0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
0.405
SJR
Q2
SJR
20
MNiSW
165.24
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

Protein turnover, body composition, muscle characteristics, and blood hormones in response to different direction of growth selection in mice

R. Schadereit 1,  
Ch. Rehfeldt 1,  
M. Klein 1,  
E. Kanitz 1,  
 
1
Research Institute for the Biology of Farm Animals, Department of Nutritional Physiology „ Oskar Kellner", 18059 Rostock, Germany
2
Institute for Applied Agricultural Ecology, University of Rostock, Justus-von-Liebig-Weg 2, 18059 Rostock, Germany
J. Anim. Feed Sci. 1998;7(3):333–352
Publish date: 1998-06-24
Supplementary files
KEYWORDS
ABSTRACT
Whole body protein turnover and tissue traits were studied in growing male mice long-term selected (78 generations) for carcass protein mass (DU-6P, protein line), for body weight (DU-6, growth line) or for an index combining body weight and treadmill performance (DU-6+LB, growth+fitness line) and in the unselected randomly bred control (DU-Ks). For the estimation of protein turnover data six mice of each line were housed individually in metabolic cages and were fed ad libitum a commercial stock diet (crude protein 268 g, gross energy 19 MJ/kg DM). At the end of the experiment body weight of all selected mice was about twice that of the controls. Fractional rates of protein synthesis (scaled to the corresponding body protein pools) were significantly higher in selected mice than in controls, but were not significantly different between the protein and growth line in contrast to the protein deposition rates. Chemical body composition was changed in dependence on selection traits. In the growth line body fat content was highest at the expense of protein content; in the protein line the proportion of lean body mass (muscle protein) was highest. This is supported by results of a previous experiment (generation 68) on 60-days old mice showing an enlargement of cross sectional area of the EDL muscle. The number of capillaries per fibre as indicator for nutrient and oxygen supply of the muscle w as adequately increased with the enlargement of muscle cross section in all selection lines, but it was even doubled in the growth+fitness line. No significant alterations in blood thyroid hormone levels (T3, T4 ) or in free glutamine content of muscles extracts were observed in response to selection. Plasma IGF-I levels were higher in selected lines than in controls.
 
CITATIONS (6):
1. Phenotypic characterisation of extreme growth-selected mouse lines: An important prerequisite for future QTL analysis
Ulla Renne, Gerhard Dietl, Martina Langhammer, Charlotte Rehfeldt, Karin Nürnberg, Siegfried Kuhla, Lutz Bünger
Open Life Sciences
2. Estimation of Nitrogen Maintenance Requirements and Potential for Nitrogen Deposition in Fast-Growing Chickens Depending on Age and Sex
Poultry Science
3. Myogenesis and postnatal skeletal muscle cell growth as influenced by selection
C. Rehfeldt, I. Fiedler, G. Dietl, K. Ender
Livestock Production Science
4. La sélection sur la croissance de la truite fario (Salmo trutta) affecte la consommation mais pas l'efficacité alimentaire.
M Sanchez
Aquatic Living Resources
5. Effects of the Compact Mutant Myostatin Allele Mstn Cmpt-dl1Abc Introgressed into a High Growth Mouse Line on Skeletal Muscle Cellularity
Charlotte Rehfeldt, Gerhard Ott, David E. Gerrard, László Varga, Werner Schlote, John L. Williams, Ulla Renne, Lutz Bünger
Journal of Muscle Research and Cell Motility
6. Enhanced sensitivity of skeletal muscle growth in offspring of mice long-term selected for high body mass in response to a maternal high-protein/low-carbohydrate diet during lactation
Charlotte Rehfeldt, Martina Langhammer, Marzena Kucia, Gerd Nürnberg, Cornelia C. Metges
European Journal of Nutrition
ISSN:1230-1388