ORIGINAL PAPER
Antimicrobial peptides as an additive in broiler chicken nutrition:
a meta-analysis of bird performance, nutrient digestibility
and serum metabolites
1
IPB University, Graduate School of Nutrition and Feed Science, Bogor, Indonesia
2
Sultan Syarif Kasim State Islamic University, Department of Animal Science, Pekanbaru 28293, Indonesia
3
Universitas Sebelas Maret, Vocational Program in Animal Husbandry, Surakarta 57126, Indonesia
4
Asessment Institute of Agriculture Technology, South Sulawesi, Indonesia
5
IPB University, Faculty of Mathematics and Natural Sciences, Department Biology, Bogor, Indonesia
6
Chiba University, Faculty of Education Chiba, Training Division for School Health Nursing (Yogo) Teachers, Japan
7
IPB University, Faculty of Animal Science, Department of Nutrition and Feed Technology, Bogor, Indonesia
Publication date: 2021-05-29
Corresponding author
A. Jayanegara
IPB University, Faculty of Animal Science, Department of Nutrition and Feed Technology, Bogor, Indonesia
IPB University, Faculty of Animal Science, Department of Nutrition and Feed Technology, Bogor, Indonesia
J. Anim. Feed Sci. 2021;30(2):100-110
KEYWORDS
TOPICS
ABSTRACT
The present meta-analysis evaluated the effect of the level
of antimicrobial peptides (AMPs) on broiler chicken growth performance,
digestibility, small intestine morphology and blood serum parameters. The
database was developed from 29 articles comprising 36 experiments. Data
were analyzed using a mixed model methodology considering the levels of
AMPs as fixed effects and different studies as random effects. It was shown
that an increased AMPs addition level quadratically influenced body weight
(BW), average daily gain (ADG) and feed conversion ratio (FCR) (P < 0.05).
Simultaneously, it linearly reduced mortality (P < 0.05) both in the starter
and finisher periods. There was a linear increase in metabolizable energy
(P < 0.05). Small intestine morphology in the duodenum, as indicated by villus
height and villus height to crypt depth ratio linearly increased, while the crypt
depth was linearly decreased (P < 0.05). The mucosa thickness was quadratically
affected in the jejunum, while the crypt depth linearly decreased (P < 0.05).
Categorical analysis showed that AMPs had a comparable effect with antibiotics
on broiler performance (BW, ADG, FCR) (P > 0.05); a similar
improvement was shown in the control group (P < 0.01). In conclusion, it is
evidenced that AMPs can be used as an effective replacer of antibiotic growth
promoters (AGP) because they can improve growth performance, digestibility,
small intestine morphology and blood serum parameters of broiler in all
rearing periods. Also, the optimal doses of dietary AMPs addition at 337 and
359 mg/kg of diet for the starter and finisher phases, respectively, are suggested.
ACKNOWLEDGEMENTS
This study was fully funded by the Ministry of Education and Culture, the Republic of Indonesia, through the scholarship research scheme, namely ‘Master Education Towards Doctor for Excellent Bachelor (PMDSU)’ grant no. 2136/IT3.L1 PN/2021 in the 2021 fiscal year. This paper was also a part of the sandwich-like program (PKPI) grand number T/2134/D3.2/Kd.02.00/2019 at Chiba University, Japan in 2019.
CONFLICT OF INTEREST
The authors declare that there is no conflict of interest.
REFERENCES (62)
1.
Abdel-Latif M.A., El-Far A.H., Elbestawy A.R., Ghanem R., Mousa S.A., Abd El-Hamid H.S., 2017. Exogenous dietary lysozyme improves the growth performance and gut microbiota in broiler chickens targeting the antioxidant and non-specific immunity mRNA expression. PLoS ONE 12, e0185153, http://doi.org/10.1371/journal....
2.
Aguirre A.T.A., Acda S.P., Angeles A.A., Oliveros M.C.R., Merca F.E., Cruz F.A., 2015. Effect of bovine lactoferrin on growth performance and intestinal histologic features of broilers. Philipp. J. Vet. Anim. Sci. 41, 12–20.
3.
Ali A.H.H., Mohanny K.M., 2014. Effect of injection with bee venom extract on productive performance and immune response of broiler chicks. J. Anim. Poult. Prod. 5, 237–246, https://doi.org/10.21608/jappm....
4.
