0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
0.405
SJR
Q2
SJR
20
MNiSW
165.24
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

Diurnal and seasonal changes in IL-6 and IL-18 gene expression in blood leukocytes of male chickens with experimental peritonitis: the impact of lighting conditions and melatonin

E. Turkowska 1  ,  
S. Rai 2, 3,  
 
1
University of Warsaw, Faculty of Biology, Department of Animal Physiology, Miecznikowa 1, 02-096, Warsaw, Poland
2
Department of Zoology, School of Life Sciences, Guru Ghasidas Vishwavidyalaya, 495 009 Bilaspur, Chhattisgarh, India
3
Dr. Seema Rai was a Visiting Scientist at the University of Warsaw, Poland, under the INSA-PAS Bilateral Exchange 2012 programme.
J. Anim. Feed Sci. 2013;22(2):149–157
Publish date: 2013-06-17
KEYWORDS
ABSTRACT
The aim of this study was to examine the involvement of melatonin in the photoperiod-related development of inflammation in chickens. Newly hatched birds obtained in summer and winter were kept in a light : dark (LD) cycle (corresponding to the season of hatch) or in continuous light (LL). Half of the chickens held under LL conditions were given melatonin during the subjective night. Peritonitis was evoked on the 12th day of life by thioglycollate (TG) injection at the beginning or towards the end of the subjective day and the effect was measured 4 h later, i.e. during the day or at night. The development of inflammation was evaluated by the number of peritoneal leukocytes (PTLs) inflowing to the peritoneal cavity and by the level of mRNAs encoding proinflammatory cytokines in the blood leukocytes. Day/night differences in PTL number were seen only in the summer, regardless of the experimental conditions. In chickens kept under LL conditions and given melatonin, TG injection caused an increase in interleukin-6 (IL-6) mRNA level in blood leukocytes in summer and a decrease in winter. Neither experimental conditions nor circadian time affected the interleukin-18 (IL-18) mRNA level in summer, whereas in winter abundance of this transcript exhibited the daily variations and the influence of the treatment. The obtained results suggest the existence of clockcontrolled diurnal and seasonal variability of the chicken inflammatory reaction, which is influenced in different ways by circulating melatonin.
CORRESPONDING AUTHOR
E. Turkowska   
University of Warsaw, Faculty of Biology, Department of Animal Physiology, Miecznikowa 1, 02-096, Warsaw, Poland
 
CITATIONS (5):
1. Seasonal postembryonic maturation of the diurnal rhythm of serotonin in the chicken pineal gland
Aneta Piesiewicz, Urszula Kedzierska, Elzbieta Turkowska, Iwona Adamska, Pawel M. Majewski
Chronobiology International
2. Pineal oscillator functioning in the chicken – Effect of photoperiod and melatonin
Elzbieta Turkowska, Pawel M. Majewski, Seema Rai, Krystyna Skwarlo-Sonta
Chronobiology International
3. Seasonality of inflammation in the chicken: clock vs. melatonin control over the pro-inflammatory cytokine gene transcription
Elzbieta Turkowska, Iwona Adamska, Sylwia Niedziolka, Pawel Marek Majewski, Krystyna Skwarlo-Sonta
Biological Rhythm Research
4. Thymic E4bp4 gene transcription is up-regulated in the chicken during experimental peritonitis modified by the season-related lighting conditions
Elzbieta Turkowska, Dominika Pietruszka, Krystyna Skwarlo-Sonta
Developmental & Comparative Immunology
5. Avian biological clock – Immune system relationship
Magdalena Markowska, Paweł M. Majewski, Krystyna Skwarło-Sońta
Developmental & Comparative Immunology
ISSN:1230-1388