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Photoperiodic conditions as a factor modulating leptin influence on pro-inflammatory cytokines and their receptors gene expression in ewe’s aorta

A. Krawczyńska 1  ,  
H. Antushevich 1,  
J. Bochenek 1,  
K. Wojtulewicz 1,  
B. Pawlina 1,  
A. P. Herman 1,  
D. A. Zięba 2
 
1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Department of Genetic Engineering, Instytucka 3, 05-110 Jabłonna
2
Agricultural University of Krakow, Department of Animal Biotechnology, Laboratory of Biotechnology and Genomics, 30-248 Krakow, Poland
J. Anim. Feed Sci. 2019;28(2):128–137
Publish date: 2019-06-19
DOI: https://doi.org/10.22358/jafs/110022/2019
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References (43) Citations (1)
 
KEYWORDS
aorta, cytokines, ewes, leptin, lipopolysaccharide, photoperiod
TOPICS
endocrinology, sheep & goats, physiology
ABSTRACT
Atherosclerosis, a chronic inflammation state of the aorta, is characterised by increased levels of pro-inflammatory cytokines (tumour necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-6). Sheep is used in both cardiovascular and immunological studies; besides, ‘long-day’ ewe can be a model of leptin resistance state. The aim of the study was to examine whether photoperiodic conditions (long-day (LD) and short-day (SD) seasons) are a key factor modulating exogenous leptin influence on pro-inflammatory cytokines and their receptors gene expression in aorta of ewe’s with or without prior induction of acute inflammation. The experiment was conducted on 48 ewes during SD and LD seasons which were randomly divided into 4 groups: control; with LPS injection (400 ng/kg of body weight (BW)); with leptin injection (20 μg/kg BW); and with LPS and 30-min later leptin injection. Three hours after LPS/control treatment animals were euthanized to collect the thoracic aorta samples. In both seasons leptin injection intensified LPS-induced increase in IL1B gene expression but only in SD season leptin injection increased IL1R1 and IL1R2 gene expressions. The leptin injection increased IL6 gene expression but only in SD season. In the LD season leptin enhanced the LPS effect on IL6 gene expression. Neither TNFA nor its receptors gene expression was influenced by leptin regardless of season. In the thoracic aorta tissue an exogenous leptin exerts effect on pro-inflammatory cytokines and their receptors gene expression; however in ewe this influence depends on photoperiodic conditions. Moreover, leptin can moderate progression of the inflammation reaction in this tissue
CORRESPONDING AUTHOR
A. Krawczyńska   
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Department of Genetic Engineering, Instytucka 3, 05-110 Jabłonna
 
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CITATIONS (1):
1. Effect of Central Injection of Neostigmine on the Bacterial Endotoxin Induced Suppression of GnRH/LH Secretion in Ewes during the Follicular Phase of the Estrous Cycle
Andrzej Herman, Janina Skipor, Agata Krawczyńska, Joanna Bochenek, Karolina Wojtulewicz, Bartosz Pawlina, Hanna Antushevich, Anna Herman, Dorota Tomaszewska-Zaremba
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