ORIGINAL PAPER
Myoinositol augments insulin release from perfused rat pancreas
 
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Department of Animal Physiology and Biochemistry, Agriculture University, Wołyńska 35, 60-637 Poznań, Poland
Publication date: 1999-01-02
 
J. Anim. Feed Sci. 1999;8(1):107–113
 
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ABSTRACT
To test the direct influence of myoinositol on insulin release, rat pancreases were perfused with a medium containing glucose (6.6 mmol/L) or glucose with myoinositol at concentrations of 0.15, 1.55 or 15.5 mmol/L. Myoinositol at the lowest concentration was without effect. At concentrations of 1.55 and 15.5 mmol/L inositol significantly augmented insulin secretion; the total amount of insulin released during perfusions (30 min) with this compound was 508 and 478 µU, respectively vs 353 µU secreted during the same time of perfusion without inositol. It seems quite possible that inositol may augment insulin secretion by formation of ATP, inositol phospholipids or inositol hexaphosphate.
 
CITATIONS (2):
1.
Lack of effects of myo-inositol on metabolism of primary rat adipocytes
Tomasz Szkudelski, Iwona Hertig, Katarzyna Szkudelska
Archives of Physiology and Biochemistry
 
2.
The Effect of Myo-Inositol on Ethanol-Induced Metabolic Changes and Insulin Concentration in the Rat
T. Szkudelski, K. Kandulska
Archives of Physiology and Biochemistry
 
ISSN:1230-1388