Aliakbarpour H.R., Chamani M., Rahimi G., Sadeghi A.A., Qujeq D., 2012. The Bacillus subtilis and lactic acid bacteria probiotics influences intestinal mucin gene expression, histomorphology and growth performance in broilers. Asian-Australas. J. Anim. Sci. 25, 1285–1293, http://doi.org/10.5713/ajas.20....
5.
Bai J., Wang R., Yan L., Feng J., 2019. Co-supplementation of dietary seaweed powder and antibacterial peptides improves broiler growth performance and immune function. Braz. J. Poult. Sci. 21, eRBCA-2018-0826, https://doi.org/10.1590/1806-9....
6.
Bao H., She R., Liu T. et al., 2009. Effects of pig antibacterial peptides on growth performance and intestine mucosal immune of broiler chickens. Poult. Sci. 88, 291–297, https://doi.org/10.3382/ps.200....
7.
Bauer E., Jakob S., Mosenthin R., 2005. Principles of physiology of lipid digestion. Asian-Australas. J. Anim. Sci. 18, 282–295, https://doi.org/10.5713/ajas.2....
8.
Choi S.C., Ingale S.L., Kim J.S., Park Y.K., Kwon I.K., Chae B.J., 2013a. An antimicrobial peptide-A3: effects on growth performance, nutrient retention, intestinal and faecal microflora and intestinal morphology of broilers. Br. Poult. Sci. 54, 738–746, https://doi.org/10.1080/000716....
9.
Choi S.C., Ingale S.L., Kim J.S., Park Y.K., Kwon I.K., Chae B.J., 2013b. Effects of dietary supplementation with an antimicrobial peptide-P5 on growth performance, nutrient retention, excreta and intestinal microflora and intestinal morphology of broilers. Anim. Feed Sci. Technol. 185, 78–84, https://doi.org/10.1016/j.anif....
10.
Daneshmand A., Kermanshahi H., Sekhavati M.H., Javadmanesh A., Ahmadian M., 2019. Antimicrobial peptide, cLF36, affects performance and intestinal morphology, microflora, junctional proteins, and immune cells in broilers challenged with E. coli. Sci. Rep. 9, 14176, https://doi.org/10.1038/s41598....
11.
Daneshmand A., Kermanshahi H., Sekhavati M.H., Javadmanesh A., Ahmadian M., Alizadeh M., Aldavoodi A., 2020. Effects of cLFchimera on intestinal morphology, integrity, microbiota, and immune cells in broiler chickens challenged with necrotic enteritis. Sci. Rep. 10, 17704, https://doi.org/10.1038/s41598....
12.
EFSA (European Food Safety Authority), Bronzwaer S., Kass G., Robinson T., Tarazona J., Verhagen H., Verloo D., Vrbos D., Hugas M., 2019. Editorial on food safety regulatory research needs 2030. EFSA J. 17, e170622, https://doi.org/10.2903/j.efsa....
13.
Enany M., El Gammal A.E.A., Solimane R., El Sissi A., Hebashy A., 2017. Evaluation of lactoferrin immunomodulatory effect on the immune response of broiler chickens. Suez Canal Vet. Med. J. 22, 135–146, https://doi.org/10.21608/scvmj....
14.
Feingold K.R., Grunfeld C., 2000. Introduction to lipids and lipoproteins. In: Endotext. MDText.com, Inc., South Dartmouth, MA (USA).
15.
Geier M.S., Torok V.A., Guo P., Allison G.E., Boulianne M., Janardhana V., Bean A.G.D., Hughes R.J., 2011. The effects of lactoferrin on the intestinal environment of broiler chickens. Br. Poult. Sci. 52, 564–572, https://doi.org/10.1080/000716....
16.
Gong M., Anderson D., Rathgeber B., MacIsaac J., 2017. The effect of dietary lysozyme with EDTA on growth performance and intestinal microbiota of broiler chickens in each period of the growth cycle. J. Appl. Poult. Res. 26, 1–8, https://doi.org/10.3382/japr/p....
17.
Han S.M., Lee K.G., Yeo J.H., Oh B.Y., Kim B.S., Lee W., Baek H.J., Kim S.T., Hwang S.J., Pak S.C., 2010. Effects of honeybee venom supplementation in drinking water on growth performance of broiler chickens. Poult. Sci. 89, 2396–2400, https://doi.org/10.3382/ps.201....
18.
