Parasitological examinations and the investigation of polymorphism in locus DRB1, belonging to
MHC class II, were conducted in a flock of Polish Heath Sheep in the years 1995-1998. The intensity
of parasite infection of dams ranged from 0 to 24 000 eggs, whereas for lambs it reached up to 27 000
nematode eggs in 1 gram of faeces. In the years 1995-1997 nematode species dominant in the infection
were H.contortus and T. colubriformis, while in 1998 the predominant was T. circumcincta.
DNA analysis of the examined sheep showed the presence of 20 alleles in locus DRB1, established
on the basis of the length of a fragment of this gene amplified using PCR (exon 2 and microsatellite
in intron 2).
The analysis of variance conducted for the FEC trait in genotypic groups showed a statistically
significant (P<0.01) association between the genotype in locus DRB1 and number of nematode eggs
in sheep faeces. The presence of a given DRB1 allele in the genotype of animals examined had
significant effect on parasite resistance. Moreover, the significant association between the FEC value
in allelic groups of paternal half-sibs and the segregation of paternal alleles was also significant
(P<0.05).
CITATIONS(24):
1.
Quantitative trait loci associated with parasitic infection in Scottish blackface sheep G Davies, M J Stear, M Benothman, O Abuagob, A Kerr, S Mitchell, S C Bishop Heredity
Quantitative trait loci for resistance toHaemonchus contortusartificial challenge in Red Maasai and Dorper sheep of East Africa K. Marshall, J. M. Mugambi, S. Nagda, T. S. Sonstegard, C. P. Van Tassell, R. L. Baker, J. P. Gibson Animal Genetics
MHC-DQB1 Variation and Its Association with Resistance or Susceptibility to Cystic Echinococcosis in Chinese Merino Sheep Wenqiao Hui, Hong Shen, Song Jiang, Bin Jia Asian-Australasian Journal of Animal Sciences
Associations between blood parasite infection and a microsatellite DNA allele in an Australian scincid lizard (Egernia stokesii) Stephanie S. Godfrey, C. Michael Bull, Michael G. Gardner Parasitology Research
‘Ovar-Mhc‘— Ovine major histocompatibility complex: Role in genetic resistance to diseases VSR Dukkipati, HT Blair, DJ Garrick, A Murray New Zealand Veterinary Journal
A quantitative trait locus for faecal worm egg and blood eosinophil counts on chromosome 23 in Australian goats S. Bolormaa, J.H.J. Van Der Werf, S.W. Walkden-Brown, K Marshall, A. Ruvinsky Journal of Animal Breeding and Genetics
Association between major histocompatibility complex microsatellites, fecal egg count, blood packed cell volume and blood eosinophilia in Pelibuey sheep infected with Haemonchus contortus Juan Antonio Figueroa Castillo, Rubén Danilo Méndez Medina, José Manuel Berruecos Villalobos, Amanda Gayosso-Vázquez, Raúl Ulloa-Arvízu, Rebeca Acosta Rodríguez, Hugo Pérez Ramírez, Rogelio A. Alonso Morales Veterinary Parasitology
Fecal egg counts for gastrointestinal nematodes are associated with a polymorphism in the MHC-DRB1 gene in the Iranian Ghezel sheep breed Rahman Hajializadeh Valilou, Seyed A. Rafat, David R. Notter, Djalil Shojda, Gholamali Moghaddam, Ahmad Nematollahi Frontiers in Genetics
Gastrointestinal nematode infection in sheep – a review of the alternatives to anthelmintics in parasite control G. Sayers, T. Sweeney Animal Health Research Reviews
Genetic variation for worm burdens in laying hens naturally infected with gastro-intestinal nematodes K. Wongrak, G. Daş, U. König von Borstel, M. Gauly British Poultry Science
The dynamic influence of genetic variation on the susceptibility of sheep to gastrointestinal nematode infection M. J Stear, L. Fitton, G. T Innocent, L. Murphy, K. Rennie, L. Matthews Journal of The Royal Society Interface
Confirmation of two quantitative trait loci regions for nematode resistance in commercial British terminal sire breeds O. Matika, R. Pong-Wong, J. A. Woolliams, S. C. Bishop animal
Effect of Ovar-DRA
and Ovar-DRB1
genotype in small ruminants with haemonchosis Z. M. Estrada-Reyes, Y. Tsukahara, A. L. Goetsch, T. A. Gipson, T. Sahlu, R. Puchala, Z. Wang, S. P. Hart, R. G. Mateescu Parasite Immunology
Genetic characterization of some Turkish sheep breeds based on the sequencing of the <i>Ovar-DRB1</i> gene in the major histocompatibility complex (MHC) gene region Fulya Özdil, Fatma İlhan, Raziye Işık Archives Animal Breeding
The evolution and maintenance of polymorphism in the major histocompatibility complex M.J. Stear, G.T. Innocent, J. Buitkamp Veterinary Immunology and Immunopathology
Detection of genes with moderate effects on disease resistance using ovine mhc and resistance to nematodes as an example M.J. Stear, A. Belch, K. Donskow-Schmelter, L.A. Fitton, G.T. Innocent, C. Ishikane, A. Mateus, L. Murphy, K. Rennie, A. Smith, G. Sayers Veterinary Immunology and Immunopathology
Allele substitution and dominance effects of CD166/ALCAM gene polymorphisms for endoparasite resistance and test-day traits in a small cattle population using logistic regression analyses Katharina May, Christina Weimann, Carsten Scheper, Christina Strube, Sven König Mammalian Genome
Discovery of quantitative trait loci for resistance to parasitic nematode infection in sheep: I. Analysis of outcross pedigrees Allan Crawford, Korena Paterson, Ken Dodds, Tascon Diez, Penny Williamson, Thomson Roberts, Stewart Bisset, Anne Beattie, Gordon Greer, Richard Green, Roger Wheeler, Richard Shaw, Kevin Knowler, John McEwan BMC Genomics
Polymorphism of Selected Regions of Ovar-MHC and the Health Status of the Ovine Mammary Gland Wiesław Świderek, Joanna Gruszczyńska, Anna Winnicka Animals
A novel 2 bp deletion variant in Ovine-DRB1 gene is associated with increased Visna/maedi susceptibility in Turkish sheep Yalçın Yaman, Veysel Bay, Ramazan Aymaz, Murat Keleş, Yasemin Öner, Eden Teferedegn, Cemal Ün Scientific Reports
Caprine haemonchosis: optimism of breeding for disease resistance in developing countries Kush Shrivastava, Ajit Singh, Kajal Jadav, Sanjay Shukla, Sita Tiwari Journal of Applied Animal Research
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.