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Photoperiod-dependent effect of inflammation on nocturnal gene expression of proinflammatory cytokines and their receptors in pars tuberalis of ewe

K. Król 1,  
A. P. Herman 1  
The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland
J. Anim. Feed Sci. 2016;25(1):3–11
Publication date: 2016-02-25
The study was designed to determine the influence of photoperiod on the nocturnal gene expression of proinflammatory cytokines such as interleukin (IL)-1β (IL1B), IL-6 (IL6), tumor necrosis factor α (TNF) and their receptors: IL-1 type I receptor (IL1R1), IL-6 receptor (IL6R), glycoprotein 130 (IL6ST), TNF type I and II receptors (TNFRSF1A and TNFRSF1B, respectively) in the pars tuberalis (PT) of ewe with the endotoxin-induced acute inflammation. The studies were performed on adult ewe (n = 24) in two photoperiods: long night (LN; 16:8; October) and short night (SN; 8:16; June). The animals from each photoperiod were divided into two groups: control (n = 6) and lipopolysaccharide (LPS)-treated (n = 6). All experiment steps were performed in the darkness. Two hours after the sunset the ewe received the intravenous injection of LPS or an appropriate volume of saline. Three hours after the injections all animals were slaughtered. It was found that melatonin concentration in control ovine serum was higher (P < 0.05) during LN than SN period. Endotoxin decreased (P < 0.05) the melatonin release only in ewe kept under SN condition. The transcripts encoding all examined proinflammatory cytokines and their receptors were expressed in the PT. Moreover, the PT collected from LPS-treated ewe during LN were characterized with higher (P < 0.05) expression of IL6, TNF, IL6ST, TNFRSF1A and TNFRSF1B genes compared with the tissues collected during SN. Similar influence of photoperiod was also observed in the case of TNF gene expression in the control sheep. Obtained results suggest that the PT may be one of the gateways for immune-endocrine interactions and these interactions may be affected by the photoperiod.
A. P. Herman   
The Kielanowski Institute of Animal Physiology and Nutrition Polish Academy of Sciences, Instytucka 3, 05-110 Jabłonna, Poland
1. Endotoxin-induced inflammation disturbs melatonin secretion in ewe
Andrzej Przemysław Herman, Karolina Wojtulewicz, Joanna Bochenek, Agata Krawczyńska, Hanna Antushevich, Bartosz Pawlina, Marlena Zielińska-Górska, Anna Herman, Katarzyna Romanowicz, Dorota Tomaszewska-Zaremba
Asian-Australasian Journal of Animal Sciences
2. Endotoxin-Induced Inflammation Suppresses the Effect of Melatonin on the Release of LH from the Ovine Pars Tuberalis Explants—Ex Vivo Study
Karolina Wojtulewicz, Dorota Tomaszewska-Zaremba, Andrzej Herman
3. The effect of inflammation on the synthesis of luteinizing hormone and GnRH receptor expression in the pars tuberalis of ewe during different photoperiodic conditions
Karolina Wojtulewicz, Dorota Tomaszewska-Zaremba, Agata Krawczyńska, Monika Tomczyk, Andrzej Przemysław Herman
Canadian Journal of Animal Science
4. Neostigmine Attenuates Proinflammatory Cytokine Expression in Preoptic Area but Not Choroid Plexus during Lipopolysaccharide-Induced Systemic Inflammation
Andrzej P. Herman, Dorota Tomaszewska-Zaremba, Marta Kowalewska, Aleksandra Szczepkowska, Małgorzata Oleszkiewicz, Agata Krawczyńska, Maciej Wójcik, Hanna Antushevich, Janina Skipor
Mediators of Inflammation
5. Photoperiodic conditions as a factor modulating leptin influence on pro-inflammatory cytokines and their receptors gene expression in ewe’s aorta
A. Krawczyńska, H. Antushevich, J. Bochenek, K. Wojtulewicz, B. Pawlina, A. Herman, D. Zięba
Journal of Animal and Feed Sciences
6. Effect of Central Injection of Neostigmine on the Bacterial Endotoxin Induced Suppression of GnRH/LH Secretion in Ewes during the Follicular Phase of the Estrous Cycle
Andrzej Herman, Janina Skipor, Agata Krawczyńska, Joanna Bochenek, Karolina Wojtulewicz, Bartosz Pawlina, Hanna Antushevich, Anna Herman, Dorota Tomaszewska-Zaremba
International Journal of Molecular Sciences
7. The Influence of Photoperiod on the Action of Exogenous Leptin on Gene Expression of Proinflammatory Cytokines and Their Receptors in the Thoracic Perivascular Adipose Tissue (PVAT) in Ewes
Agata Krawczyńska, Andrzej Herman, Hanna Antushevich, Joanna Bochenek, Karolina Wojtulewicz, Dorota Zięba
Mediators of Inflammation
8. Atypical gene expression of neuroinflammatory and steroid related genes following injury in the photoperiodic Japanese quail
Clara Arndtsen, Jason Ballon, Katie Blackshear, Cali Corbett, Kenneth Lee, Jordan Peyer, Kevin Holloway, Kelli Duncan
General and Comparative Endocrinology
9. The Impact of Photoperiod on the Leptin Sensitivity and Course of Inflammation in the Anterior Pituitary
Maciej Wójcik, Andrzej Herman, Dorota Zieba, Agata Krawczyńska
International Journal of Molecular Sciences
10. Effect of Acute and Prolonged Inflammation on the Gene Expression of Proinflammatory Cytokines and Their Receptors in the Anterior Pituitary Gland of Ewes
Karolina Wojtulewicz, Agata Krawczyńska, Dorota Tomaszewska-Zaremba, Maciej Wójcik, Andrzej Herman
International Journal of Molecular Sciences