Hu X.F., Guo Y.M., Huang B.Y., Bun S., Zhang L.B., Li J.H., Liu D., Long F.Y., Yang X., Jiao P., 2010. The effect of glucagon-like peptide 2 injection on performance, small intestinal morphology, and nutrient transporter expression of stressed broiler chickens. Poult. Sci. 89, 1967–1974, https://doi.org/10.3382/ps.200....
19.
Irawan A., Hidayat C., Jayanegara A., Ratriyanto A., 2020. Essential oils as growth-promoting additives on performance, nutrient digestibility, cecal microbes, and serum metabolites of broiler chickens: a meta-analysis. Asian-Australas. J. Anim. Sci. https://doi.org/10.5713/ab.20.....
20.
Irawan A., Sofyan A., Ridwan R., Hassim H.A., Respati A.N., Wardani W.W., Sadarman, Astuti W.D., Jayanegara A., 2021. Effects of different lactic acid bacteria groups and fibrolytic enzymes as additives on silage quality: a meta-analysis. Bioresour. Technol. Rep. 14, 100654, https://doi.org/10.1016/j.bite....
21.
Jiang Y.B., Yin Q.Q., Yang Y.R., 2009. Effect of soybean peptides on growth performance, intestinal structure and mucosal immunity of broilers. J. Anim. Physiol. Anim. Nutr. 93, 754–760, https://doi.org/10.1111/j.1439....
22.
Jin Z., Yang Y.X., Choi J.Y. et al., 2008. Effects of potato (Solanum tuberosum L. cv. Golden valley) protein having antimicrobial activity on the growth performance, and intestinal microflora and morphology in weanling pigs. Anim. Feed Sci. Technol. 140, 139–154, https://doi.org/10.1016/j.anif....
23.
Józefiak A., Engberg R.M., 2017. Insect proteins as a potential source of antimicrobial peptides in livestock production. a review. J. Anim. Feed Sci. 26, 87–99, https://doi.org/10.22358/jafs/....
24.
Karimzadeh S., Rezaei M., Teimouri Yansari A., 2016. Effects of canola bioactive peptides on performance, digestive enzyme activities, nutrient digestibility, intestinal morphology and gut microflora in broiler chickens. Poult. Sci. J. 4, 27–36, https://doi.org/10.22069/psj.2....
25.
Karimzadeh S., Rezaei M., Teimouri-Yansari A., 2017a. Effect of canola peptides, antibiotic, probiotic and prebiotic on performance, digestive enzymes activity and some ileal aerobic bacteria in broiler chicks. Iran J. Anim. Sci. 48, 129–139, https://doi.org/10.22059/ijas.....
26.
Karimzadeh S., Rezaei M., Yansari A.T., 2017b. Effects of different levels of canola meal peptides on growth performance and blood metabolites in broiler chickens. Livest. Sci. 203, 37–40, https://doi.org/10.1016/j.livs....
27.
Kierończyk B., Rawski M., Mikołajczak Z., Świątkiewicz S., Józefiak D., 2020. Nisin as a novel feed additive: The effects on gut microbial modulation and activity, histological parameters, and growth performance of broiler chickens. Animals 10, 101, https://doi.org/10.3390/ani100....
28.
Kim D.H., Han S.M., Keum M.C., Lee S., An B.K., Lee S.-R., Lee K.-W., 2018. Evaluation of bee venom as a novel feed additive in fast-growing broilers. Br. Poult. Sci. 59, 435–442, https://doi.org/10.1080/000716....
29.
Leeson S., Summers J.D., 2009. Commercial Poultry Nutrition. Nottingham University Press. Nottingham (UK), https://doi.org/10.7313/UPO978...
30.
Li Z., Mao R., Teng D., Hao Y., Chen H., Wang X., Wang X., Yang N., Wang J., 2017. Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus. Sci. Rep. 7, 12124, https://doi.org/10.1038/s41598....
31.
Liu D., Guo Y., Wang Z., Yuan J., 2010. Exogenous lysozyme influences Clostridium perfringens colonization and intestinal barrier function in broiler chickens. Avian Pathol. 39, 17–24, https://doi.org/10.1080/030794....
32.
Ma J.L., Zhao L.H., Sun D.D., Zhang J., Guo Y.P., Zhang Z.Q., Ma Q.G., Ji C., Zhao L.H., 2020. Effects of dietary supplementation of recombinant plectasin on growth performance, intestinal health and innate immunity response in broilers. Probiotics Antimicrob. Proteins 12, 214–223, https://doi.org/10.1007/s12602....
33.
