ORIGINAL PAPER
A note on frequency of A1 and A2 variants of bovine beta-casein locus in Polish Holstein bulls
S. Kamiński 1  
,   A. Ruść 1,   A. Cieślińska 1
 
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University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, Oczapowskiego 5, 10-718 Olsztyn, Poland
CORRESPONDING AUTHOR
S. Kamiński   

University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, Oczapowskiego 5, 10-718 Olsztyn, Poland
Publication date: 2006-04-12
 
J. Anim. Feed Sci. 2006;15(2):195–198
 
KEYWORDS
ABSTRACT
Besides its nutritional value, bovine beta-casein is a source of bioactive peptides called beta-casomorphins produced during digestion of raw or processed milk. It was shown that the beta-casomorphin 7 originates only from beta-casein variants A1 or B and may be a significant risk factor in human ischemic heart disease, arteriosclerosis, type I diabetes and sudden infant death syndrome. In this study, the frequency of the A1 allele in a sample of Polish Holstein bulls commonly used in artificial insemination (A. I. bulls) was analysed and the potential for production of milk capable of releasing undesirable beta-casomorphin 7 is discussed. Among 143 A. I. bulls, three genotypes were identified (A1/A1, A2/A2, A1/A2) resulting in frequencies of 0.402 and 0.598, for A1 and A2, respectively. Although, the clinical implications of A1 milk on human health is still under discussion it may be necessary to monitor reproductive bulls and decrease the frequency of allele A1.
 
CITATIONS (8):
1.
Polymorphism of bovine beta-casein and its potential effect on human health
Stanisław Kamiński, Anna Cieślińska, Elżbieta Kostyra
Journal of Applied Genetics
 
2.
Genetic association analysis reveals significant effect of β-casein A1/A2 loci on production & reproduction traits in Frieswal crossbred cows
Adesh Kumar, Ran Vir Singh, Anuj Chauhan, K Ilayakumar, Sushil Kumar, Amit Kumar, Arvind Sonwane, Subodh Kumar, Manjit Panigrahi, Bharat Bhushan
Biological Rhythm Research
 
3.
Milk from cows of different β-casein genotypes as a source of β-casomorphin-7
Anna Cieślińska, Elżbieta Kostyra, Henryk Kostyra, Kamil Oleński, Ewa Fiedorowicz, Stanisław Kamiński
International Journal of Food Sciences and Nutrition
 
4.
Genetic Polymorphism of β-Casein Gene in Polish Red Cattle—Preliminary Study of A1 and A2 Frequency in Genetic Conservation Herd
Anna Cieślińska, Ewa Fiedorowicz, Grzegorz Zwierzchowski, Natalia Kordulewska, Beata Jarmołowska, Elżbieta Kostyra
Animals
 
5.
New high-sensitive rhAmp method for A1 allele detection in A2 milk samples
Rodrigo Giglioti, Gunta Gutmanis, Katiki Morita, Okino Hiromi, Sena de, Vercesi-Filho Eugênio
Food Chemistry
 
6.
Beta-Casein Gene Polymorphism in Serbian Holstein-Friesian Cows and Its Relationship with Milk Production Traits
Ristanic Marko, Glavinic Uros, Vejnovic Branislav, Maletic Milan, Kirovski Danijela, Teodorovic Vlado, Stanimirovic Zoran
Acta Veterinaria
 
7.
Investigation of genetic polymorphism at β-casein A1/A2 loci and association analysis with production & reproduction traits in Vrindavani crossbred cows
Adesh Kumar, Sushil Kumar, Ran Singh, Anuj Chauhan, Amit Kumar, Arvind Sonwane, Ilayakumar K, Rahul Singh
Animal Biotechnology
 
8.
Do non-bovine domestic animals produce A2 milk?: an in silico analysis
Louise Oliveira, Jackeline Alves, Marisa Bastos, Raphael Costa, Camargo de
Animal Biotechnology
 
ISSN:1230-1388