ORIGINAL PAPER
A note on frequency of A1 and A2 variants of
bovine beta-casein locus in Polish Holstein bulls
| 1 | University of Warmia and Mazury in Olsztyn, Department of Animal Genetics,
Oczapowskiego 5, 10-718 Olsztyn, Poland |
CORRESPONDING AUTHOR
S. Kamiński
University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, Oczapowskiego 5, 10-718 Olsztyn, Poland
University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, Oczapowskiego 5, 10-718 Olsztyn, Poland
Publication date: 2006-04-12
J. Anim. Feed Sci. 2006;15(2):195–198
KEYWORDS
ABSTRACT
Besides its nutritional value, bovine beta-casein is a source of bioactive peptides called beta-casomorphins produced during digestion of raw or processed milk. It was shown that the beta-casomorphin 7 originates only from beta-casein variants A1 or B and may be a significant risk factor
in human ischemic heart disease, arteriosclerosis, type I diabetes and sudden infant death syndrome.
In this study, the frequency of the A1 allele in a sample of Polish Holstein bulls commonly used in
artificial insemination (A. I. bulls) was analysed and the potential for production of milk capable
of releasing undesirable beta-casomorphin 7 is discussed. Among 143 A. I. bulls, three genotypes
were identified (A1/A1, A2/A2, A1/A2) resulting in frequencies of 0.402 and 0.598, for A1 and A2,
respectively. Although, the clinical implications of A1 milk on human health is still under discussion
it may be necessary to monitor reproductive bulls and decrease the frequency of allele A1.
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