0.857
IF5
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IF
Q3
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0.92
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20
MNiSW
142.18
ICV
REVIEW PAPER
 
CC-BY 4.0
 
 

Perspectives of glutamine and its derivatives as feed additives for farm animals

S. G. Pierzynowski 1, 2,  
A. Sjodin 3, 2
 
1
Department of Animal Physiology, Lund University, Helgonavagen 3 b, SE-223 62 Lund, Sweden
2
Gramineer International AB, Ideon, 223 70 Lund, Sweden
3
Department of Public Health and Caring Sciences, Uppsala University, Box 609, SE-751 25 Uppsala, Sweden
J. Anim. Feed Sci. 1998;7(Suppl. 1):79–91
Publish date: 1998-08-22
KEYWORDS:
ABSTRACT:
Glutamine and its derivatives e.g., alpha-ketoglutaric acid (AKG) or ornithine- alpha-ketoglutarate (OKG) are molecules with a central role (via the Krebs cycle) in systemic, intestinal and gut bacterial metabolism. Studies have shown that AKG is a precursor not only of glutamine and arginine, but also of some other keto acids e.g., alpha-ketoisocaproate which in turn is a precursor of hydroxy-methyl-butyrate, which itself is regarded as a protein catabolic protector. Recently it has been postulated that AKG is not only an important energy donor, but that it also functions as an ammonium ion scavenger via transformation to glutamate, ornithine and putrescine and finally to GABA or succinate. Several beneficial effects of AKG have been reported in human medicine e.g., improved patients' recovery following gastrointestinal surgery. On the other hand, is was reported that 100 per cent glutamate metabolism in the first pass in infant pigs' small intestine. In the current presentation we discuss the potential benefits of using glutamine derivatives in human clinical nutrition as well as their role as feed additives in the production of farm animals.
 
