ORIGINAL PAPER
The effect of exogenous leptin on pancreatic
enzyme secretion in anaesthetized rats
1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences,
05-110 Jabłonna, Poland
2
Department of Veterinary Physiology, School of Veterinary Medicine
Rakuno Gakuen University Ebetsu,
Hokkaido 069-8501, Japan
3
Department of Physiological Sciences, Faculty of Veterinary Medicine,
Warsaw Agricultural University,
02-766 Warsaw, Poland
Publication date: 2005-03-18
Corresponding author
R. Matyjek
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
J. Anim. Feed Sci. 2005;14(2):353-363
KEYWORDS
ABSTRACT
The influence of leptin on the secretion of pancreatic juice was examined in biliary-pancreatic
duct-cannulated anaesthetised rats. Exogenous leptin was given in boluses either intravenously or
intraduodenally. A low dose of leptin (0.1 μg/kg BW) had no effect on pancreatic secretion. Leptin in a
dose of 1 μg/kg BW given intravenously inhibited protein and amylase output only when the exocrine
pancreas was stimulated by CCK-8 (12 pmol/kg BW, iv). Leptin in a high, pharmacological dose (10
μg/kg BW) given intravenously inhibited juice secretion, protein and amylase output, whereas given
intraduodenally, stimulated them. Intravenous infusion of 2-deoxy-glucose (0.25 g/kg BW per h)
induced pancreatic juice secretion, which was abolished by a leptin bolus (10 μg/kg BW). In conclusion,
leptin can regulate the exocrine pancreas via different mechanisms.
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| ISSN: | 1230-1388 |
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