ORIGINAL PAPER
Uricemia in juvenile pigs model: effect of nephrectomy and potassium oxonate
| 1 | Vasyl Stefanyk Precarpathian National University, 76018, Ivano-Frankivs’k, Ukraine |
| 2 | Lund University, Department of Biology, 223 62 Lund, Sweden |
| 3 | Allena Pharmaceuticals, Newton, MA 02462, USA |
| 4 | The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland |
| 5 | Clinical Research Centre of Bonding/Welding Surgery and New Surgical Technologies at Kyiv Municipal Hospital Clinic No.1, 02091, Kyiv, Ukraine |
| 6 | National Research Institute of Animal Production, Department of Animal Nutrition and Feed Sciences, 32-083 Balice, Poland |
| 7 | Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, Department of Enzymes Chemistry and Biochemistry, 01030, Kyiv, Ukraine |
| 8 | R&D Anara AB, 231 32 Trelleborg, Sweden |
CORRESPONDING AUTHOR
Publication date: 2019-09-23
J. Anim. Feed Sci. 2019;28(3):254–262
KEYWORDS
TOPICS
ABSTRACT
Uric acid is the end product of dietary and endogenous purine
metabolism in humans and higher primates. In all lower mammalian species it is
converted to allantoin by liver uricase. The aim of this study was to investigate
the uric acid turnover in pig model after nephrectomy surgery, fructose-enriched
diet and potassium oxonate application. The first experiment was performed
using 4 intact control pigs and 8 nephrectomized (5/6 nephrectomy) pigs. Both
groups were fed high-fat diet enriched with 20% of fructose for 3 weeks. During
the second experiment, as another approach to induce hyperuricemia, potassium
oxonate solution (POx) was administered intravenously to 4 healthy pigs,
once or twice per day. In the third preliminary experiment one healthy and two
nephrectomized (9/10 nephrectomy) pigs were infused with POx to induce hyperuricemia.
Results showed that 5/6 nephrectomy did not affect plasma uric
acid concentration for 25 days following surgery. The consumption of the high-fat
diet enriched with 20% of fructose did not result in the rise of plasma uric
acid, either in healthy or nephrectomized pigs. Administration of POx solution to
healthy and 9/10 nephrectomized pigs resulted in significantly increased plasma
uric acid concentrations for 18 h and 24 h, respectively, following a single POx
infusion. The present study expands today available data on uric acid metabolism
in pigs as a model for exploring uricemia in human with kidney dysfunction.
REFERENCES (35)
1.
Bogdan V.F., Gupalo Yu. M., Gichka S.G., Furmanov Ju.O., Lebedev O.V., Nichitailo M.Ju., Petrenko O.F., Podpryatov S.E., Podpriatov S.S., 2009. Development of high-frequency surgical electrofusion technology, performed with the use of automation systems. In: B.E. Paton, O.N. Ivanova (Editors). Tissue-preserving high-frequency electric welding surgery (in Russian). Naukova dumka. Kiev (Ukraine), pp. 68–99
2.
de Oliveira E.P., Burini R.C., 2012. High plasma uric acid concentration: causes and consequences. Diabetol. Metab. Syndr. 4, 12, https://doi.org/10.1186/1758-5....
3.
Fathallah-Shaykh S.A., Cramer M.T., 2014. Uric acid and the kidney. Pediatr. Nephrol. 29, 999–1008, https://doi.org/10.1007/s00467....
4.
Fridovich I., 1965. The competitive inhibition of uricase by oxonate and by related derivatives of s-triazines. J. Biol. Chem. 240, 2491–2494.
5.
Gersch M.S., Mu W., Cirillo P., Reungjui S., Zhang L., Roncal C., Sautin Y.Y., Johnson R.J., Nakagawa T., 2007. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am. J. Physiol. Renal. Physiol. 293, F1256–F1261, https://doi.org/10.1152/ajpren....
6.
Gupta A., Biyani M., Gupta M., Saltel M.E., 2011. Hypercreatinemia: think beyond acute kidney injury. Can. J. Urol. 18, 6066–6068.
7.
Hatch M., Vaziri N.D., 1994. Enhanced enteric excretion of urate in rats with chronic renal failure. Clin. Sci. 86, 511–516, https://doi.org/10.1042/cs0860....
8.
Hatfield P.J., Simmonds H.A., Cameron J.S., Jones A.S., Cadenhead A., 1974. Effects of allopurinol and oxonic acid on pyrimidine metabolism in the pig. In: O. Sperling, A. De Vries, J.B. Wyngaarden (Editors). Purine Metabolism in Man. Plenum, New York (USA), pp. 637–638, https://doi.org/10.1007/978-1-....
9.
Heyman S.N., Rosenberger C., Rosen S., 2011. Acute kidney injury: lessons from experimental models. In: G.A. Herrera (Editor). Experimental Models for Renal Diseases. Pathogenesis and Diagnosis. Karger Publishers. Basel (Switzerland), pp. 286–296, https://doi.org/10.1159/000313....
10.
Hu Q.-H., Zhu J.-X., Ji J., Wei L.-L., Miao M.-X., Ji H., 2013. Fructus gardenia extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3. Molecules 18, 8976–8993, https://doi.org/10.3390/molecu....
11.
Ichida K., Matsuo H., Takada T. et al., 2012. Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat. Commun. 3, 764, https://doi.org/10.1038/ncomms....
12.
Jalal D.I., Chonchol M., Chen W., Targher G., 2013. Uric acid as a target of therapy in CKD. Am. J. Kidney Dis. 61, 134–146, https://doi.org/10.1053/j.ajkd....
13.
