ORIGINAL PAPER
Effects of three-month feeding high-fat diets with different
fatty acid composition on kidney histology and expression
of genes related to cellular stress and water-electrolyte
homeostasis in mice
1
West Pomeranian University of Technology, Faculty of Biotechnology and Animal Husbandry, Department of Physiology,
Cytobiology and Proteomics, 71-270 Szczecin, Poland
2
Bydgoszcz University of Science and Technology, Faculty of Animal Breeding and Biology, Department of Animal Biotechnology
and Genetics, 85-084 Bydgoszcz, Poland
3
Pomeranian Medical University, Faculty of Health Sciences, Department of Histology and Developmental Biology,
71-210 Szczecin, Poland
4
Institute of Biochemistry and Biophysics, Polish Academy of Sciences,
Laboratory of Molecular Basis of Aging and Rejuvenation, 02-106 Warsaw, Poland
5
Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Department of Genomics and Biodiversity,
05-552 Magdalenka, Poland
Publication date: 2023-06-22
Corresponding author
A. Wypych
West Pomeranian University of Technology, Faculty of Biotechnology and Animal Husbandry, Department of Physiology, Cytobiology and Proteomics, 71-270 Szczecin, Poland
West Pomeranian University of Technology, Faculty of Biotechnology and Animal Husbandry, Department of Physiology, Cytobiology and Proteomics, 71-270 Szczecin, Poland
J. Anim. Feed Sci. 2023;32(4):372-384
KEYWORDS
TOPICS
ABSTRACT
The Western diet, which is typically high in saturated fatty
acids (SFAs) and low in n-3 polyunsaturated fatty acids (PUFAs), has been
identified as a factor contributing to the growing obesity rate. Long-term
consumption of high-fat diets (HFDs) has also been associated with increased
risk of chronic kidney disease. Therefore, we hypothesized that different fatty
acids composition in HFDs would differentially affect renal microstructure and
expression pattern of selected genes. Swiss-Webster male mice (n = 24)
were fed a standard chow for mice (STD) or HFDs rich in SFAs, and rich in
PUFA with a linoleic acid (LA) to α-linolenic acid (ALA) ratio of 14:1 (HR) or
5:1 (LR) for 3 months. We observed that both the SFA and HR groups had
increased epithelial cell vacuolisation, collagenous tissue area and number
of TUNEL-positive cells, accompanied by elevated Kim-1 expression in the
kidneys. Sod1 and Cat were up-regulated, while Cox2 was down-regulated
in the kidneys of HR mice when compared to the STD group. Both PUFArich
HFDs down-regulated the Ren1 and Agt genes. The HR diet also caused
an increased deposition of AQP2 in the basolateral membrane (BLM) and
intracellular space of collecting duct (CD) cells. In both the HR and SFA groups,
an increased expression of the Aqp3 gene and AQP3 protein in CD cells was
observed. In conclusion, the findings suggest that higher levels of ALA in the
HFD were associated with a reduction in the severity of renal tissue lesions.
Diets rich in SFAs or LA have the potential to modify the renal mechanism of
facultative urine concentration by altering the expression and/or distribution of
AQP2 and AQP3 in the kidneys.
FUNDING
This work received financial support from two sources. The dietary experiment was conducted with the support of KNOW (Leading National Research Centre) Scientific Consortium “Healthy Animal – Safe Food”, decision of the Ministry of Science and Higher Education No. 05-1/KNOW2/2015”, grant no. KNOW2015/CB/PRO1/44. The analyses performed were supported by The Rector of the West Pomeranian University of Technology in Szczecin for PhD students of The Doctoral School, grant no. 35/2022.
CONFLICT OF INTEREST
The Authors declare that there is no conflict of interest.
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Journal of Animal and Feed Sciences
| ISSN: | 1230-1388 |
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