ORIGINAL PAPER
Does central IL-1β affect GnRH secretion in the hypothalamus of anoestrous ewes via different regulatory pathways?
| 1 | The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna Poland |
CORRESPONDING AUTHOR
D. Tomaszewska-Zaremba
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna Poland
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna Poland
Publication date: 2013-03-22
J. Anim. Feed Sci. 2013;22(1):5–12
KEYWORDS
ABSTRACT
The study was designed to identify the central pathways through
which central interleukin-1β (IL-1β) affects gonadotropin-releasing hormone
(GnRH) release in anoestrous ewes. Our results show that intracerebroventricular
(icv.) injection of IL-1β (50 μg) decreases the GnRH concentration in the
perfusates collected from the medial basal hypothalamus/median eminence
(MBH/ME), increases its type I receptor gene expression in the preoptic
area, anterior hypothalamus (AHA) and medial basal hypothalamus, and
significantly decreases the neuropeptide Y (NPY) mRNA level in the AHA and
MBH. No effect of IL-1β treatment was found on plasma cortisol concentration,
catecholamine (norepinephrine and dopamine) levels in perfusates, as well as
cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) gene expression in
the hypothalamus. Our data demonstrate that central IL-1β suppresses GnRH
release mainly by acting directly through its own hypothalamic receptors, and
its effect could be, at least partially, caused by changes in the NPY level, which
is known as an important modulator of GnRH biosynthesis and release.
CITATIONS (6):
1.
Effects of Central Injection of Anti-LPS Antibody and Blockade of TLR4 on GnRH/LH Secretion during Immunological Stress in Anestrous Ewes
Karolina Haziak, Andrzej Przemysław Herman, Dorota Tomaszewska-Zaremba
Mediators of Inflammation
Karolina Haziak, Andrzej Przemysław Herman, Dorota Tomaszewska-Zaremba
Mediators of Inflammation
2.
How does bacterial endotoxin influence gonadoliberin/gonadotropins secretion and action?
D. Tomaszewska-Zaremba, A. Herman, K. Haziak
Journal of Animal and Feed Sciences
D. Tomaszewska-Zaremba, A. Herman, K. Haziak
Journal of Animal and Feed Sciences
3.
Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation
Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor
Mediators of Inflammation
Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor
Mediators of Inflammation
4.
Effect of Central Injection of Neostigmine on the Bacterial Endotoxin Induced Suppression of GnRH/LH Secretion in Ewes during the Follicular Phase of the Estrous Cycle
Andrzej Herman, Janina Skipor, Agata Krawczyńska, Joanna Bochenek, Karolina Wojtulewicz, Bartosz Pawlina, Hanna Antushevich, Anna Herman, Dorota Tomaszewska-Zaremba
International Journal of Molecular Sciences
Andrzej Herman, Janina Skipor, Agata Krawczyńska, Joanna Bochenek, Karolina Wojtulewicz, Bartosz Pawlina, Hanna Antushevich, Anna Herman, Dorota Tomaszewska-Zaremba
International Journal of Molecular Sciences
5.
The Influence of Anandamide on the Anterior Pituitary Hormone Secretion in Ewes—Ex Vivo Study
Dorota Tomaszewska-Zaremba, Karolina Wojtulewicz, Kamila Paczesna, Monika Tomczyk, Katarzyna Biernacka, Joanna Bochenek, Andrzej Herman
Animals
Dorota Tomaszewska-Zaremba, Karolina Wojtulewicz, Kamila Paczesna, Monika Tomczyk, Katarzyna Biernacka, Joanna Bochenek, Andrzej Herman
Animals
6.
Anandamide Influences Interleukin-1β Synthesis and IL-1 System Gene Expressions in the Ovine Hypothalamus during Endo-Toxin-Induced Inflammation
Monika Tomczyk, Dorota Tomaszewska-Zaremba, Joanna Bochenek, Anna Herman, Andrzej Herman
Animals
Monika Tomczyk, Dorota Tomaszewska-Zaremba, Joanna Bochenek, Anna Herman, Andrzej Herman
Animals
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