ORIGINAL PAPER
 
KEYWORDS
TOPICS
ABSTRACT
Selenium is an essential trace element for pig growth; generally, inorganic or organic selenium is used for dietary selenium supplementation. Newborn piglets obtain all nutrients from the sow; thus, the sow absorption rate of different selenium sources significantly affects sow reproductive performance and piglet development. Therefore, a meta-analysis was performed to provide insights into whether organic selenium is better than mineral selenium for improving sow reproductive performance and piglet development. The present study investigated the effects of different selenium sources in sow feed using articles published between June 1, 1980, and December 31, 2020, from four databases. In the meta-analysis, 19 articles (347 sows) from seven countries were included. It was shown that feeding organic selenium to sows during pregnancy significantly increased newborn piglet weight (P < 0.05), piglet weight at weaning (P < 0.05), litter weight at weaning (P < 0.01), selenium content in sow colostrum (P < 0.01), milk (P < 0.01) and serum (P < 0.01); and selenium content (P < 0.01) and glutathione peroxidase activity (P < 0.05) in piglet serum. However, it had no effect on the number of live-born piglets and litter weight at birth. Owing to study heterogeneity (I2 > 50%), we hypothesized that the sow breed or weaning age were the influencing factors. Publication bias and sensitivity analyses indicate that the present results are robust. Further research is needed to better understand how different selenium sources affect sow reproduction and piglet development.
FUNDING
A project was funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
CONFLICT OF INTEREST
The authors declare that there is no conflict of interest.
 
REFERENCES (53)
1.
Belyaev V.I., Mel’nikova T.E., Shushchlebin V.I., 2006. Biochemical characteristics of blood in pregnant sows and their progeny under the influence of selekor. S-kh. Biol. 2, 93–94.
 
2.
Boryaev G., Fedorov Y., Nevitov M., 2005. About an effect of selenium preparation on immune system of young pigs. Agric. Biol. 4, 64–68.
 
3.
Chen Z., Ye S., Teng J., Diao S., Yuan X., Chen Z., Zhang H., Li J., Zhang Z., 2019. Genome-wide association studies for the number of animals born alive and dead in duroc pigs. Theriogenology 139, 36–42, https://doi.org/10.1016/j.ther....
 
4.
Dalgaard T.S., Briens M., Engberg R.M., Lauridsen C., 2018. The influence of selenium and selenoproteins on immune responses of poultry and pigs. Anim. Feed Sci. Technol. 238, 73–83, https://doi.org/10.1016/j.anif....
 
5.
Duntas L.H., Benvenga S., 2015. Selenium: an element for life. Endocrine 48, 756–775, https://doi.org/10.1007/s12020....
 
6.
Egger M., Smith G.D., Schneider M., Minder C., 1997. Bias in meta-analysis detected by a simple, graphical test. Br. Med. J. 315, 629–634, https://doi.org/10.1136/bmj.31....
 
7.
Falk M., Bernhoft A., Reinoso-Maset E., Salbu B., Lebed P., Framstad T., Fuhrmann H., Oropeza-Moe M., 2020. Beneficial antioxidant status of piglets from sows fed selenomethionine compared with piglets from sows fed sodium selenite. J. Trace Elem. Med. Biol. 58, 126439, https://doi.org/10.1016/j.jtem....
 
8.
Falk M., Lebed P., Bernhoft A., Framstad T., Kristoffersen A.B., Salbu B., Oropeza-Moe M., 2019. Effects of sodium selenite and L-selenomethionine on feed intake, clinically relevant blood parameters and selenium species in plasma, colostrum and milk from high-yielding sows. J. Trace Elem. Med. Biol. 52, 176-185, https://doi.org/10.1016/j.jtem....
 
9.
Fontaine M., Valli V.E., Young L.G., Lumsden J.H., 1977. Studies on vitamin E and selenium deficiency in young pigs. I. Hematological and biochemical changes. Can. J. Comp. Med. 41, 41–51.
 
10.
Gurevitch J., Koricheva J., Nakagawa S., Stewart G., 2018. Meta-analysis and the science of research synthesis. Nature 555, 175–182, https://doi.org/10.1038/nature....
 
11.
Hostetler C.E., Kincaid R.L., 2004. Gestational changes in concentrations of selenium and zinc in the porcine fetus and the effects of maternal intake of selenium. Biol. Trace Elem. Res. 97, 57–70, https://doi.org/10.1385/BTER:9....
 
