bromfield, Akio Miyamoto, Chrys Fergani, Hilary Dobson
REPRODUCTION
 
9.
Lipopolysaccharide Regulates Pro- and Anti-Inflammatory Cytokines, Corticosterone, and Melatonin in Toads
L Ferreira, Neto Garcia, S Titon, B Titon, S Muxel, F Gomes, V Assis
Integrative Organismal Biology
 
ISSN:1230-1388