ORIGINAL PAPER
The effect of repeated endotoxin injections on gonadotropin secretion in ewes
 
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The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
CORRESPONDING AUTHOR
A. P. Herman   

The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
Publication date: 2014-08-20
 
J. Anim. Feed Sci. 2014;23(3):217–221
 
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ABSTRACT
Although it is well known that acute inflammation induced by a single injection of the bacterial endotoxin, lipopolysaccharide (LPS), induces a stress response and suppresses luteinizing hormone (LH) secretion, the effects of repeated endotoxin administration on gonadotropin secretion in sheep have not been studied yet. In this work, the influence of inflammation induced by six days of intravenous LPS injection (400 ng· kg–1 per day) on the release of LH and follicle-stimulating (FSH) hormones was evaluated. Anoestrous ewes were bled twice a day 1 h before and 3 h after LPS injection. Endotoxin injection decreased (P < 0.05) the release of LH from the first day of the experiment. Moreover, on day 5, the suppression of LH secretion was sustained and could also be detected in the samples collected before the next LPS injection. In contrast, elevation (P < 0.05) of FSH release was detected starting from the second dose of the endotoxin. The increased FSH concentration persisted until the end of the experiment. Each LPS injection stimulated (P < 0.05) cortisol release, but from days 3 to 6, this elevation was about three times lower than the level determined during the first two days. The obtained results show that ewes exposed to repeated administration of endotoxin lost their ability to restore proper LH release relatively quickly. This disturbance in gonadotropin secretion could, in part, be associated with the stress induced by LPS, as well as with endotoxin-induced inflammatory challenges.
 
CITATIONS (4):
1.
Peripheral Inhibitor of AChE, Neostigmine, Prevents the Inflammatory Dependent Suppression of GnRH/LH Secretion during the Follicular Phase of the Estrous Cycle
Andrzej P. Herman, Janina Skipor, Agata Krawczyńska, Joanna Bochenek, Karolina Wojtulewicz, Hanna Antushevich, Anna Herman, Kamila Paczesna, Katarzyna Romanowicz, Dorota Tomaszewska-Zaremba
BioMed Research International
 
2.
The effect of inflammation on the synthesis of luteinizing hormone and gonadotropin-releasing hormone receptor expression in the pars tuberalis of ewe during different photoperiodic conditions
Karolina Wojtulewicz, Dorota Tomaszewska-Zaremba, Agata Krawczyńska, Monika Tomczyk, Andrzej Przemysław Herman, J. Plaizier
Canadian Journal of Animal Science
 
3.
Effect of Acute and Prolonged Inflammation on the Gene Expression of Proinflammatory Cytokines and Their Receptors in the Anterior Pituitary Gland of Ewes
Karolina Wojtulewicz, Agata Krawczyńska, Dorota Tomaszewska-Zaremba, Maciej Wójcik, Andrzej Herman
International Journal of Molecular Sciences
 
4.
Anandamide Influences Interleukin-1β Synthesis and IL-1 System Gene Expressions in the Ovine Hypothalamus during Endo-Toxin-Induced Inflammation
Monika Tomczyk, Dorota Tomaszewska-Zaremba, Joanna Bochenek, Anna Herman, Andrzej Herman
Animals
 
ISSN:1230-1388