REVIEW PAPER
Kisspeptin (kiss 1) network signaling of hypothalamic gonadotropin-releasing hormone (GnRH) neurons
 
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1
The Kielanowski Institute of Physiology and Nutrition, Polish Academy of Sciences, Department of Neuroendocrinology, Instytucka 3, 05-110 Jabłonna, Poland
2
The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Department of Pharmacology and Toxicology, Kozielska 4, 01-163 Warsaw, Poland
CORRESPONDING AUTHOR
M. Ciechanowska   

The General Karol Kaczkowski Military Institute of Hygiene and Epidemiology, Department of Pharmacology and Toxicology, Kozielska 4, 01-163 Warsaw, Poland
Publication date: 2012-08-29
 
J. Anim. Feed Sci. 2012;21(3):397–424
 
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ABSTRACT
To regulate reproduction in mammals, internal and external status is communicated to the hypothalamic-pituitary-gonadal axis via a coordinated balance of stimulatory and inhibitory neurochemical systems. This review describes the neuroanatomical organization of the kisspeptin system in the hypothalamus, and summarizes its role in signaling hypothalamic GnRH neurons, namely: multimodal actions of kisspeptin in the control of GnRH secretion during different physiological states of animals; involvement of kisspeptin in relaying metabolic information to hypothalamic GnRH neurons; neurobiological mechanisms underlying kisspeptin activation of GnRH neurons during puberty onset; effect of gonadal steroids in the early postnatal period in rodents on kisspeptin expression in the hypothalamus and gonadotropin secretion in adults; effect of photoperiod and metabolic cues on the activation/inhibition of hypothalamic-pituitary-gonadal axis in seasonally breeding species by kisspeptin.
 
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ISSN:1230-1388