ORIGINAL PAPER
Peripheral ghrelin inhibits feed intake through hypothalamo-pituitary-adrenal axis-dependent mechanism in chicken
1
University of Agriculture of Krakow, Department of Animal Physiology and Endocrinology,
Al. Mickiewicza 24/28, 30-059 Kraków
2
The National Research Institute of Animal Production,
Department of Animal Nutrition and Feed Science,
32-083 Balice/Kraków
Publication date: 2011-03-12
Corresponding author
E. Ocłoń
University of Agriculture of Krakow, Department of Animal Physiology and Endocrinology, Al. Mickiewicza 24/28, 30-059 Kraków
University of Agriculture of Krakow, Department of Animal Physiology and Endocrinology, Al. Mickiewicza 24/28, 30-059 Kraków
J. Anim. Feed Sci. 2011;20(1):118–130
KEYWORDS
ABSTRACT
It is known that centrally injected ghrelin is an anorexigenic peptide in chicken. Its activity is not mediated by NPY/AgRP - producing neurons but through the corticosterone releasing hormone (CRH) - expressing neurons in hypothalamus which activate the hypothalamo-pituitary-adrenal (HPA) axis inducing an increase in plasma corticosterone levels. However, controversial results of peripheral ghrelin effect on appetite have been reported. Thus, the influence of intraperitoneal-injected ghrelin on the activity of the HPA axis in Cobb broiler chickens was examined. In addition, the effect of glucocorticoids antagonist (RU486) on the ghrelin activity was also investigated. The intraperitoneal co-injection of CRH-receptor antagonist, astressin, partially attenuated ghrelin-induced anorexia and corticosterone release. Co-administration of RU486 significantly enhanced the inhibitory effect of ghrelin on feed intake in 7-day- old broiler chickens. These results indicate that the peripheral ghrelin - induced anorexia is caused by the stimulation of HPA axis in chickens.
CITATIONS (25):
1.
Gut Hormones and Regulation of Food Intake in Birds
Kazuhisa Honda, Takaoki Saneyasu, Hiroshi Kamisoyama
The Journal of Poultry Science
Kazuhisa Honda, Takaoki Saneyasu, Hiroshi Kamisoyama
The Journal of Poultry Science
2.
Effects of development and delayed feed access on ghrelin expression in neonatal broiler chickens
Y. Yu, Y. H. Zhang, H. H. Zhang, H. Tao, C. B. Ou, Q. X. Wang, F. Guo, J. Y. Ma
Poultry Science
Y. Yu, Y. H. Zhang, H. H. Zhang, H. Tao, C. B. Ou, Q. X. Wang, F. Guo, J. Y. Ma
Poultry Science
3.
Corticosterone, food intake and refueling in a long-distance migrant
Cas Eikenaar, Franz Bairlein, Mareike Stöwe, Susanne Jenni-Eiermann
Hormones and Behavior
Cas Eikenaar, Franz Bairlein, Mareike Stöwe, Susanne Jenni-Eiermann
Hormones and Behavior
4.
Update on ghrelin biology in birds
Hiroyuki Kaiya, Kenji Kangawa, Mikiya Miyazato
General and Comparative Endocrinology
Hiroyuki Kaiya, Kenji Kangawa, Mikiya Miyazato
General and Comparative Endocrinology
5.
Corticosterone predicts nocturnal restlessness in a long-distance migrant
Cas Eikenaar, Thomas Klinner, Mareike Stöwe
Hormones and Behavior
Cas Eikenaar, Thomas Klinner, Mareike Stöwe
Hormones and Behavior
6.
What is the general action of ghrelin for vertebrates? – Comparisons of ghrelin’s effects across vertebrates
Hiroyuki Kaiya, Kenji Kangawa, Mikiya Miyazato
General and Comparative Endocrinology
Hiroyuki Kaiya, Kenji Kangawa, Mikiya Miyazato
General and Comparative Endocrinology
7.
Ghrelin affects stopover decisions and food intake in a long-distance migrant
Wolfgang Goymann, Sara Lupi, Hiroyuki Kaiya, Massimiliano Cardinale, Leonida Fusani
Proceedings of the National Academy of Sciences
Wolfgang Goymann, Sara Lupi, Hiroyuki Kaiya, Massimiliano Cardinale, Leonida Fusani
Proceedings of the National Academy of Sciences
8.
Effect of Ghrelin Administration on Serum Corticostrone, T3, T4 and Some Biochemical Indices in the Turkey (Meleagridis gallopova)
Habib Aghdam Shahryar, Alireza Lotfi
International Journal of Peptide Research and Therapeutics
Habib Aghdam Shahryar, Alireza Lotfi
International Journal of Peptide Research and Therapeutics
9.
Stress-induced suppression of neuropeptide Y-induced hunger in anorexic chicks involves corticotrophin-releasing factor signalling and the paraventricular nucleus of the hypothalamus
J. Wang, J. Yi, P. B. Siegel, M. A. Cline, E. R. Gilbert
Journal of Neuroendocrinology
J. Wang, J. Yi, P. B. Siegel, M. A. Cline, E. R. Gilbert
Journal of Neuroendocrinology
10.
Cues, corticosterone and departure decisions in a partial migrant
Cas Eikenaar, Elmar Ballstaedt, Sven Hessler, Thomas Klinner, Florian Müller, Heiko Schmaljohann
General and Comparative Endocrinology
Cas Eikenaar, Elmar Ballstaedt, Sven Hessler, Thomas Klinner, Florian Müller, Heiko Schmaljohann
General and Comparative Endocrinology
11.
