Modelling endogenous leucine flows at the jejunum and ileum in lambs exposed to the intestinal parasite Trichostrongylus colubriformis
F. Yu 2
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Biomathematics and Statistics Scotland, Bucksburn, Aberdeen, AB21 9SB, UK
Rowett Research Institute, Bucksburn, Aberdeen, AB21 9SB, UK
Moredun Research Institute, Pentlands Science Park, Penicuik, Midlothian EH26 0PZ, UK
Publication date: 2004-10-25
Corresponding author
G. Holtrop   

Biomathematics and Statistics Scotland, Bucksburn, Aberdeen, AB21 9SB, UK
J. Anim. Feed Sci. 2004;13(4):589-603
A mathematical model is presented that compartmentalizes endogenous secretions into the gastro-intestinal tract, according to site of origin. This model was applied to data from three growing lambs (initial liveweight 25-30 kg) given a daily dose of 2500 Trichostrongylus colubriformis larvae for 12 weeks. At weeks 0, 6 and 12 of infection, endogenous leucine flows were determined during an 8 d intra-jugular infusion of [1-13C]leucine, with samples taken from the jejunum, ileum and plasma. The infection had no effect on jejunal leucine flow (102.1 vs 105.5 mmol/d), but ileal leucine flow increased from 18.6 to 26.3 mmol/d (P=0.023). Endogenous leucine flow at the jejunum was unaffected by the infection (15.0 vs 18.9 mmol/d; P=0.116) but was doubled at the ileum (5.5 vs 10.4 mmol/d; P=0.025). Secretions into the small intestine contributed 58 (controls) to 65% (parasites) of ileal endogenous flow. The model also predicted that net portal drained viscera appearance was, at maximum, 79% of net appearance in the mesenteric vein.
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