12.
Higgins J.P.T., Thompson S.G., 2002. Quatifying heterogeneity in a meta-analysis. Stat. Med. 21, 1539–1558, https://doi.org/10.1002/sim.11....
 
13.
Higgins J.P.T., Green S. (Editors). 2005. Cochrane Handbook for Systematic Reviews of Interventions version 4.2.5. John Wiley & Sons. Chichester (UK).
 
14.
Hooijmans C.R., Rovers M.M., de Vries R.B.M., Leenaars M., Ritskes-Hoitinga M., Langendam M.W., 2014. SYRCLE’s risk of bias tool for animal studies. BMC Med. Res. Methodol. 14, 43, https://doi.org/10.1186/1471-2....
 
15.
Huedo-Medina T.B., Sánchez-Meca J., Marín-Martínez F., Botella J., 2006. Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol. Method. 11, 193–206, https://doi.org/10.1037/1082-9....
 
16.
Jia J.Y., 2007. Effect of different source selenium on piglets of sows tissue selenium deposition and blood biochemical parameters. MSc Thesis. Sichuan Agriculture University. Ya’an, Sichuan (China).
 
17.
Kim Y.Y., Mahan D.C., 2001. Prolonged feeding of high dietary levels of organic and inorganic selenium to gilts from 25 kg body weight through one parity. J. Anim. Sci. 79, 956–966, https://doi.org/10.2527/2001.7....
 
18.
Lampe J., Gourley G., Sparks J., Stumpf T., 2005. Prewean piglet survivability: Sel-Plex verses sodium selenite as selenium source in sow diets. J. Anim. Sci. 83, Suppl. 2, 51 (abstract 205).
 
19.
Li N.Y., Sun Z.J., Ansari A.R. et al., 2020. Impact of maternal selenium supplementation from late gestation and lactation on piglet immune function. Biol. Trace Elem. Res. 194, 159–167, https://doi.org/10.1007/s12011....
 
20.
Li X., 2009. Effect of sows supplement different selenium sources on growth performance of nursing pigs and approaching to its mechanism. MSc Thesis. Zhejiang University. Zhejiang (China).
 
21.
Lin C.G., Lin J.Y., Lin Z.Y., Liu Y.X., Zheng J.G., 2013. Effects of different selenium sources on the performance of sows during lactation and the selenium content in plasma and milk. Chin. J. Anim. Husb. 2013(21), 48–52, https://kns.cnki.net/kcms/deta....
 
22.
Ma Y.L., Lindemann M.D., Pierce J.L., Unrine J.M., Cromwell G.L., 2014. Effect of inorganic or organic selenium supplementation on reproductive performance and tissue trace mineral concentrations in gravid first-parity gilts, fetuses, and nursing piglets. J. Anim. Sci. 92, 5540–5550, https://doi.org/10.2527/jas.20....
 
23.
Mahan D.C., 2000. Effect of organic and inorganic selenium sources and levels on sow colostrum and milk selenium content. J. Anim. Sci. 78, 100–105, https://doi.org/10.2527/2000.7....
 
24.
Mahan D.C., Kim Y.Y., 1996. Effect of inorganic or organic selenium at two dietary levels on reproductive performance and tissue selenium concentrations in first-parity gilts and their progeny. J. Anim. Sci. 74, 2711–2718, https://doi.org/10.2527/1996.7....
 
25.
Mahan D.C., Penhale L.H., Cline J.H., Moxon A.L., Fetter A.W., Yarrington J.T., 1974. Efficacy of supplemental selenium in reproductive diets on sow and progeny performance. J. Anim. Sci. 39, 536–543, https://doi.org/10.2527/jas197....
 
26.
Mahan D.C, Peters J.C., 2004. Long-term effects of dietary organic and inorganic selenium sources and levels on reproducing sows and their progeny. J. Anim. Sci. 82, 1343–1358, https://doi.org/10.2527/2004.8....
 
27.
Mahan D.C., Peters J.C., Hill G.M., 2007. Are antioxidants associated with pig and sow mortalities? In: Swine Nutrition Conference Proceedings. Indianapolis, IN (USA), pp. 13–21.
 
28.
Mahmoud K.Z., Edens F.W., 2005. Influence of organic selenium on hsp70 response of heat-stressed and enteropathogenic Escherichia coli-challenged broiler chickens (Gallus gallus). Comp. Biochem. Physiol. Part C Toxicol. Pharmacol. 141, 69–75, https://doi.org/10.1016/j.cca.....
 
