0.906
IF5
0.875
IF
Q3
JCR
1.0
CiteScore
0.374
SJR
Q2
SJR
20
MNiSW
165.24
ICV
Submit your paper
Instructions for Authors Archive
3/2019 vol. 28
PREVIOUS NEXT
ORIGINAL PAPER
 
CC-BY 4.0
 
 

Uricemia in juvenile pigs model: effect of nephrectomy and potassium oxonate

N. Mosiichuk 1, 2  ,  
D. Grujic 3,  
J. Woliński 4,  
S.E. Podpryatov 5,  
S.S. Podpriatov 5,  
P. Szczurek 6,  
T. Yatsenko 7,  
H. Shmihel 1,  
O. Drahanchuk 4,  
S.G. Pierzynowski 2, 8,  
K. Goncharova Pierzynowska 2, 8  
 
1
Vasyl Stefanyk Precarpathian National University, 76018, Ivano-Frankivs’k, Ukraine
2
Lund University, Department of Biology, 223 62 Lund, Sweden
3
Allena Pharmaceuticals, Newton, MA 02462, USA
4
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
5
Clinical Research Centre of Bonding/Welding Surgery and New Surgical Technologies at Kyiv Municipal Hospital Clinic No.1, 02091, Kyiv, Ukraine
6
National Research Institute of Animal Production, Department of Animal Nutrition and Feed Sciences, 32-083 Balice, Poland
7
Palladin Institute of Biochemistry of National Academy of Sciences of Ukraine, Department of Enzymes Chemistry and Biochemistry, 01030, Kyiv, Ukraine
8
R&D Anara AB, 231 32 Trelleborg, Sweden
J. Anim. Feed Sci. 2019;28(3):254–262
Publish date: 2019-09-23
DOI: https://doi.org/10.22358/jafs/110436/2019
Stats Article (PDF)
Get citation
References (35)
 
KEYWORDS
creatinine, fructose, hyperuricemia, pigs, potassium oxonate, uric acid
TOPICS
pigs
ABSTRACT
Uric acid is the end product of dietary and endogenous purine metabolism in humans and higher primates. In all lower mammalian species it is converted to allantoin by liver uricase. The aim of this study was to investigate the uric acid turnover in pig model after nephrectomy surgery, fructose-enriched diet and potassium oxonate application. The first experiment was performed using 4 intact control pigs and 8 nephrectomized (5/6 nephrectomy) pigs. Both groups were fed high-fat diet enriched with 20% of fructose for 3 weeks. During the second experiment, as another approach to induce hyperuricemia, potassium oxonate solution (POx) was administered intravenously to 4 healthy pigs, once or twice per day. In the third preliminary experiment one healthy and two nephrectomized (9/10 nephrectomy) pigs were infused with POx to induce hyperuricemia. Results showed that 5/6 nephrectomy did not affect plasma uric acid concentration for 25 days following surgery. The consumption of the high-fat diet enriched with 20% of fructose did not result in the rise of plasma uric acid, either in healthy or nephrectomized pigs. Administration of POx solution to healthy and 9/10 nephrectomized pigs resulted in significantly increased plasma uric acid concentrations for 18 h and 24 h, respectively, following a single POx infusion. The present study expands today available data on uric acid metabolism in pigs as a model for exploring uricemia in human with kidney dysfunction.
CORRESPONDING AUTHOR
K. Goncharova Pierzynowska   
Department of Biology, Lund University, Sweden
 
