REVIEW PAPER
Relations between pig growth and regulatory
mechanism of pancreas - facts and hypotheses
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Department of Cell and Organism Biology, Lund University,
Helgonavägen 3b, 223 62 Lund, Sweden
Publication date: 2005-06-21
Corresponding author
S. G. Pierzynowski
Department of Cell and Organism Biology, Lund University,
Helgonavägen 3b, 223 62 Lund, Sweden
J. Anim. Feed Sci. 2005;14(Suppl. 1):139-144
KEYWORDS
ABSTRACT
The aim of the mini review is to more precisely determine the relationship between exocrine
pancreas function and the growth of young pigs. In order to do so, it is necessary to clarify the
components, pathways and messengers involved in the CCK-dependent neuro-hormonal regulation
of the exocrine pancreas in the growing pigs. These mechanisms are largely unknown, and the
role of CCK has been questioned since CCK receptors on the enzyme producing acinar cells are
lacking. Our hitherto obtained results have shown the importance of CCK for the pancreatic enzyme
secretion and that in pigs CCK functions via CCK-B receptor-mediated entero(duodenal)-pancreatic
reflex and via CCK-A receptor mechanism which localization is unknown. Preliminary studies have
indicated this later mechanism as being related to the growth performance of pigs. The planned
studies will comprise a pharmacologic characterization and an immunohistologic localization of the
components and messengers involved in the CCK-dependent neuro-hormonal pancreatic regulation
using an appropriately catheterized pig model. Since the applied aim of the project is to correlate
the growth of the pigs to the effectiveness of the pancreatic secretion and to the development of its
regulatory mechanisms, the experiments will be performed on pigs having different growth and
performance.
It is expected that the discussion will provide important applicable understanding of pancreatic
function and its impact on pig growth and performance and also highlight the mechanism of the
inter-organ regulatory pathways of the exocrine pancreatic function.
CITATIONS (1):
1.
Pancreas—Its Functions, Disorders, and Physiological Impact on the Mammals’ Organism
Monika Karpińska, Marian Czauderna
Frontiers in Physiology