1.054
IF5
1.150
IF
Q3
JCR
1.7
CiteScore
0.396
SJR
Q2
SJR
40
MNiSW
148.75
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

A note on frequency of A1 and A2 variants of bovine beta-casein locus in Polish Holstein bulls

S. Kamiński 1  ,  
A. Ruść 1,  
 
1
University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, Oczapowskiego 5, 10-718 Olsztyn, Poland
J. Anim. Feed Sci. 2006;15(2):195–198
Publication date: 2006-04-12
KEYWORDS
ABSTRACT
Besides its nutritional value, bovine beta-casein is a source of bioactive peptides called beta-casomorphins produced during digestion of raw or processed milk. It was shown that the beta-casomorphin 7 originates only from beta-casein variants A1 or B and may be a significant risk factor in human ischemic heart disease, arteriosclerosis, type I diabetes and sudden infant death syndrome. In this study, the frequency of the A1 allele in a sample of Polish Holstein bulls commonly used in artificial insemination (A. I. bulls) was analysed and the potential for production of milk capable of releasing undesirable beta-casomorphin 7 is discussed. Among 143 A. I. bulls, three genotypes were identified (A1/A1, A2/A2, A1/A2) resulting in frequencies of 0.402 and 0.598, for A1 and A2, respectively. Although, the clinical implications of A1 milk on human health is still under discussion it may be necessary to monitor reproductive bulls and decrease the frequency of allele A1.
CORRESPONDING AUTHOR
S. Kamiński   
University of Warmia and Mazury in Olsztyn, Department of Animal Genetics, Oczapowskiego 5, 10-718 Olsztyn, Poland
 
CITATIONS (5):
1. Polymorphism of bovine beta-casein and its potential effect on human health
Stanisław Kamiński, Anna Cieślińska, Elżbieta Kostyra
Journal of Applied Genetics
2. Genetic association analysis reveals significant effect of β-casein A1/A2 loci on production & reproduction traits in Frieswal crossbred cows
Adesh Kumar, Ran Vir Singh, Anuj Chauhan, K Ilayakumar, Sushil Kumar, Amit Kumar, Arvind Sonwane, Subodh Kumar, Manjit Panigrahi, Bharat Bhushan
Biological Rhythm Research
3. Milk from cows of different β-casein genotypes as a source of β-casomorphin-7
Anna Cieślińska, Elżbieta Kostyra, Henryk Kostyra, Kamil Oleński, Ewa Fiedorowicz, Stanisław Kamiński
International Journal of Food Sciences and Nutrition
4. Genetic Polymorphism of β-Casein Gene in Polish Red Cattle—Preliminary Study of A1 and A2 Frequency in Genetic Conservation Herd
Anna Cieślińska, Ewa Fiedorowicz, Grzegorz Zwierzchowski, Natalia Kordulewska, Beata Jarmołowska, Elżbieta Kostyra
Animals
5. New high-sensitive rhAmp method for A1 allele detection in A2 milk samples
Rodrigo Giglioti, Gunta Gutmanis, Katiki Morita, Okino Hiromi, Sena de, Vercesi-Filho Eugênio
Food Chemistry
ISSN:1230-1388