Magana M., Pushpanathan M., Santos A.L. et al., 2020. The value of antimicrobial peptides in the age of resistance. Lancet Infect. Dis. 20, E216–E230, https://doi.org/10.1016/S1473-....
34.
Ohh S.H., Shinde P.L., Jin Z., Choi J.Y., Hahn T.-W., Lim H.T., Kim G.Y., Park Y., Hahm K.-S., Chae B.J., 2009. Potato (Solanum tuberosum L. cv. Gogu valley) protein as an antimicrobial agent in the diets of broilers. Poult. Sci. 88, 1227–1234, https://doi.org/10.3382/ps.200....
35.
Pinheiro J., Bates D., DebRoy S. et al., 2020. nlme: Linear and Nonlinear Mixed Effects Models, https://cran.r-project.org/web....
36.
Prihambodo T., Sholikin M.M., Qomariyah N., et al., 2021. Effects of dietary flavonoids on performance, blood constituents, carcass composition and small intestinal morphology of broilers: a meta-analysis. Anim. Biosci. 34, 434–442, https://doi.org/10.5713/ajas.2....
37.
R Core Team, 2020. R: a Language and Environment for Statistical Computing. R Foundation for Statistical Computing. Vienna (Austria), http://www.r-project.org/index....
38.
Saks V.A., Ventura-Clapier, R. (Editors), 1994. Cellular Bioenergetics: Role of Coupled Creatine Kinases. Springer Science+Business Media. Dordrecht (the Netherlands), https://doi.org/10.1007/978-1-....
39.
Salavati M.E., Rezaeipour V., Abdullahpour R., Mousavi N., 2020. Effects of graded inclusion of bioactive peptides derived from sesame meal on the growth performance, internal organs, gut microbiota and intestinal morphology of broiler chickens. Int. J. Pept. Res. Ther. 26, 1541–1548, https://doi.org/10.1007/s10989....
40.
Sauvant D., Schmidely P., Daudin J.J., St-Pierre N.R., 2008. Meta-analyses of experimental data in animal nutrition. Animal 2, 1203–1214, https://doi.org/10.1017/s17517....
41.
Selle P.H., Ravindran V., Ravindran G., Bryden W.L., 2007. Effects of dietary lysine and microbial phytase on growth performance and nutrient utilisation of broiler chickens. Asian-Australas. J. Anim. Sci. 20, 1100–1107, https://doi.org/10.5713/ajas.2....
42.
Skosyrev V.S., Kulesskiy E.A., Yakhnin A.V., Temirov Y.V., Vinokurov L.M., 2003. Expression of the recombinant antibacterial peptide sarcotoxin IA in Escherichia coli cells. Protein Expr. Purif. 28, 350–356, https://doi.org/10.1016/s1046-....
43.
St-Pierre N.R., 2001. Invited review: integrating quantitative findings from multiple studies using mixed model methodology. J. Dairy Sci. 84, 741–755, https://doi.org/10.3168/jds.s0....
44.
Svihus B., 2014. Function of the digestive system. J. Appl. Poult. Res. 23, 306–314, https://doi.org/10.3382/japr.2....
45.
Tanhaeian A., Mirzaii M., Pirkhezranian Z., Sekhavati M.H., 2020. Generation of an engineered food-grade Lactococcus lactis strain for production of an antimicrobial peptide: in vitro and in silico evaluation. BMC Biotechnol. 20, 19, https://doi.org/10.1186/s12896....
46.
Tanhaiean A., Azghandi M., Razmyar J., Mohammadi E., Sekhavati M.H., 2018a. Recombinant production of a chimeric antimicrobial peptide in E. coli and assessment of its activity against some avian clinically isolated pathogens. Microb. Pathog. 122, 73–78, https://doi.org/10.1016/j.micp....
47.
Tanhaieian A., Sekhavati M.H., Ahmadi F.S., Mamarabadi M., 2018b. Heterologous expression of a broad-spectrum chimeric antimicrobial peptide in Lactococcus lactis: Its safety and molecular modeling evaluation. Microb. Pathog. 125, 51–59, https://doi.org/10.1016/j.micp....
48.
Torki M., Schokker D., Duijster-Lensing M., Van Krimpen M.M., 2018. Effect of nutritional interventions with quercetin, oat hulls, β-glucans, lysozyme and fish oil on performance and health status related parameters of broilers chickens. Br. Poult. Sci. 59, 579–590, https://doi.org/10.1080/000716....
