Effects of dietary caprylic and capric acids on piglet performance and mucosal epithelium structure of the ileum
More details
Hide details
National Research Institute of Animal Production, Department of Animal Nutrition and Feed Science, 32-083 Balice, Poland
Medical College Jagiellonian University, Department of Pathomorphology, Grzegórzecka 16, 31-531 Kraków, Poland
Publication date: 2011-12-06
Corresponding author
E. Hanczakowska   

National Research Institute of Animal Production, Department of Animal Nutrition and Feed Science, 32-083 Balice, Poland
J. Anim. Feed Sci. 2011;20(4):556-565
Effects of a diet supplemented with caprylic and/or capric acid on piglet performance, apparent digestibility of nutrients, intestinal microflora and small intestine (ileum) structure were investigated. The experiment was performed on 252 piglets (24 litters) allocated to 4 experimental groups (6 litters each). The animals were fed with a standard feed mixture (control) or the same mixture supplemented with 2 g of caprylic or capric acid (groups C8 and C10, respectively) per 1 kg of feed. Group C8+C10 received 1 g of caprylic and 1 g of capric acid. Apparent digestibility was estimated using Cr2O3 as an indicator, while microbiological analyses were performed using standard agar plates. The short-chain fatty acid (SCFA) content of the ileum and caecum digesta was analysed using Varian 340 analyzer. The piglets receiving caprylic or capric acids grew significantly (P<0.01) faster than the control ones (average daily gains during the whole experiment, i.e. between days 1 and 84 of age, were: 288, 269, 278 and 234 g, respectively). The best feed utilization (1.3 kg per kg) was found in animals receiving caprylic acid. The acids also lowered piglet mortality, while significantly increased protein digestibility (P<0.01) and, to a lesser degree (P<0.05), also fibre digestibility. There was no significant difference in acidity of the digesta between control and experimental groups. Capric acid increased the amount of aerobic bacteria as compared to the control group, but the amount of Escherichia coli remained unchanged. The population of Clostridium perfringens was reduced by both caprylic and capric acids (P<0.01). Acids had no effect on SCFA content of the ileum but lowered the acetic acid content of the caecum digesta. Capric acid had the strongest effect on villi, which were significantly higher (306 μm) than in the control group (233 μm). Differences in crypt depth were smaller but the crypts were also the deepest in piglets receiving capric acid. The results suggest that caprylic and capric acids added to the feed improve piglet performance, probably due to positive changes in the mucosal epithelium structure of the ileum.
Medium chain fatty acids (MCFA) and/or probiotic Enterococcus faecium as a feed supplement for piglets
E. Hanczakowska, M. Świątkiewicz, M. Natonek-Wiśniewska, K. Okoń
Livestock Science
Effects of dietary combinations of organic acids and medium chain fatty acids as a replacement of zinc oxide on growth, digestibility and immunity of weaned pigs
Y. Kuang, Y. Wang, Y. Zhang, Y. Song, X. Zhang, Y. Lin, L. Che, S. Xu, D. Wu, B. Xue, Z. Fang
Animal Feed Science and Technology
The central role of intestinal health on the effect of feed additives on feed intake in swine and poultry
P.J. van der Aar, F. Molist, J.D. van der Klis
Animal Feed Science and Technology
Function of capric acid in cyclophosphamide-induced intestinal inflammation, oxidative stress, and barrier function in pigs
Sang In Lee, Kyung Soo Kang
Scientific Reports
Short- and medium-chain fatty acids as a feed supplement for weaning and nursery pigs
E. Hanczakowska, A. Szewczyk, M. Świątkiewicz, K. Okoń
Polish Journal of Veterinary Sciences
Applications of new functions for inducing host defense peptides and synergy sterilization of medium chain fatty acids in substituting in-feed antibiotics
Zhongxin Zhou, Jie Huang, Haihong Hao, Hongkui Wei, Yuanfei Zhou, Jian Peng
Journal of Functional Foods
Effect of a protected blend of organic acids and medium-chain fatty acids on growth performance, nutrient digestibility, blood profiles, meat quality, faecal microflora, and faecal gas emission in finishing pigs
D.H. Nguyen, K.Y. Lee, H.N. Tran, I.H. Kim, J. Plaizier
Canadian Journal of Animal Science
Regulatory Functions of Fatty Acids with Different Chain Lengths on the Intestinal Health in Pigs and Relative Signaling Pathways
Jinchao Chen, Yunxia Li, Zhiru Tang, Zhihong Sun
Current Protein & Peptide Science
Effect of dietary supplemental medium chain fatty acids instead of antibiotics on the growth performance, digestibility and blood profiles in growing pigs
Jian Zhang, Dong Baek, In Kim
Journal of Animal Physiology and Animal Nutrition
Efficacy of medium-chain fatty acid salts distilled from coconut oil against two enteric pathogen challenges in weanling piglets
Paola López-Colom, Lorena Castillejos, Agustina Rodríguez-Sorrento, Mónica Puyalto, Juan Mallo, Susana Martín-Orúe
Journal of Animal Science and Biotechnology