29.
Mehdi Y., Hornick J.-L., Istasse L., Dufrasne I., 2013. Selenium in the environment, metabolism and involvement in body functions. Molecules 18, 3292–3311, https://doi.org/10.3390/molecu....
 
30.
Mou D., Ding D., Li S. et al., 2020a. Effect of maternal organic selenium supplementation during pregnancy on sow reproductive performance and long-term effect on their progeny. J. Anim. Sci., 98, skaa366, https://doi.org/10.1093/jas/sk....
 
31.
Mou D., Ding D., Yan H. et al., 2020b. Maternal supplementation of organic selenium during gestation improves sows and offspring antioxidant capacity and inflammatory status and promotes embryo survival. Food Funct. 11, 7748–7761, https://doi.org/10.1039/D0FO00....
 
32.
Oikawa-Takada N., Oshida T., Dohgasaki C., Sakurai M., 2005. Changes of the selenium content in whole blood and milk from brood sows and piglets. Jpn. J. Swine Sci. 42(3), 121–129, https://doi.org/10.5938/youton....
 
33.
Oropeza-Moe M., Wisløff H., Bernhoft A., 2015. Selenium deficiency associated porcine and human cardiomyopathies. J. Trace Elem. Med. Biol. 31, 148–156, https://doi.org/10.1016/j.jtem....
 
34.
Park M., Lee S.H., Pak Y.N., 2015. Analysis of selenoaminoacids and selenoproteins in blood serum of sows fed by selenium fortified feed. Anal. Sci. Technol. 28, 196–203, https://doi.org/10.5806/AST.20....
 
35.
Quesnel H., Renaudin A., Le Floc’h N., Jondreville C., Père M.C., Taylor-Pickard J.A., Le Dividich J., 2008. Effect of organic and inorganic selenium sources in sow diets on colostrum production and piglet response to a poor sanitary environment after weaning. Animal 2, 859–866, https://doi.org/10.1017/S17517....
 
36.
Rafai P., Jakab L., 1999. The effect of feed supplementation with organically bound selenium on reproductive performance of gilts and multiparous sows. Magyar Allatorvosok Lapja 121, 610–615.
 
37.
Stewart L.A., Clarke M., Rovers M., Riley R.D., Simmonds M., Steward G., Tierney J.F., PRISMA-IPD Development Group, 2015. Preferred reporting items for a systematic review and meta-analyses of individual participant data: the PRISMA-IPD Statement. JAMA 313, 1657–1665, https://doi.org/10.1001/jama.2....
 
38.
Surai P.F., 2006. Selenium in Nutrition and Health. University of Nottingham. Nottingham (UK).
 
39.
Surai P.F., Fisinin V.I., 2014. Selenium in poultry breeder nutrition: an update. Anim. Feed Sci. Technol. 191, 1–15, https://doi.org/10.1016/j.anif....
 
40.
Surai P.F., Fisinin V.I., 2016. Selenium in sow nutrition. Anim. Feed Sci. Technol. 211, 18–30, https://doi.org/10.1016/j.anif....
 
41.
Svoboda M., Ficek R., Drábek J., 2008. Efficacy of organic selenium from Se-enriched yeast on selenium transfer from sows to piglets. Acta Vet. Brno 77, 515–521, https://doi.org/10.2754/avb200....
 
42.
Svoboda M., Kotrbáček V. Ficek R., Drábek J., 2009. Effect of organic selenium from Se-enriched alga (Chlorella spp.) on selenium transfer from sows to their progeny. Acta Vet. Brno 78, 373–377, https://doi.org/10.2754/avb200....
 
43.
Szuba-Trznadel A., Hikawczuk T., Ciura A., Fuchs B., 2017. Effect of organic and mineral selenium sources on production performance and selected physiological indicators in swine. Med. Wet. 73, 756–763, https://doi.org/10.21521/mw.58....
 
44.
Steichen T.J., 2000. sbe39: Nonparametric trim and fill analysis of publication bias in meta-analysis. Stata Tech. Bull. 57, 8–14. Reprinted in Stata Tech. Bull. Reprints 10, 108–117. Stata Press. College Station, TX (USA).
 
