ORIGINAL PAPER
Single nucleotide polimorphism database
of candidate genes associated with cow milk protein
biosynthesis
1 |
University of Warmia and Mazury in Olsztyn, Department of Animal Genetics,
Oczapowskiego 5, 10-718 Olsztyn, Poland |
2 |
Institute of Animal Genetics and Breeding, Polish Academy of Sciences,
Jastrzębiec, 05-552 Wólka Kosowska, Poland |
J. Anim. Feed Sci. 2004;13(1):51–64
Publication date: 2004-01-14
KEYWORDS
ABSTRACT
A growing number of mutations within milk protein genes and genes associated milk protein
biosynthesis are not classified and described in ways which facilitate the design and interpretation
of experiments with the use of multiplex PCR or other high throughout screening techniques. The
aim of the study was to process and catalog all available information on single nucleotide polymorphisms (SNPs) located within genes directly, indirectly or potentially associated with bovine milk
protein biosynthesis. All records were divided into 3 groups of polymorphic sequences: milk protein
genes, genes associated with milk protein genes regulation and genes potentially associated with
milk protein biosynthesis.
A database was constructed containing 339 SNPs within 49 genes. Among the 339 SNPs, 316
single nucleotide substitutions, 8 deletions, 5 repeats, 7 indels and 3 insertions were identified. All
collected SNPs were described in such a way as to enable the automatic downloading of GeneBank
records to specialized software and simultaneous design of PCR primers and allele specific probes
used in microarray technology.
It is believed that collection of SNPs presented in this study will serve as a reliable resource for
studies on the genetic determination of milk protein biosynthesis variation and after wide population
screening, also for paternity testing and evolutionary studies in dairy cattle.
CORRESPONDING AUTHOR
S. Kamiński
University of Warmia and Mazury in Olsztyn, Department of Animal Genetics,
Oczapowskiego 5, 10-718 Olsztyn, Poland
CITATIONS (4):
1. |
Simultaneous identification of CSN3 and LGB genotypes in cattle by high-resolution melting curve analysis J. Kyseľová, J. Rychtářová, Z. Sztankóová, V. Czerneková Livestock Science
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2. |
Associations Between Milk Performance Traits in Holstein Cows and 16 Candidate SNPs Identified by Arrayed Primer Extension (APEX) Microarray S. Kamiński, P. Brym, A. Ruść, E. Wójcik, A. Ahman, R. Mägi Animal Biotechnology
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3. |
Towards an integrated approach to study SNPs and expression of candidate genes associated with milk protein biosynthesis S. Kamiński, T. Malewski, A. Ahman, E. Wójcik, A. Ruść, K. Oleński, A. Jakubczak, A. A. Sazanov Russian Journal of Genetics
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4. |
Preliminary Evidence for Association of Prolactin and Prolactin Receptor Genes with Milk Production Traits in Chinese Holsteins Xiucai Hu, Aijun Lü, Hong Chen, Xueyuan Gao, Haixia Xu, Chunlei Zhang, Xingtang Fang, Chuzhao Lei Journal of Applied Animal Research
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