ORIGINAL PAPER
A diet rich in menhaden oil has the hypolipidemic effect but increases plasma glucose and insulin levels in rats
1
Medical University of Lodz, Department of Cell-to-Cell Communication, Mazowiecka 6/8, 92-215 Łódź, Poland
Publication date: 2019-03-05
Corresponding author
B. Dziedzic
Medical University of Lodz, Department of Cell-to-Cell Communication, Mazowiecka 6/8, 92-215 Łódź, Poland
Medical University of Lodz, Department of Cell-to-Cell Communication, Mazowiecka 6/8, 92-215 Łódź, Poland
J. Anim. Feed Sci. 2019;28(1):62-68
KEYWORDS
TOPICS
ABSTRACT
A composition of dietary fat considerably affects the metabolism of
nutrients, especially high-fat diet is associated with various metabolic disorders,
diabetes and cardiovascular diseases in humans. Studies on rodents are an
established model to investigate the pathophysiology of excessive fat in diets,
hence the aim of the study was to evaluate the effect of dietary fats different
in composition on plasma lipids, glucose and insulin levels in non-genetically
modified rats instead of genetic models of obesity or diabetes. Animals were
fed purified low- or high-fat (12 and 40% energy from fat, respectively) diets
containing the same fat sources – lard, sunflower oil or menhaden oil for six
weeks. Feeding menhaden oil, both in low- and high-fat diets, resulted in
decreased plasma triglyceride, total cholesterol and high-density lipoprotein
cholesterol levels in comparison to diets composed of lard or sunflower oil.
However, high-fat diet with menhaden oil caused an increase in plasma glucose
and insulin levels, which resulted in the increased HOMA-IR (Homeostatic
Model Assessment – Insulin Resistance) index in relation to low-fat diet with the
same oil. The obtained results demonstrate that high menhaden oil intake has
the hypolipidemic effect but can impair glucose homeostasis in non-genetically
modified rats.
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