CITATIONS (21):
1. Effects of dietary α-ketoglutarate supplementation on the growth performance, glutamine synthesis and amino acid concentrations of juvenile hybrid sturgeon Acipenser schrenckii ♀×Acipenser baerii ♂ fed high levels of soy protein concentrate
Liansheng Wang, Qiyou Xu, Chang’an Wang, Jinnan Li, Di Chen, Zhigang Zhao, Liang Luo, Xue Du
Animal Feed Science and Technology
2. Intraduodenal infusion of α-ketoglutarate decreases whole body energy expenditure in growing pigs
Peter Junghans, Michael Derno, Stefan Pierzynowski, Ulf Hennig, Paul Eberhard Rudolph, Wolfgang B. Souffrant
Clinical Nutrition
3. Dietary α-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets
Yongqing Hou, Lei Wang, Binying Ding, Yulan Liu, Huiling Zhu, Jian Liu, Yongtang Li, Xin Wu, Yulong Yin, Guoyao Wu
Amino Acids
4. Biology of Nutrition in Growing Animals
S.G. Pierzynowski, D. Kruszewska, B.W. Weström
5. Alpha-Ketoglutarate: Physiological Functions and Applications
Nan Wu, Mingyao Yang, Uma Gaur, Huailiang Xu, Yongfang Yao, Diyan Li
Biomolecules & Therapeutics
6. Anti-osteopenic effect of alpha-ketoglutarate sodium salt in ovariectomized rats
Radoslaw Piotr Radzki, Marek Bienko, Stefan Grzegorz Pierzynowski
Journal of Bone and Mineral Metabolism
7. Growth performance, nitrogen balance, and metabolism of calcium and phosphorus in growing pigs fed diets supplemented with alpha-ketoglutarate
J.S. Chen, F. Wu, H.S. Yang, F.N. Li, Q. Jiang, S.J. Liu, B.J. Kang, S. Li, T.O. Adebowale, N. Huang, H. Li, Y.L. Yin, C.X. Fu, K. Yao
Animal Feed Science and Technology
8. Effects of dietary α-ketoglutarate supplementation on the antioxidant defense system and HSP 70 and HSP 90 gene expression of hybrid sturgeonAcipenser schrenckii ♀ × A. baerii ♂exposed to ammonia-N stress
Liansheng Wang, Qiyou Xu, Chang'an Wang, Jinnan Li, Di Chen, Zhigang Zhao, Liang Luo, Xue Du
Aquaculture Research
9. The glutamine-alpha-ketoglutarate (AKG) metabolism and its nutritional implications
Dingfu Xiao, Liming Zeng, Kang Yao, Xiangfeng Kong, Guoyao Wu, Yulong Yin
Amino Acids
10. Effects of maternal treatment with β-hydroxy-β-metylbutyrate and 2-oxoglutaric acid on femur development in offspring of minks of the standard dark brown type
E. Tomaszewska, P. Dobrowolski, I. Świetlicka, S. Muszyński, K. Kostro, A. Jakubczak, I. Taszkun, A. Żmuda, K. Rycerz, T. Blicharski, J. Jaworska-Adamu
Journal of Animal Physiology and Animal Nutrition
11. Effects of Alpha-Ketoglutarate on Glutamine Metabolism in Piglet Enterocytes in Vivo and in Vitro
Liuqin He, Huan Li, Niu Huang, Junquan Tian, Zhiqiang Liu, Xihong Zhou, Kang Yao, Tiejun Li, Yulong Yin
Journal of Agricultural and Food Chemistry
12. Effect of maternal dexamethasone and alpha-ketoglutarate administration on skeletal development during the last three weeks of prenatal life in pigs
E. Śliwa, M. R. Tatara, H. Nowakowski, S. G. Pierzynowski, T. Studziński
The Journal of Maternal-Fetal & Neonatal Medicine
13. Alpha-ketoglutarate inhibits glutamine degradation and enhances protein synthesis in intestinal porcine epithelial cells
Kang Yao, Yulong Yin, Xilong Li, Pengbin Xi, Junjun Wang, Jian Lei, Yongqing Hou, Guoyao Wu
Amino Acids
14. The protective and therapeutic effect of exclusive and combined treatment with alpha-ketoglutarate sodium salt and ipriflavone on bone loss in orchidectomized rats
R. P. Radzki, M. Bieńko, R. Filip, S. G. Pierzynowski
The journal of nutrition, health & aging
15. Effect of dietary alpha‐ketoglutarate on blood lipid profile during hypercholesterolaemia in rats
Radoslaw P. Radzki, Marek Bieńko, Stefan G. Pierzynowski
Scandinavian Journal of Clinical and Laboratory Investigation
16. Dietary supplementation with glutamate precursor α-ketoglutarate attenuates lipopolysaccharide-induced liver injury in young pigs
Lei Wang, Yongqing Hou, Dan Yi, Yongtang Li, Binying Ding, Huiling Zhu, Jian Liu, Hang Xiao, Guoyao Wu
Amino Acids
17. Maternal treatment with dexamethasone at minimal therapeutic doses inhibits neonatal bone development in a gender-dependent manner
Ewa Tomaszewska, Piotr Dobrowolski, Andrzej Siwicki
Livestock Science
18. Effects of α-ketoglutarate on the growth performance, amino acid metabolism and related gene expression of mirror carp (Cyprinus carpio )
L. Wang, Y. Wei, C. Wang, J. Li, Z. Zhao, L. Luo, X. Du, X. Qiyou
Aquaculture Nutrition
19. Absorption and metabolism of alpha-ketoglutarate in growing pigs
N. B. Kristensen, H. Jungvid, J. A. Fernandez, S. G. Pierzynowski
Journal of Animal Physiology and Animal Nutrition
20. Handbook of nutrition and diet in therapy of bone diseases
M.R. Tatara, W. Krupski, B. Majer-Dziedzic, A. Szabelska
21. The contribution of vacuolated foetal-type enterocytes in the process of maturation of the small intestine in piglets. Invited review
T. Skrzypek, S. Szymańczyk, K. Ferenc, W. Kazimierczak, K. Szczepaniak, R. Zabielski
Journal of Animal and Feed Sciences
ISSN:1230-1388