49.
Vanrolleghem W., Tanghe S., Verstringe S., Bruggeman G., Papadopoulos D., Trevisi P., Zentek J., Sarrazin S., Dewulf J., 2019. Potential dietary feed additives with antibacterial effects and their impact on performance of weaned piglets: a meta-analysis. Vet. J. 249, 24–32, http://doi.org/10.1016/j.tvjl.....
50.
Wang D., Ma W., She R., Sun Q., Liu Y., Hu Y., Liu L., Yang Y., Peng K., 2009. Effects of swine gut antimicrobial peptides on the intestinal mucosal immunity in specific-pathogen-free chickens. Poult. Sci. 88, 967–974, https://doi.org/10.3382/ps.200....
51.
Wang S., Zeng X.F., Wang Q.W., et al., 2015. The antimicrobial peptide sublancin ameliorates necrotic enteritis induced by Clostridium perfringens in broilers. J. Anim. Sci. 93, 4750–4760. https://doi.org/10.2527/jas.20....
52.
Wang G., Song Q., Huang S., Wang Y., Cai S., Yu H., Ding X., Zeng X., Zhang J., 2020. Effect of antimicrobial peptide microcin J25 on growth performance, immune regulation, and intestinal microbiota in broiler chickens challenged with Escherichia coli and Salmonella. Animals 10, 345, https://doi.org/10.3390/ani100....
53.
Wang S., Zeng X., Yang Q., Qiao S., 2016. Antimicrobial peptides as potential alternatives to antibiotics in food animal industry. Int. J. Mol. Sci. 17, 603, https://doi.org/10.3390/ijms17....
54.
Wang Y., Shan T., Xu Z., Liu J., Feng J., 2006. Effect of lactoferrin on the growth performance, intestinal morphology, and expression of PR-39 and protegrin-1 genes in weaned piglets. J. Anim. Sci. 84, 2636–2641, https://doi.org/10.2527/jas.20....
55.
Wen L.-F., He J.-G., 2012. Dose-response effects of an antimicrobial peptide, a cecropin hybrid, on growth performance, nutrient utilisation, bacterial counts in the digesta and intestinal morphology in broilers. Br. J. Nutr. 108, 1756–1763, https://doi.org/10.1017/S00071....
56.
Xiao H., Shao F., Wu M., Ren W., Xiong X., Tan B., Yin Y., 2015. The application of antimicrobial peptides as growth and health promoters for swine. J. Anim. Sci. Biotechnol. 6, 19, https://doi.org/10.1186/s40104....
57.
Xiao H., Tan B.E., Wu M.M., Lin Y.L., Li T.J., Yuan D.X, and Li L., 2013. Effects of composite antimicrobial peptides in weanling piglets challenged with deoxynivalenol: II. Intestinal morphology and function. J. Anim. Sci. 91, 4750–4756, https://doi.org/10.2527/jas.20....
58.
Xu B., Fu J., Zhu L., Li Z., Jin M., Wang Y., 2021. Overall assessment of antibiotic substitutes for pigs: a set of meta-analyses. J. Anim. Sci. Biotechnol. 12, 3, http://doi.org/10.1186/s40104-....
59.
Yi H.-Y., Chowdhury M., Huang Y.-D., Yu X.-Q., 2014. Insect antimicrobial peptides and their applications. Appl. Microbiol. Biotechnol. 98, 5807–5822, https://doi.org/10.1007/s00253....
60.
Yoon J.H., Ingale S.L., Kim J.S., Kim K.H., Lohakare J., Park Y.K., Park J.C., Kwon I.K., Chae B.J., 2013. Effects of dietary supplementation with antimicrobial peptide-P5 on growth performance, apparent total tract digestibility, faecal and intestinal microflora and intestinal morphology of weanling pigs. J. Sci. Food Agric. 93, 587–592, https://doi.org/10.1002/jsfa.5....
61.
Zhang G., Mathis G.F., Hofacre C.L., Yaghmaee P., Holley R.A., Duranc T.D., 2010. Effect of a radiant energy-treated lysozyme antimicrobial blend on the control of clostridial necrotic enteritis in broiler chickens. Avian Dis. 54, 1298–1300, https://doi.org/10.1637/9370-0....
62.
Zhao X., Wu H., Lu H., Li G., Huang Q., 2013. LAMP: a database linking antimicrobial peptides. PLoS ONE 8, e66557, https://doi.org/10.1371/journa....
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