Johnson R.J., Gaucher E.A., Sautin Y.Y., Henderson G.N., Angerhofer A.J., Benner S.A., 2008. The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. Med. Hypotheses 71, 22–31, https://doi.org/10.1016/j.mehy....
14.
Johnson R.J., Nakagawa T., Jalal D., Sánchez-Lozada L.G., Kang D.-H., Ritz E., 2013a. Uric acid and chronic kidney disease: which is chasing which? Nephrol. Dial. Transplant. 28, 2221–2228, https://doi.org/10.1093/ndt/gf....
15.
Johnson R.J., Nakagawa T., Sanchez-Lozada L.G., Shafiu M., Sundaram S., Le M., Ishimoto T., Sautin Y.Y., Lanaspa M.A., 2013b. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 62, 3307–3315, https://doi.org/10.2337/db12-1....
16.
Kang D.-H., Nakagawa T., 2005. Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease. Semin. Nephrol. 25, 43–49, https://doi.org/10.1016/j.semn....
17.
Kretowicz M., Johnson R.J., Ishimoto T., Nakagawa T., Manitius J., 2011. The impact of fructose on renal function and blood pressure. Int. J. Nephrol. 2011, 315879, https://doi.org/10.4061/2011/3....
18.
Lee S.J., Terkeltaub R.A., Kavanaugh A., 2006. Recent developments in diet and gout. Curr. Opin. Rheumatol. 18, 193–198, https://doi.org/10.1097/01.bor....
19.
Lee I.R., Yang L., Sebetso G., Allen R., Doan T.H.N., Blundell R., Lui E.Y.L., Morrow C.A., Fraser J.A., 2013. Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans. PLoS ONE 8, e64292, https://doi.org/10.1371/journa....
20.
Levey A.S., Coresh J., 2012. Chronic kidney disease. Lancet 379, 165–180, https://doi.org/10.1016/S0140-....
21.
Malagrino P.A., Venturini G., Yogi P.S. et al., 2014. Catheter-based induction of renal ischemia/reperfusion in swine: description of an experimental model. Physiol. Rep. 2, e12150, https://doi.org/10.14814/phy2.....
22.
Mandal A.K., Mount D.B., 2015. The molecular physiology of uric acid homeostasis. Annu. Rev. Physiol. 77, 323–345, https://doi.org/10.1146/annure....
23.
Murota I., Tamai T., Baba T., Sato N., Park E.Y., Nakamura Y., Sato K., 2012. Moderation of oxonate-induced hyperuricemia in rats via the ingestion of an ethanol-soluble fraction of a shark cartilage proteolytic digest. J. Funct. Foods 4, 459–464, https://doi.org/10.1016/j.jff.....
24.
Podpryatov S.E., Shved O.E., Gupalo Yu.M., Podpriatov S.S., Lebedev A.V., Gichka S.G., Dubko A.G., Trunov A.E., Bernadsky V.V., Zelnichenko A.T., 2007. Artery crossing using automatic welding (in Ukrainian). Klin. Khir. 5, 55–57.
25.
Rengman S., Fedkiv O., Botermans J., Svendsen J.R., Weström B., Pierzynowski S., 2009. An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency. Clin. Nutr. 28, 325–330, https://doi.org/10.1016/j.clnu....
26.
Roch-Ramel F., Peters G., 1978. Urinary excretion of uric acid in nonhuman mammalian species. In: W.N. Kelley, I.M. Weiner (Editors). Uric Acid. Handbook of Experimental Pharmacology (Continuation of Handbuch der experimentellen Pharmakologie), vol 51. Springer, Berlin (Germany), pp. 211–255, https://doi.org/10.1007/978-3-....
27.
Simmonds H.A., Hatfield P.J., Cameron J.S., Cadenhead A., 1976. Uric acid excretion by the pig kidney. Am. J. Physiol. 230, 1654–1661, https://doi.org/10.1152/ajpleg....
28.
Stavric B., Johnson W.J., Clayman S., Gadd R.E.A., Chartrand A., 1976. Effect of fructose administration on serum urate levels in the uricase inhibited rat. Experientia 32, 373–374, https://doi.org/10.1007/BF0194....
29.
Stavric B., Johnson W.J., Grice H.C., 1969. Uric acid nephropathy: an experimental model. Proc. Soc. Exp. Biol. Med. 130, 512–516, https://doi.org/10.3181/003797....
30.
Stavric B., Nera E.A., 1978. Use of the uricase-inhibited rat as an animal model in toxicology. Clin. Toxicol. 13, 47–74, https://doi.org/10.3109/155636....
31.
Swindle M.M., Makin A., Herron A.J., Clubb F.J., Frazier K.S., 2012. Swine as models in biomedical research and toxicology testing. Vet. Pathol. 49, 344–356, https://doi.org/10.1177/030098....
32.
Szczurek P., Mosiichuk N., Woliński J., Yatsenko T., Grujic D., Lozinska L., Pieszka M., Święch E., Pierzynowski S.G., Goncharova K., 2017. Oral uricase eliminates blood uric acid in the hyperuricemic pig model. PLoS ONE 12, e0179195, https://doi.org/10.1371/journa....
33.
Terkeltaub R., 2010. Update on gout: new therapeutic strategies and options. Nat. Rev. Rheumatol. 6, 30–38, https://doi.org/10.1038/nrrheu....
34.
Vaziri N.D., 2006. Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences. Am. J. Physiol. Renal. Physiol. 290, F262–F272, https://doi.org/10.1152/ajpren....
35.
Yonetani Y., Ishii M., Iwaki K., 1980. Hyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats. Jpn. J. Pharmacol. 30, 829–840, https://doi.org/10.1254/jjp.30....
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