45.
Wang H., Chan Y.L., Li T.L. et al., 2013. Reduction of splenic immunosuppressive cells and enhancement of anti-tumor immunity by synergy of fish oil and selenium yeast. PLOS ONE 8, e52912, https://doi.org/10.1371/journa....
 
46.
Wang X., Zuo Z., Deng J. et al., 2018. Protective role of selenium in immune-relevant cytokine and immunoglobulin production by piglet splenic lymphocytes exposed to deoxynivalenol. Biol. Trace Elem. Res. 184, 83–91, https://doi.org/10.1007/s12011....
 
47.
Wang Y.P., Yang P.B., 2013. Effect of selenium yeast, inorganic selenium on the reproduction performance of sows and the selenium in deposition in tissues of piglet. Chin. Anim. Husb. Vet. Med. 40, 161–164.
 
48.
Wisdom S.J., Wilson R., McKillop J.H., Walker J.J., 1991. Antioxidant systems in normal pregnancy and in pregnancy-inducted hypertension. Am. J. Obstet. Gynecol. 165, 1701–1704, https://doi.org/10.1016/0002-9....
 
49.
Xu G.X., Lu L.Z., Duan S.X., Chen T., Yu D.L., 2017. Effect of different levels of selenium source on growth performance, reproductive performance and hematological indexes of pregnancy sows. Feed Ind. 2017(12), 16–20, https://doi.org/10.13302/j.cnk....
 
50.
Yoon I., McMillan E., 2006. Comparative effects of organic and inorganic selenium on selenium transfer from sows to nursing pigs. J. Anim. Sci. 84, 1729–1733, https://doi.org/10.2527/jas.20....
 
51.
Yue Z.H., 2012. Effects of selenium from different sources on reproductive performance of sows. Chin. Swine Ind. 2012(12), 49–51, https://doi.org/10.16174/j.cnk....
 
52.
Zhao Y., Flowers W.L., Saraiva A., Yeum K.J., Kim S.W., 2013. Effect of social ranks and gestation housing systems on oxidative stress status, reproductive performance, and immune status of sows. J. Anim. Sci. 91, 5848–5858, https://doi.org/10.2527/jas.20....
 
53.
Zheng J.J., 2006. Effect of feed yeast and selenium yeast on sow reproductive performance and piglet performance. MSc Thesis. Sichuan Agriculture University. Ya’an, Sichuan (China).
 
 
CITATIONS (5):
1.
Nano-selenium and Macleaya cordata Extracts Improved Immune Function and Reduced Oxidative Damage of Sows and IUGR Piglets After Heat Stress of Sows in Late Gestation
Yuanfeng Li, Mingdong Fan, Quanyou Qiu, Yachao Wang, Xiaoyun Shen, Kui Zhao
Biological Trace Element Research
 
2.
Evaluation of selenium source on nursery pig growth performance, serum and tissue selenium concentrations, and serum antioxidant status
Zhong-Xing Rao, Mike Tokach, Jason Woodworth, Joel DeRouchey, Robert Goodband, Jordan Gebhardt
Translational Animal Science
 
3.
Selenium Injection in Dam Rabbits During Gestation Has Important Effects on Progeny Productive Performance
Alejandra García-Medina, Luis Becerril-Martínez, G. Parra-Bracamonte, Fernando Sánchez-Dávila, Benito Albarrán-Portillo, Chris Andrews, Nicolás López-Villalobos, Julio Gómez-Vargas, José Vázquez-Armijo
Biological Trace Element Research
 
4.
Organic selenium and vitamin E for gilts and sows bred in equatorial climate
Tiago Andrade, Pedro Watanabe, Mendonça de, Eloisa Vieira, Alcântara de, Deborah Vasconcelos, Bruno Urach, Bruno Silva, Ednardo Freitas
Journal of Animal Physiology and Animal Nutrition
 
5.
Organic selenium and tocopherol supplementation for multiparous sows without adiabatic cooling: Effects on performance, milk composition, and serum antioxidant enzymes
Tiago Silva Andrade, Pedro Henrique Watanabe, Ingrid Barbosa de Mendonça, Eloisa Helena Mendes Vieira, Gabriel Gobira de Alcântara Araújo, Deborah Marrocos Sampaio Vasconcelos, Bruno Alexander Nunes Silva, Ednardo Rodrigues Freitas
Animal Feed Science and Technology
 
ISSN:1230-1388
Journals System - logo
Scroll to top