SHORT COMMUNICATION
Effect of nutrients on p70S6K activation in the bovine mammary gland
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1
Department of Animal and Poultry Science, University of Guelph, Guelph, ON, N1G 2W1,Canada
2
Department of Clinical Studies, University of Guelph, Guelph, ON, N1G 2W1,Canada
CORRESPONDING AUTHOR
C. A. Toerien   

Department of Animal and Poultry Science, University of Guelph, Guelph, ON, N1G 2W1,Canada
Publication date: 2004-08-30
 
J. Anim. Feed Sci. 2004;13(Suppl. 1):449–452
 
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ABSTRACT
The effect of jugular infusions of glucose and amino acids on activation of p70S6K was studied in the bovine mammary gland. Cows were starved for 22 h to quench milk protein synthesis before resupplying EEA+Glc, Glc, Met+Lys, His, Leu or saline. Results implicate glucose as a regulator of global, rather than ribosomal, protein synthesis. EAA appear to play a far greater role in p70S6K regulation than glucose. His and Leu appear to act as metabolic agents in the mammary epithelial cell; Leu through elevating RNA levels thereby contributing to the long-term protein synthesis capacity, and His through stimulating protein translation.
 
CITATIONS (1):
1.
Nutrient availability and lactogenic hormones regulate mammary protein synthesis through the mammalian target of rapamycin signaling pathway
S.A. Burgos, M. Dai, J.P. Cant
Journal of Dairy Science
 
ISSN:1230-1388