ORIGINAL PAPER
Polymorphism of intronic microsatellites in the
A-FABP and LEPR genes and its association with
productive traits in the pig
1 |
Department of Animal Genetics and Breeding, August Cieszkowski Agricultural University,
Wołyńska 33, Poznań 60-637, Poland |
2 |
Experimental Station,
60-637 Pawłowice, Poland |
3 |
National Research Institute of Animal Production,
32-083 Balice, Poland |
J. Anim. Feed Sci. 2004;13(4):615–624
Publication date: 2004-10-25
KEYWORDS
ABSTRACT
The adipocyte fatty acid-binding protein (A-FABP) and leptin receptor (LEPR) genes are
candidate quantitative trait loci (QTLs) for fatness traits in the pig. In both genes polymorphic short
tandem repeat (STR) sequences in intron 1 (A-FABP) and in intron 3 (LEPR) were revealed. The
association studies between both polymorphisms and productive traits were performed in two breeds
(Polish Large White and Polish Landrace) and one synthetic line (L990) of the pig. In the A-FABP
ten and in the LEPR gene eight alleles were identified, and the polymorphic information content
(PIC) values ranged from 0.713 to 0.749 and from 0.441 to 0.557, respectively. The associations
with backfat thickness and intramuscular fat content were found. Since the observed relationships
considering each gene were not concordant in all the studied populations, it was concluded that both
genes are linked with an unknown QTL.
CORRESPONDING AUTHOR
M. Świtoński
Department of Animal Genetics and Breeding, August Cieszkowski Agricultural University,
Wołyńska 33, Poznań 60-637, Poland
CITATIONS (8):
1. |
Genetic variants of the FABP4 gene are associated with marbling scores and meat quality grades in Hanwoo (Korean cattle) Sung-Chul Shin, Jae-Pil Heo, Eui-Ryong Chung Molecular Biology Reports
|
2. |
Hypothalamic expression of porcine leptin receptor (LEPR), neuropeptide Y (NPY), and cocaine- and amphetamine-regulated transcript (CART) genes is influenced by LEPR genotype Cristina Óvilo, Almudena Fernández, Ana I. Fernández, Josep M. Folch, Luis Varona, Rita Benítez, Yolanda Nuñez, Carmen Rodríguez, Luis Silió Mammalian Genome
|
3. |
A splice site single nucleotide polymorphism of thefatty acid binding protein 4gene appears to be associated with intramuscular fat deposition in longissimus muscle in Australian cattle W. Barendse, R. J. Bunch, M. B. Thomas, B. E. Harrison Animal Genetics
|
4. |
The multigene family of fatty acid-binding proteins (FABPs): Function, structure and polymorphism Agata Chmurzyńska Journal of Applied Genetics
|
5. |
Genetics of fat tissue accumulation in pigs: a comparative approach M. Switonski, M. Stachowiak, J. Cieslak, M. Bartz, M. Grzes Journal of Applied Genetics
|
6. |
Missense mutations in exon 4 of the porcine LEPR gene encoding extracellular domain and their association with fatness traits M. Mackowski, K. Szymoniak, M. Szydlowski, M. Kamyczek, R. Eckert, M. Rozycki, M. Switonski Animal Genetics
|
7. |
Improving the Sensory and Nutritional Quality of Fresh Meat W. Barendse
|
8. |
Genetic Polymorphism of Microsatellite Loci and Their Association with Reproductive Traits in Ukrainian Meat Breed Pigs S. I. Lugovoy, V. R. Kharzinova, S. S. Kramarenko, A. V. Lykhach, A. S. Kramarenko, V. Ya. Lykhach Cytology and Genetics
|