Nutrient sensing, taste and feed intake in avian species
Shahram Niknafs, Eugeni Roura
Nutrition Research Reviews
Shahram Niknafs, Eugeni Roura
Nutrition Research Reviews
12.
Ghrelin, corticosterone and the resumption of migration from stopover, an automated telemetry study
Cas Eikenaar, Sven Hessler, Elmar Ballstaedt, Heiko Schmaljohann, Hiroyuki Kaiya
Physiology & Behavior
Cas Eikenaar, Sven Hessler, Elmar Ballstaedt, Heiko Schmaljohann, Hiroyuki Kaiya
Physiology & Behavior
13.
Enteroendocrine profile of α-transducin and α-gustducin immunoreactive cells in the chicken (Gallus domesticus) gastrointestinal tract
M Mazzoni, T B Karunaratne, F Sirri, M Petracci, R De Giorgio, C Sternini, P Clavenzani
Poultry Science
M Mazzoni, T B Karunaratne, F Sirri, M Petracci, R De Giorgio, C Sternini, P Clavenzani
Poultry Science
14.
Effects of IBDV infection on expression of ghrelin and ghrelin-related genes in chicken
Y Yu, Y H Zhang, Z Y Xu, T Y Liu, Q X Wang, C B Ou, J Y Ma
Poultry Science
Y Yu, Y H Zhang, Z Y Xu, T Y Liu, Q X Wang, C B Ou, J Y Ma
Poultry Science
15.
Exendin-4 antagonizes the metabolic action of acylated ghrelinergic signaling in the hypothalamic paraventricular nucleus
Shayan Abtahi, Erin Howell, Jack T. Salvucci, Joshua M.R. Bastacky, David P. Dunn, Paul J. Currie
General and Comparative Endocrinology
Shayan Abtahi, Erin Howell, Jack T. Salvucci, Joshua M.R. Bastacky, David P. Dunn, Paul J. Currie
General and Comparative Endocrinology
16.
Biology of the Gastrointestinal Tract in Poultry
Colin G. Scanes, Krystyna Pierzchala-Koziec
Avian Biology Research
Colin G. Scanes, Krystyna Pierzchala-Koziec
Avian Biology Research
17.
Effect of Ghrelin and Ration Composition on Milk Output and Feed Intake in Rabbits
Dorota Kowalsk, Mariusz Pietras, Paweł Bielański
Annals of Animal Science
Dorota Kowalsk, Mariusz Pietras, Paweł Bielański
Annals of Animal Science
18.
The effect of peripheral administration of ghrelin on the performance of growing geese
Shahryar Aghdam, A. Lotfi
Archives Animal Breeding
Shahryar Aghdam, A. Lotfi
Archives Animal Breeding
19.
Effects of peripheral administration of ghrelin antagonist [D-Lys<sup>3</sup>]-GHRP-6 on growth performance and blood biochemical indices in broiler chickens
Shahryar Aghdam, Alireza Lotfi
Archives Animal Breeding
Shahryar Aghdam, Alireza Lotfi
Archives Animal Breeding
20.
Regulating appetite in broilers for improving body and muscle development - A review
Pas te, Randy Borg, Nico Buddiger, Benjamin Wood, Johanna Rebel, Krimpen van, Mario Calus, Jong-Eun Park, Dirkjan Schokker
Journal of Animal Physiology and Animal Nutrition
Pas te, Randy Borg, Nico Buddiger, Benjamin Wood, Johanna Rebel, Krimpen van, Mario Calus, Jong-Eun Park, Dirkjan Schokker
Journal of Animal Physiology and Animal Nutrition
21.
Ghrelin Attenuates Infectious Bursal Disease Virus Induced Early Inflammatory Response and Bursal Injury in Chicken
Yan Yu, Zhiyong Xu, Yanhong Zhang, Qiuxia Wang, Changbo Ou, Yimin Wang, Li Wang, Pei Gao, Shouyang Du, Feng Guo, Jinyou Ma
Poultry Science
Yan Yu, Zhiyong Xu, Yanhong Zhang, Qiuxia Wang, Changbo Ou, Yimin Wang, Li Wang, Pei Gao, Shouyang Du, Feng Guo, Jinyou Ma
Poultry Science
22.
Systemic infusion of exogenous ghrelin in male broiler chickens (Gallus gallus domesticus). The effect of pulse frequency, doses, and ghrelin forms on feed intake, average daily gain, corticosterone, and growth hormone concentrations
N.O. Taofeek, N. Chimbetete, N. Ceron-Romero, F. Vizcarra, M. Verghese, J.A Vizcarra
Poultry Science
N.O. Taofeek, N. Chimbetete, N. Ceron-Romero, F. Vizcarra, M. Verghese, J.A Vizcarra
Poultry Science
23.
Effect of chronic heat stress on gastrointestinal histology and expression of feed intake-regulatory hormones in broiler chickens
M. Mazzoni, M. Zampiga, P. Clavenzani, G. Lattanzio, C. Tagliavia, F. Sirri
animal
M. Mazzoni, M. Zampiga, P. Clavenzani, G. Lattanzio, C. Tagliavia, F. Sirri
animal
24.
Role of leptin and ghrelin in regulation of physiological functions of chicken
Shanmugam Murugesan, Anand Nidamanuri
World's Poultry Science Journal
Shanmugam Murugesan, Anand Nidamanuri
World's Poultry Science Journal
25.
Applications of Enteroendocrine Cells (EECs) Hormone: Applicability on Feed Intake and Nutrient Absorption in Chickens
Jihwan Lee, Woo Kim
Animals
Jihwan Lee, Woo Kim
Animals
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