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ORIGINAL PAPER
 
CC-BY 4.0
 
 

The effects of cowpea (Vigna unguiculata) feeding on basal, exogenous cholecystokinin (CCK33) and secretin stimulated pancreatic secretions of the anaesthetized rat

E. Umapathy 2,  
C. Musara 1,  
E. Kandiwa 1,  
D. Kruszewska 3, 4, 5,  
I. Mattsson 6,  
 
1
University of Zimbabwe, Faculty of Veterinary Science, Box MP 167, Mt Pleasant Harare, Zimbabwe
2
Department of Physiology, Faculty of Health Sciences, University of Transkei, P. Bag X01, Umtata, 5117 Eastern Cape Province, South Africa
3
Department of Medical Microbiology, Dermatology Infection, Lund University, Sölvegaten 23, S-223 62 Lund, Sweden
4
Institute of Ecology, Polish Academy of Sciences, Dziekanów Leśny, 05-092 Łomianki, Poland
5
Department of Pharmaceutical Microbiology, Medical University of Warsaw, 02-007 Warszawa, Oczki 3, Poland
6
Department of Animal Physiology, Lund University, Helgonawägen 3b, SE-223 62 Lund, Sweden
7
R&D, Gramineer Int. AB, Ideon beta, SE-223 70 Lund, Sweden
J. Anim. Feed Sci. 2001;10(3):525–534
Publish date: 2001-08-07
KEYWORDS
ABSTRACT
To study the effects of chronic feeding of cowpea (Vigna unguiculata) on the exocrine pancreatic secretions of the rat, 32 four-week old rats were randomly assigned to four dietary groups: I. ad libitum standard rat feed (controls), II. raw cowpea ad libitum, III. cooked (boiled cowpea) ad libitum, and IV. restricted access to standard rat feed. The pancreatic duct was catheterized for total collection of pancreatic juice. After 12 weeks of dietary treatments the rats kept on cowpea diet and restrictively fed rats exhibited reduced growth and feed consumption compared to the controls. Diet had no significant effect on the volume of pancreatic juice and total protein output under basal conditions. Trypsin activity outflow in basal and stimulated conditions showed a tendency to be higher in rats fed a restricted diet and cooked cowpea diet as compared to the rats fed a standard diet and raw cowpea diet. Intra-venous CCK33 and secretin significantly increased the volume and pancreatic juice protein output in all the groups. However, potency of the stimulation for volume and pancreatic protein outputs were higher in rats fed standard diet compared to the other groups. Dietary cowpea enhanced basal as well as stimulated pancreatic secretion (volume, protein and trypsin outputs) in a manner similar to that observed in the rats fed restricted diet.
CORRESPONDING AUTHOR
K. H. Erlwanger
University of Zimbabwe, Faculty of Veterinary Science, Box MP 167, Mt Pleasant Harare, Zimbabwe
 
CITATIONS (1):
1. The Effects of Dietary Raw and Heat-Treated Cowpea (Vigna unguiculata) on Growth and Intestinal Histomorphometry of Pigs
Ekambaram Umapathy ., Kennedy H. Erlwanger .
Journal of Biological Sciences
ISSN:1230-1388