Effect of high dietary copper on the expression of hypothalamic appetite regulators in weanling pigs
D. Zhu 1,   B. Yu 1,   C. Ju 1,   S. Mei 1,   D. Chen 1  
More details
Hide details
Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-resistant Nutrition, Ministry of Education, Ya’an, Sichuan, 625014, P.R. China
D. Chen   

Institute of Animal Nutrition, Sichuan Agricultural University, Key Laboratory of Animal Disease-resistant Nutrition, Ministry of Education, Ya’an, Sichuan, 625014, P.R. China
Publication date: 2011-03-12
J. Anim. Feed Sci. 2011;20(1):60–70
The current study evaluated appetite-related gene expression of neuropeptide Y (NPY), orexin, type 2 orexin receptor (OrexinR2), proopiomelanocortin (POMC), melanocortin-4 receptor (MC4R), AMP-activated protein kinase α2 subunit (AMPKα2) and long-form leptin receptor (LeptinRb) in hypothalamus in response to copper (Cu) supplementation. One hundred crossbred pigs were assigned to four groups of 25 pigs, each comprising five replicates of 5 animals. Groups were then randomly assigned to treatments consisted of 1. control (10 mg/kg CuSO4), 2. 100 mg/kg CuSO4, 3. 175 mg/kg CuSO4, 4. 250 mg/kg CuSO4. On d 21 of the experiment 5 pigs from each group were slaughtered and the hypothalami were collected for determination of appetite-regulating genes mRNA expression level. The results showed that average daily feed intake and average daily gain were higher (P<0.05) in 250 and 175, 250 mg/kg Cu supplemented groups, respectively, than in the 10 mg/kg group. Feed:gain ratio was lower in pigs fed the diets with 250 mg/kg Cu (P<0.05) than in the 10 mg/kg group. Furthermore, the abundances of NPY mRNA in hypothalamus were higher in 250 mg/kg Cu supplemented groups (P<0.05), whereas the abundances of POMC and LeptinRb mRNA were significantly reduced (P<0.05) in 170, 250 mg/kg and 100, 175, 250 mg/kg Cu supplemented groups, respectively. No difference was found for AMPKα2, MC4R, orexin, OrexinR2 mRNA expression (P>0.05). These data suggest that down-regulation of LeptinRb mRNA expression might contribute to the stimulation of feeding of high dietary Cu supplementation via regulation of NPY and POMC mRNA expression.
Effects of graded levels of cupric citrate on growth performance, antioxidant status, serum lipid metabolites and immunity, and tissue residues of trace elements in weaned pigs
Chu Cai Peng, Jia You Yan, Bin Dong, Lin Zhu, Yao Yao Tian, Li Min Gong
Asian-Australasian Journal of Animal Sciences
Prenatal Treatment of Mosaic Mice (Atp7a mo-ms) Mouse Model for Menkes Disease, with Copper Combined by Dimethyldithiocarbamate (DMDTC)
Małgorzata Lenartowicz, Wojciech Krzeptowski, Paweł Koteja, Katarzyna Chrząścik, Lisbeth Birk Møller, Efthimios M. C. Skoulakis
Revision of the currently authorised maximum copper content in complete feed
EFSA Journal
Copper nanoparticles as an alternative feed additive in poultry diet: a review
Abdullah Scott, Krishna Prasad Vadalasetty, André Chwalibog, Ewa Sawosz
Nanotechnology Reviews
Multitrial analysis of the effects of copper level and source on performance in nursery pigs1
Y. L. Ma, G. I. Zanton, J. Zhao, K. Wedekind, J. Escobar, M. Vazquez-Añón
Journal of Animal Science
Effects of copper hydroxychloride and choice white grease on growth performance and blood characteristics of weanling pigs kept at normal ambient temperature or under heat stress
C.D. Espinosa, R.S. Fry, J.L. Usry, H.H. Stein
Animal Feed Science and Technology
Compensation effects of coated cysteamine on meat quality, amino acid composition, fatty acid composition, mineral content in dorsal muscle and serum biochemical indices in finishing pigs offered reduced trace minerals diet
Miaomiao Bai, Hongnan Liu, Xiaofeng Zhang, Baichuan Deng, Chengquan Tan, Jinping Deng, Pingping Bing, Yulong Yin
Science China Life Sciences
Effect of dietary copper sources on performance, gastric ghrelin-RNA expression, and growth hormone concentrations in serum in piglets
Ricardo Gonzalez-Esquerra, Raquel Araujo, Douglas Haese, Joao Kill, Anderson Cunha, Paulo Monzani, Cesar Lima
Journal of Animal Science
Optimal dietary copper requirements and relative bioavailability for weanling pigs fed either copper proteinate or tribasic copper chloride
Gang Lin, Yang Guo, Bing Liu, Ruiguo Wang, Xiaoou Su, Dongyou Yu, Pingli He
Journal of Animal Science and Biotechnology