REFERENCES (35):
1. Bogdan V.F., Gupalo Yu. M., Gichka S.G., Furmanov Ju.O., Lebedev O.V., Nichitailo M.Ju., Petrenko O.F., Podpryatov S.E., Podpriatov S.S., 2009. Development of high-frequency surgical electrofusion technology, performed with the use of automation systems. In: B.E. Paton, O.N. Ivanova (Editors). Tissue-preserving high-frequency electric welding surgery (in Russian). Naukova dumka. Kiev (Ukraine), pp. 68–99
2. de Oliveira E.P., Burini R.C., 2012. High plasma uric acid concentration: causes and consequences. Diabetol. Metab. Syndr. 4, 12, https://doi.org/10.1186/1758-5....
3. Fathallah-Shaykh S.A., Cramer M.T., 2014. Uric acid and the kidney. Pediatr. Nephrol. 29, 999–1008, https://doi.org/10.1007/s00467....
4. Fridovich I., 1965. The competitive inhibition of uricase by oxonate and by related derivatives of s-triazines. J. Biol. Chem. 240, 2491–2494.
5. Gersch M.S., Mu W., Cirillo P., Reungjui S., Zhang L., Roncal C., Sautin Y.Y., Johnson R.J., Nakagawa T., 2007. Fructose, but not dextrose, accelerates the progression of chronic kidney disease. Am. J. Physiol. Renal. Physiol. 293, F1256–F1261, https://doi.org/10.1152/ajpren....
6. Gupta A., Biyani M., Gupta M., Saltel M.E., 2011. Hypercreatinemia: think beyond acute kidney injury. Can. J. Urol. 18, 6066–6068.
7. Hatch M., Vaziri N.D., 1994. Enhanced enteric excretion of urate in rats with chronic renal failure. Clin. Sci. 86, 511–516, https://doi.org/10.1042/cs0860....
8. Hatfield P.J., Simmonds H.A., Cameron J.S., Jones A.S., Cadenhead A., 1974. Effects of allopurinol and oxonic acid on pyrimidine metabolism in the pig. In: O. Sperling, A. De Vries, J.B. Wyngaarden (Editors). Purine Metabolism in Man. Plenum, New York (USA), pp. 637–638, https://doi.org/10.1007/978-1-....
9. Heyman S.N., Rosenberger C., Rosen S., 2011. Acute kidney injury: lessons from experimental models. In: G.A. Herrera (Editor). Experimental Models for Renal Diseases. Pathogenesis and Diagnosis. Karger Publishers. Basel (Switzerland), pp. 286–296, https://doi.org/10.1159/000313....
10. Hu Q.-H., Zhu J.-X., Ji J., Wei L.-L., Miao M.-X., Ji H., 2013. Fructus gardenia extract ameliorates oxonate-induced hyperuricemia with renal dysfunction in mice by regulating organic ion transporters and mOIT3. Molecules 18, 8976–8993, https://doi.org/10.3390/molecu....
11. Ichida K., Matsuo H., Takada T. et al., 2012. Decreased extra-renal urate excretion is a common cause of hyperuricemia. Nat. Commun. 3, 764, https://doi.org/10.1038/ncomms....
12. Jalal D.I., Chonchol M., Chen W., Targher G., 2013. Uric acid as a target of therapy in CKD. Am. J. Kidney Dis. 61, 134–146, https://doi.org/10.1053/j.ajkd....
13. Johnson R.J., Gaucher E.A., Sautin Y.Y., Henderson G.N., Angerhofer A.J., Benner S.A., 2008. The planetary biology of ascorbate and uric acid and their relationship with the epidemic of obesity and cardiovascular disease. Med. Hypotheses 71, 22–31, https://doi.org/10.1016/j.mehy....
14. Johnson R.J., Nakagawa T., Jalal D., Sánchez-Lozada L.G., Kang D.-H., Ritz E., 2013a. Uric acid and chronic kidney disease: which is chasing which? Nephrol. Dial. Transplant. 28, 2221–2228, https://doi.org/10.1093/ndt/gf....
15. Johnson R.J., Nakagawa T., Sanchez-Lozada L.G., Shafiu M., Sundaram S., Le M., Ishimoto T., Sautin Y.Y., Lanaspa M.A., 2013b. Sugar, uric acid, and the etiology of diabetes and obesity. Diabetes 62, 3307–3315, https://doi.org/10.2337/db12-1....
16. Kang D.-H., Nakagawa T., 2005. Uric acid and chronic renal disease: possible implication of hyperuricemia on progression of renal disease. Semin. Nephrol. 25, 43–49, https://doi.org/10.1016/j.semn....
17. Kretowicz M., Johnson R.J., Ishimoto T., Nakagawa T., Manitius J., 2011. The impact of fructose on renal function and blood pressure. Int. J. Nephrol. 2011, 315879, https://doi.org/10.4061/2011/3....
18. Lee S.J., Terkeltaub R.A., Kavanaugh A., 2006. Recent developments in diet and gout. Curr. Opin. Rheumatol. 18, 193–198, https://doi.org/10.1097/01.bor....
19. Lee I.R., Yang L., Sebetso G., Allen R., Doan T.H.N., Blundell R., Lui E.Y.L., Morrow C.A., Fraser J.A., 2013. Characterization of the complete uric acid degradation pathway in the fungal pathogen Cryptococcus neoformans. PLoS ONE 8, e64292, https://doi.org/10.1371/journa....
20. Levey A.S., Coresh J., 2012. Chronic kidney disease. Lancet 379, 165–180, https://doi.org/10.1016/S0140-....
