Effect of nutrients on p70S6K activation in the bovine mammary gland
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Department of Animal and Poultry Science, University of Guelph, Guelph, ON, N1G 2W1,Canada
Department of Clinical Studies, University of Guelph, Guelph, ON, N1G 2W1,Canada
Publication date: 2004-08-30
Corresponding author
C. A. Toerien   

Department of Animal and Poultry Science, University of Guelph, Guelph, ON, N1G 2W1,Canada
J. Anim. Feed Sci. 2004;13(Suppl. 1):449-452
The effect of jugular infusions of glucose and amino acids on activation of p70S6K was studied in the bovine mammary gland. Cows were starved for 22 h to quench milk protein synthesis before resupplying EEA+Glc, Glc, Met+Lys, His, Leu or saline. Results implicate glucose as a regulator of global, rather than ribosomal, protein synthesis. EAA appear to play a far greater role in p70S6K regulation than glucose. His and Leu appear to act as metabolic agents in the mammary epithelial cell; Leu through elevating RNA levels thereby contributing to the long-term protein synthesis capacity, and His through stimulating protein translation.
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