ORIGINAL PAPER
The effect of exogenous leptin on pancreatic enzyme secretion in anaesthetized rats
R. Matyjek 1  
,   J. Woliński 1,   D. Laubitz 1,   S. Kato 2,   R. Zabielski 1, 3
 
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1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
2
Department of Veterinary Physiology, School of Veterinary Medicine Rakuno Gakuen University Ebetsu, Hokkaido 069-8501, Japan
3
Department of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw Agricultural University, 02-766 Warsaw, Poland
CORRESPONDING AUTHOR
R. Matyjek   

The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
Publication date: 2005-03-18
 
J. Anim. Feed Sci. 2005;14(2):353–363
 
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ABSTRACT
The influence of leptin on the secretion of pancreatic juice was examined in biliary-pancreatic duct-cannulated anaesthetised rats. Exogenous leptin was given in boluses either intravenously or intraduodenally. A low dose of leptin (0.1 μg/kg BW) had no effect on pancreatic secretion. Leptin in a dose of 1 μg/kg BW given intravenously inhibited protein and amylase output only when the exocrine pancreas was stimulated by CCK-8 (12 pmol/kg BW, iv). Leptin in a high, pharmacological dose (10 μg/kg BW) given intravenously inhibited juice secretion, protein and amylase output, whereas given intraduodenally, stimulated them. Intravenous infusion of 2-deoxy-glucose (0.25 g/kg BW per h) induced pancreatic juice secretion, which was abolished by a leptin bolus (10 μg/kg BW). In conclusion, leptin can regulate the exocrine pancreas via different mechanisms.
ISSN:1230-1388