0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
0.405
SJR
Q2
SJR
20
MNiSW
165.24
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

The effect of repeated endotoxin injections on gonadotropin secretion in ewes

A. P. Herman 1  ,  
K. Romanowicz 1,  
 
1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
J. Anim. Feed Sci. 2014;23(3):217–221
Publish date: 2014-08-20
KEYWORDS
ABSTRACT
Although it is well known that acute inflammation induced by a single injection of the bacterial endotoxin, lipopolysaccharide (LPS), induces a stress response and suppresses luteinizing hormone (LH) secretion, the effects of repeated endotoxin administration on gonadotropin secretion in sheep have not been studied yet. In this work, the influence of inflammation induced by six days of intravenous LPS injection (400 ng· kg–1 per day) on the release of LH and follicle-stimulating (FSH) hormones was evaluated. Anoestrous ewes were bled twice a day 1 h before and 3 h after LPS injection. Endotoxin injection decreased (P < 0.05) the release of LH from the first day of the experiment. Moreover, on day 5, the suppression of LH secretion was sustained and could also be detected in the samples collected before the next LPS injection. In contrast, elevation (P < 0.05) of FSH release was detected starting from the second dose of the endotoxin. The increased FSH concentration persisted until the end of the experiment. Each LPS injection stimulated (P < 0.05) cortisol release, but from days 3 to 6, this elevation was about three times lower than the level determined during the first two days. The obtained results show that ewes exposed to repeated administration of endotoxin lost their ability to restore proper LH release relatively quickly. This disturbance in gonadotropin secretion could, in part, be associated with the stress induced by LPS, as well as with endotoxin-induced inflammatory challenges.
CORRESPONDING AUTHOR
A. P. Herman   
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
 
CITATIONS (2):
1. Peripheral Inhibitor of AChE, Neostigmine, Prevents the Inflammatory Dependent Suppression of GnRH/LH Secretion during the Follicular Phase of the Estrous Cycle
Andrzej P. Herman, Janina Skipor, Agata Krawczyńska, Joanna Bochenek, Karolina Wojtulewicz, Hanna Antushevich, Anna Herman, Kamila Paczesna, Katarzyna Romanowicz, Dorota Tomaszewska-Zaremba
BioMed Research International
2. The effect of inflammation on the synthesis of luteinizing hormone and gonadotropin-releasing hormone receptor expression in the pars tuberalis of ewe during different photoperiodic conditions
Karolina Wojtulewicz, Dorota Tomaszewska-Zaremba, Agata Krawczyńska, Monika Tomczyk, Andrzej Przemysław Herman, J. Plaizier
Canadian Journal of Animal Science
ISSN:1230-1388