0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
0.405
SJR
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SJR
20
MNiSW
165.24
ICV
REVIEW PAPER
 
CC-BY 4.0
 
 

How does bacterial endotoxin influence gonadoliberin/gonadotropins secretion and action?

A. P. Herman 1,  
 
1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland
J. Anim. Feed Sci. 2016;25(4):283–291
Publish date: 2016-11-25
KEYWORDS:
ABSTRACT:
This review summarizes data concerning the mechanisms by which bacterial endotoxin, lipopolysaccharide (LPS), inhibits gonadoliberin (GnRH)/ luteinizing hormone (LH) secretion in mammals. LPS is a major component of Gram-negative bacteria cell walls and is released from the surface of replicated and dying Gram-negative bacteria into circulation. LPS is commonly used to induce immune/inflammatory challenge in animals. In this article the site of endotoxin action as well as LPS induced mediators are discussed. Hypothalamus seems to be a place where majority of the immune-neuroendocrine interactions occur, however the results of many research suggest that LPS may interfere with reproductive system at the pituitary level as well. Endotoxin may affect GnRH/LH secretion directly via toll-like receptors (TLR)4/TLR2 located both in the hypothalamus and pituitary or indirectly through the intermediates such as cytokines, catecholamines, prostaglandins or opioids.
CORRESPONDING AUTHOR:
D. Tomaszewska-Zaremba   
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland
 
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CITATIONS (4):
1. Peripheral Inhibitor of AChE, Neostigmine, Prevents the Inflammatory Dependent Suppression of GnRH/LH Secretion during the Follicular Phase of the Estrous Cycle
Andrzej P. Herman, Janina Skipor, Agata Krawczyńska, Joanna Bochenek, Karolina Wojtulewicz, Hanna Antushevich, Anna Herman, Kamila Paczesna, Katarzyna Romanowicz, Dorota Tomaszewska-Zaremba
BioMed Research International
2. The effect of inflammation on the synthesis of luteinizing hormone and GnRH receptor expression in the pars tuberalis of ewe during different photoperiodic conditions
Karolina Wojtulewicz, Dorota Tomaszewska-Zaremba, Agata Krawczyńska, Monika Tomczyk, Andrzej Przemysław Herman
Canadian Journal of Animal Science
3. Effect of CD14/TLR4 antagonist on GnRH/LH secretion in ewe during central inflammation induced by intracerebroventricular administration of LPS
Karolina Haziak, Andrzej Przemysław Herman, Karolina Wojtulewicz, Bartosz Pawlina, Kamila Paczesna, Joanna Bochenek, Dorota Tomaszewska-Zaremba
Journal of Animal Science and Biotechnology
4. Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation
Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor
Mediators of Inflammation
ISSN:1230-1388