Proliferation and apoptosis in the rabbit ovary after administration of T-2 toxin and quercetin
More details
Hide details
University of Agriculture in Krakow, Department of Animal Physiology and Endocrinology, Al. Mickiewicza 24/28, 30-059 Kraków, Poland
Slovak University of Agriculture in Nitra, Department of Animal Physiology, Tr. A. Hlinku 2,949 76 Nitra, Slovak Republic
Institute of Genetics and Reproduction of Farm Animals, Animal Production Research Centre Nitra, Hlohovecka 2, 949 92 Lužianky, Slovak Republic
A. Hrabia   

University of Agriculture in Krakow, Department of Animal Physiology and Endocrinology, Al. Mickiewicza 24/28, 30-059 Kraków, Poland
Publication date: 2013-09-02
J. Anim. Feed Sci. 2013;22(3):264–271
T-2 mycotoxin, a natural contaminant of cereals and agricultural products, is known to exhibit the severest toxicity and the lowest LD50 value among trichothecenes. Since quercetin has been reported to have strong antioxidant properties, the effect of quercetin and T-2 toxin on rabbit ovarian cell proliferation and apoptosis was assessed. In the ovaries, proliferating cells were analysed immunocytochemically (proliferating cell nuclear antigen as a marker) and apoptotic cells by the terminal deoxynucleotidyl transferase (TdT)-mediated biotinylated deoxyuridine triphosphates (dUTP) nick endlabeling (TUNEL) method. It was found that: 1. a single dose of T-2 toxin (0.08 mg · kg−1 body weight (BW) 72 h before slaughter) decreased cell proliferation, 2. chronic exposure to quercetin (1 mg · kg−1 BW; 90 days, 3 times per week) results in increased cell proliferation and reduced cell apoptosis, 3. quercetin has the potential to attenuate T-2 toxin-induced proliferation arrest. To clarify the mechanism of T-2 toxin and quercetin action in the rabbit ovary, further experiments are necessary.
Structural changes in femoral bone microstructure of female rabbits after intramuscular administration of quercetin
Ramona Babosova, Hana Duranova, Radoslav Omelka, Veronika Kovacova, Maria Adamkovicova, Birgit Grosskopf, Marcela Capcarova, Monika Martiniakova
Acta Veterinaria Scandinavica
Novel regulators of rabbit reproductive functions
Alexander V. Sirotkin, Peter Chrenek, Adriana Kolesarová, Francesco Parillo, Massimo Zerani, Cristiano Boiti
Animal Reproduction Science
Can xylene and quercetin directly affect basic ovarian cell functions?
Adam Tarko, Aneta Štochmalova, Sandra Hrabovszka, Adriana Vachanova, Abdel Halim Harrath, Roland Grossman, Alexander V. Sirotkin
Research in Veterinary Science
Nanoparticles as a Solution for Eliminating the Risk of Mycotoxins
Pavel Horky, Sylvie Skalickova, Daria Baholet, Jiri Skladanka
Mitochondrion: a new molecular target and potential treatment strategies against trichothecenes
Deyu Huang, Luqing Cui, Menghong Dai, Xu Wang, Qinghua Wu, Hafiz I. Hussain, Zonghui Yuan
Trends in Food Science & Technology
Effects of benzene, quercetin, and their combination on porcine ovarian cell proliferation, apoptosis, and hormone release
Adam Tarko, Aneta Štochmal'ová, Katarína Jedličková, Sandra Hrabovszká, Adriana Vachanová, Abdel Harrath, Saleh Alwasel, Abdulkarem Alrezaki, Jan Kotwica, Andrej Baláži, Alexander Sirotkin
Archives Animal Breeding
Antioxidant agents against trichothecenes: new hints for oxidative stress treatment
Qinghua Wu, Xu Wang, Eugenie Nepovimova, Yun Wang, Hualin Yang, Li Li, Xiujuan Zhang, Kamil Kuca
Effects of dietary supplementation with algae, sunflower oil or soybean oil on folliculogenesis in the rabbit ovary during sexual maturation
Malgorzata Grzesiak, Dorota Maj, Anna Hrabia
Acta Histochemica