ORIGINAL PAPER
Uricemia in juvenile pigs model: effect of nephrectomy and potassium oxonate
| 1 | Vasyl Stefanyk Precarpathian National University, 76018, Ivano-Frankivs’k, Ukraine |
| 2 | Lund University, Department of Biology, 223 62 Lund, Sweden |
| 3 | Allena Pharmaceuticals, Newton, MA 02462, USA |
| 4 | The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland |
| 5 | Clinical Research Centre of Bonding/Welding Surgery and New Surgical Technologies at Kyiv Municipal Hospital Clinic No.1, 02091, Kyiv, Ukraine |
| 6 | National Research Institute of Animal Production, Department of Animal Nutrition and Feed Sciences, 32-083 Balice, Poland |
| 7 | Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, Department of Enzymes Chemistry and Biochemistry, 01030, Kyiv, Ukraine |
| 8 | R&D Anara AB, 231 32 Trelleborg, Sweden |
CORRESPONDING AUTHOR
Publication date: 2019-09-23
J. Anim. Feed Sci. 2019;28(3):254–262
KEYWORDS
TOPICS
ABSTRACT
Uric acid is the end product of dietary and endogenous purine
metabolism in humans and higher primates. In all lower mammalian species it is
converted to allantoin by liver uricase. The aim of this study was to investigate
the uric acid turnover in pig model after nephrectomy surgery, fructose-enriched
diet and potassium oxonate application. The first experiment was performed
using 4 intact control pigs and 8 nephrectomized (5/6 nephrectomy) pigs. Both
groups were fed high-fat diet enriched with 20% of fructose for 3 weeks. During
the second experiment, as another approach to induce hyperuricemia, potassium
oxonate solution (POx) was administered intravenously to 4 healthy pigs,
once or twice per day. In the third preliminary experiment one healthy and two
nephrectomized (9/10 nephrectomy) pigs were infused with POx to induce hyperuricemia.
Results showed that 5/6 nephrectomy did not affect plasma uric
acid concentration for 25 days following surgery. The consumption of the high-fat
diet enriched with 20% of fructose did not result in the rise of plasma uric
acid, either in healthy or nephrectomized pigs. Administration of POx solution to
healthy and 9/10 nephrectomized pigs resulted in significantly increased plasma
uric acid concentrations for 18 h and 24 h, respectively, following a single POx
infusion. The present study expands today available data on uric acid metabolism
in pigs as a model for exploring uricemia in human with kidney dysfunction.
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