Effect of iron supplementation on intestinal function and oxidative stress in piglets with induced colitis
Q. Chen 1,2
X. Jin 2
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Key Laboratory of Food Science and Safety, Ministry of Education, Southern Yangtze University, Wuxi 214036, P.R. China
Institute of Animal Science, Jilin Academy of Agricultural Science, Gongzhuling 136100, P.R. China
Publication date: 2007-05-02
Corresponding author
G. W. Le   

Key Laboratory of Food Science and Safety, Ministry of Education, Southern Yangtze University, Wuxi 214036, P.R. China
J. Anim. Feed Sci. 2007;16(2):205-213
To estimate the effect of oral iron on the intestinal function and oxidative redox status in piglets with dextran sulphate sodium (DSS)-induced colitis, fifty 21-day-old weaned piglets were randomly divided into five groups of ten each. The piglets received regular diet and water, or four diets with 0, 0.03, 0.2 or 1% FeSO4·2H2O and water with 4% DSS, respectively, for 10 days. We observed a markedly higher lactulose/mannitol (Lac/Man) excretion ratio and lower serum concentration of D-xylose in Fe 0.2 and 1% supplementated piglets than piglets on DSS alone, but not in Fe 0.03% supplemented piglets. The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) significantly increased in the DSS group compared with the control group. Iron supplementation significantly decreased the activities of GPx and CAT, as was vitamin E content, but not SOD. Furthermore, excess iron significantly increased the production of malondialdehyde (MDA) and hydroperoxides (HP), in a dose-response related manner.
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