21. Malagrino P.A., Venturini G., Yogi P.S. et al., 2014. Catheter-based induction of renal ischemia/reperfusion in swine: description of an experimental model. Physiol. Rep. 2, e12150, https://doi.org/10.14814/phy2.....
22. Mandal A.K., Mount D.B., 2015. The molecular physiology of uric acid homeostasis. Annu. Rev. Physiol. 77, 323–345, https://doi.org/10.1146/annure....
23. Murota I., Tamai T., Baba T., Sato N., Park E.Y., Nakamura Y., Sato K., 2012. Moderation of oxonate-induced hyperuricemia in rats via the ingestion of an ethanol-soluble fraction of a shark cartilage proteolytic digest. J. Funct. Foods 4, 459–464, https://doi.org/10.1016/j.jff.....
24. Podpryatov S.E., Shved O.E., Gupalo Yu.M., Podpriatov S.S., Lebedev A.V., Gichka S.G., Dubko A.G., Trunov A.E., Bernadsky V.V., Zelnichenko A.T., 2007. Artery crossing using automatic welding (in Ukrainian). Klin. Khir. 5, 55–57.
25. Rengman S., Fedkiv O., Botermans J., Svendsen J.R., Weström B., Pierzynowski S., 2009. An elemental diet fed, enteral or parenteral, does not support growth in young pigs with exocrine pancreatic insufficiency. Clin. Nutr. 28, 325–330, https://doi.org/10.1016/j.clnu....
26. Roch-Ramel F., Peters G., 1978. Urinary excretion of uric acid in nonhuman mammalian species. In: W.N. Kelley, I.M. Weiner (Editors). Uric Acid. Handbook of Experimental Pharmacology (Continuation of Handbuch der experimentellen Pharmakologie), vol 51. Springer, Berlin (Germany), pp. 211–255, https://doi.org/10.1007/978-3-....
27. Simmonds H.A., Hatfield P.J., Cameron J.S., Cadenhead A., 1976. Uric acid excretion by the pig kidney. Am. J. Physiol. 230, 1654–1661, https://doi.org/10.1152/ajpleg....
28. Stavric B., Johnson W.J., Clayman S., Gadd R.E.A., Chartrand A., 1976. Effect of fructose administration on serum urate levels in the uricase inhibited rat. Experientia 32, 373–374, https://doi.org/10.1007/BF0194....
29. Stavric B., Johnson W.J., Grice H.C., 1969. Uric acid nephropathy: an experimental model. Proc. Soc. Exp. Biol. Med. 130, 512–516, https://doi.org/10.3181/003797....
30. Stavric B., Nera E.A., 1978. Use of the uricase-inhibited rat as an animal model in toxicology. Clin. Toxicol. 13, 47–74, https://doi.org/10.3109/155636....
31. Swindle M.M., Makin A., Herron A.J., Clubb F.J., Frazier K.S., 2012. Swine as models in biomedical research and toxicology testing. Vet. Pathol. 49, 344–356, https://doi.org/10.1177/030098....
32. Szczurek P., Mosiichuk N., Woliński J., Yatsenko T., Grujic D., Lozinska L., Pieszka M., Święch E., Pierzynowski S.G., Goncharova K., 2017. Oral uricase eliminates blood uric acid in the hyperuricemic pig model. PLoS ONE 12, e0179195, https://doi.org/10.1371/journa....
33. Terkeltaub R., 2010. Update on gout: new therapeutic strategies and options. Nat. Rev. Rheumatol. 6, 30–38, https://doi.org/10.1038/nrrheu....
34. Vaziri N.D., 2006. Dyslipidemia of chronic renal failure: the nature, mechanisms, and potential consequences. Am. J. Physiol. Renal. Physiol. 290, F262–F272, https://doi.org/10.1152/ajpren....
35. Yonetani Y., Ishii M., Iwaki K., 1980. Hyperuricemia induced by some antihypertensives and uricosuric drugs in oxonate-treated rats. Jpn. J. Pharmacol. 30, 829–840, https://doi.org/10.1254/jjp.30....
Send by email
Copy url
Share
 
 
Related articles
An analysis of MYH7 single nucleotide polymorphism (g.7:75667956G>A) in relation to growth and carcass traits in pigs
Proteome changes in ileal mucosa of young pigs resulting from different levels of native chicory inulin in the diet
The influence of dietary raw and extruded field peas (Pisum sativum L.) on nutrients digestibility and performance of weaned and fattening pigs
The expression profile of AQP1, AQP5 and AQP9 in granulosa and theca cells of porcine ovarian follicles during oestrous cycle and early pregnancy
Indexes
 
Keywords index
Topics index
Authors index
ISSN:1230-1388
Assigning DOI numbers, introducing articles from supplements and recent publications to POL-index database, maintaining anti-plagiarism detection, electronic system to proceed manuscripts and webpage of the Journal with interactive pdf files, and language correction of manuscripts published in Journal of Animal and Feed Sciences are financed in the years 2018–2019 by the Ministry of Science and Higher Education from the funds for science popularization activities, Agreement No. 631/P-DUN/2018.
Copyright © 2006-2019 Bentus All rights reserved.