1.054
IF5
1.150
IF
Q3
JCR
1.7
CiteScore
0.396
SJR
Q2
SJR
40
MNiSW
148.75
ICV
REVIEW PAPER
 
CC-BY 4.0
 
 

Prolactin and the physiological regulation of its secretion. A review

M. Ciechanowska 1  ,  
T. Misztal 2,  
 
1
The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Department of Pharmacology and Toxicology, Kozielska 4, 01-163 Warsaw, Poland
2
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
J. Anim. Feed Sci. 2013;22(2):79–89
Publication date: 2013-06-07
KEYWORDS
ABSTRACT
This review briefly summarizes recent findings on lactotrophs in the pituitary gland and extrapituitary tissues as a no homologous group cell types of different embryonic origin, morphology and biological function. They display a remarkable adaptation to altered physiological condition. Their functions are derived from structural polymorphism, local synthesis, divergent intracellular signaling pathways and target genes. Most of them are heterogenous with respect to basal hormone release, electrical activity and responsiveness to stimulatory/inhibitory factors, depending upon gender and physiological state of animal. The circulating prolactin (PRL) produced by many types of lactotrophs can act in edocrine/paracrine/autocrine manner, respectively as a hormone, growth factor, neurotransmitter or immunoregulator. At the cellular level PRL exerts mitogenic, morphogenic and secretory activity. Numerous factors of the central and peripheral origin are involved in the mechanism regulating PRL secretion, causing an increase or decrease of the hormone concentration in the circulation. The certain feedback mechanism keep the pituitary lactotrophs to be not overactive.
CORRESPONDING AUTHOR
M. Ciechanowska   
The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Department of Pharmacology and Toxicology, Kozielska 4, 01-163 Warsaw, Poland
 
CITATIONS (2):
1. Suckling and Salsolinol Attenuate Responsiveness of the Hypothalamic-Pituitary-Adrenal Axis to Stress: Focus on Catecholamines, Corticotrophin-Releasing Hormone, Adrenocorticotrophic Hormone, Cortisol and Prolactin Secretion in Lactating Sheep
M. Hasiec, D. Tomaszewska-Zaremba, T. Misztal
Journal of Neuroendocrinology
2. Nonsurgical Management of Hyperadrenocorticism in Ferrets
Sue Chen, Dennis Michels, Erin Culpepper
Veterinary Clinics of North America: Exotic Animal Practice
ISSN:1230-1388