Effect of dietary medium-chain fatty acids on nursery pig growth performance, fecal microbial composition, and mitigation properties against porcine epidemic diarrhea virus following storage
Jordan Gebhardt, Katelyn Thomson, Jason Woodworth, Steve Dritz, Michael Tokach, Joel DeRouchey, Robert Goodband, Cassandra Jones, Roger Cochrane, Megan Niederwerder, Samodha Fernando, Waseem Abbas, Thomas Burkey
Journal of Animal Science
From Acidifiers to Intestinal Health Enhancers: How Organic Acids Can Improve Growth Efficiency of Pigs
Tugnoli, Giovagnoni, Piva, Grilli
Impact of in-feed sodium butyrate or sodium heptanoate protected with medium-chain fatty acids on gut health in weaned piglets challenged with Escherichia coli F4+
Paola López-Colom, Lorena Castillejos, Agustina Rodríguez-Sorrento, Mónica Puyalto, Juan Mallo, Susana Martín-Orúe
Archives of Animal Nutrition
Docosahexaenoate-enriched fish oil and medium chain triglycerides shape the feline plasma lipidome and synergistically decrease circulating gut microbiome-derived putrefactive postbiotics
Matthew Jackson, Dennis Jewell, Catherine Mounier
Evaluation of different blends of medium-chain fatty acids, lactic acid, and monolaurin on nursery pig growth performance1,2
Lori Thomas, Jason Woodworth, Mike Tokach, Steve Dritz, Joel DeRouchey, Robert Goodband, Hayden Williams, Ashley Hartman, Dillon Mellick, Denny McKilligan, Aaron Jones
Translational Animal Science
Medium-chain fatty acids and monoglycerides as feed additives for pig production: towards gut health improvement and feed pathogen mitigation
Joshua Jackman, R. Boyd, Charles Elrod
Journal of Animal Science and Biotechnology
Effect of Maternal Diet and Medium Chain Fatty Acids Supplementation for Piglets on Their Digestive Tract Development, Structure, and Chyme Acidity as Well as Performance and Health Status
Małgorzata Świątkiewicz, Ewa Hanczakowska, Krzysztof Okoń, Piotr Kowalczyk, Eugeniusz Grela
Protected Organic Acids Improved Growth Performance, Nutrient Digestibility, and Decreased Gas Emission in Broilers
Dinh Nguyen, In Kim
Towards Zero Zinc Oxide: Feeding Strategies to Manage Post-Weaning Diarrhea in Piglets
Andrea Bonetti, Benedetta Tugnoli, Andrea Piva, Ester Grilli
The Impact of Weaning Stress on Gut Health and the Mechanistic Aspects of Several Feed Additives Contributing to Improved Gut Health Function in Weanling Piglets—A Review
Santi-Devi Upadhaya, In-Ho Kim
Effects of the supplementation of a calcium soap containing medium‐chain fatty acids on the fecal microbiota of pigs, lactating cows, and calves
Hiroki Matsui, Taichi Imai, Makoto Kondo, Tomomi Ban‐Tokuda, Yutaka Yamada
Animal Science Journal
Effect of dietary supplementation of lauric acid on growth performance, antioxidative capacity, intestinal development and gut microbiota on black sea bream (Acanthopagrus schlegelii)
Sami Ullah, Jinzhi Zhang, Bingying Xu, Arnaud Tegomo, Gladstone Sagada, Lu Zheng, Lei Wang, Qingjun Shao, Mahmoud Dawood
Comparison of medium chain organic acids with zinc oxide and benzoic acid; effect on growth performance of pigs
N. Portocarero
Journal of Applied Animal Nutrition
Application of metabolomics to assess the intestinal response to dietary supplementation
Shima Borzouie, Bruce Rathgeber, Leslie MacLaren
CABI Reviews
A blend of medium-chain fatty acids, butyrate, organic acids, and a phenolic compound accelerates microbial maturation in newly weaned piglets
Natalie Diether, Tetske Hulshof, Benjamin Willing, Kempen van, Ewa Tomaszewska
Regulation of survival, growth performance, and intestinal health of large yellow croaker (Larimichthys crocea) larvae by sodium decanoate supplementation
Yongtao Liu, Yuntao Wang, Jianmin Zhang, Zhen Wang, Shijie Pan, Zhihao Zhang, Qiuxin Yan, Yucong Hong, Yueru Li, Kangsen Mai, Qinghui Ai
Feeding of fish oil and medium-chain triglycerides to canines impacts circulating structural and energetic lipids, endocannabinoids, and non-lipid metabolite profiles
Matthew Jackson, Dennis Jewell
Frontiers in Veterinary Science
Role of sodium octanoate in regulating survival, growth, intestinal development, digestive and absorptive capacities, antioxidant capacity and innate immunity of large yellow croaker (Larimichthys crocea) larvae
Yongtao Liu, Yucong Hong, Chuanwei Yao, Chenxiang Zhang, Zengqi Zhao, Wencong Zhang, Wencong Lai, Jinze Zhang, Yueru Li, Kangsen Mai, Qinghui Ai
CPX-351 exploits the gut microbiota to promote mucosal barrier function, colonization resistance, and immune homeostasis
Giorgia Renga, Emilia Nunzi, Claudia Stincardini, Marilena Pariano, Matteo Puccetti, Giuseppe Pieraccini, Claudia Di Serio, Maurizio Fraziano, Noemi Poerio, Vasileios Oikonomou, Paolo Mosci, Enrico Garaci, Luana Fianchi, Livio Pagano, Luigina Romani
Dietary monoglyceride supplementation to support intestinal integrity and host defenses in health-challenged weanling pigs
Cameron S White, Chien-Che Hung, Saraswathi Lanka, Carol W Maddox, Adriana Barri, Adebayo O Sokale, Ryan N Dilger
Journal of Animal Science
Journals System - logo
Scroll to top