ORIGINAL PAPER
A note on frequency of A1 and A2 variants of
bovine beta-casein locus in Polish Holstein bulls
| 1 | University of Warmia and Mazury in Olsztyn, Department of Animal Genetics,
Oczapowskiego 5, 10-718 Olsztyn, Poland |
CORRESPONDING AUTHOR
S. Kamiński
University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, Oczapowskiego 5, 10-718 Olsztyn, Poland
University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, Oczapowskiego 5, 10-718 Olsztyn, Poland
Publication date: 2006-04-12
J. Anim. Feed Sci. 2006;15(2):195–198
KEYWORDS
ABSTRACT
Besides its nutritional value, bovine beta-casein is a source of bioactive peptides called beta-casomorphins produced during digestion of raw or processed milk. It was shown that the beta-casomorphin 7 originates only from beta-casein variants A1 or B and may be a significant risk factor
in human ischemic heart disease, arteriosclerosis, type I diabetes and sudden infant death syndrome.
In this study, the frequency of the A1 allele in a sample of Polish Holstein bulls commonly used in
artificial insemination (A. I. bulls) was analysed and the potential for production of milk capable
of releasing undesirable beta-casomorphin 7 is discussed. Among 143 A. I. bulls, three genotypes
were identified (A1/A1, A2/A2, A1/A2) resulting in frequencies of 0.402 and 0.598, for A1 and A2,
respectively. Although, the clinical implications of A1 milk on human health is still under discussion
it may be necessary to monitor reproductive bulls and decrease the frequency of allele A1.
CITATIONS (8):
1.
Polymorphism of bovine beta-casein and its potential effect on human health
Stanisław Kamiński, Anna Cieślińska, Elżbieta Kostyra
Journal of Applied Genetics
Stanisław Kamiński, Anna Cieślińska, Elżbieta Kostyra
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2.
Genetic association analysis reveals significant effect of β-casein A1/A2 loci on production & reproduction traits in Frieswal crossbred cows
Adesh Kumar, Ran Vir Singh, Anuj Chauhan, K Ilayakumar, Sushil Kumar, Amit Kumar, Arvind Sonwane, Subodh Kumar, Manjit Panigrahi, Bharat Bhushan
Biological Rhythm Research
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Anna Cieślińska, Elżbieta Kostyra, Henryk Kostyra, Kamil Oleński, Ewa Fiedorowicz, Stanisław Kamiński
International Journal of Food Sciences and Nutrition
Anna Cieślińska, Elżbieta Kostyra, Henryk Kostyra, Kamil Oleński, Ewa Fiedorowicz, Stanisław Kamiński
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Genetic Polymorphism of β-Casein Gene in Polish Red Cattle—Preliminary Study of A1 and A2 Frequency in Genetic Conservation Herd
Anna Cieślińska, Ewa Fiedorowicz, Grzegorz Zwierzchowski, Natalia Kordulewska, Beata Jarmołowska, Elżbieta Kostyra
Animals
Anna Cieślińska, Ewa Fiedorowicz, Grzegorz Zwierzchowski, Natalia Kordulewska, Beata Jarmołowska, Elżbieta Kostyra
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New high-sensitive rhAmp method for A1 allele detection in A2 milk samples
Rodrigo Giglioti, Gunta Gutmanis, Katiki Morita, Okino Hiromi, Sena de, Vercesi-Filho Eugênio
Food Chemistry
Rodrigo Giglioti, Gunta Gutmanis, Katiki Morita, Okino Hiromi, Sena de, Vercesi-Filho Eugênio
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Adesh Kumar, Sushil Kumar, Ran Singh, Anuj Chauhan, Amit Kumar, Arvind Sonwane, Ilayakumar K, Rahul Singh
Animal Biotechnology
Adesh Kumar, Sushil Kumar, Ran Singh, Anuj Chauhan, Amit Kumar, Arvind Sonwane, Ilayakumar K, Rahul Singh
Animal Biotechnology
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Do non-bovine domestic animals produce A2 milk?: an in silico analysis
Louise Oliveira, Jackeline Alves, Marisa Bastos, Raphael Costa, Camargo de
Animal Biotechnology
Louise Oliveira, Jackeline Alves, Marisa Bastos, Raphael Costa, Camargo de
Animal Biotechnology
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