0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
0.405
SJR
Q2
SJR
20
MNiSW
165.24
ICV
SHORT COMMUNICATION
 
CC-BY 4.0
 
 

Overnourishing pregnant adolescent ewes stimulates perirenal fat deposition in their growth restricted foetuses

M. Matsuzaki 1,  
J. S. Milne 2,  
R. P. Aitken 2,  
D. A. Redmer 3,  
 
1
Department of Animal and Grassland Research, National Agricultural Research Center for Kyushu Okinawa Region, Kumamoto 861-1192, Japan
2
Development, Growth and Function Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
3
Department of Animal and Range Sciences, North Dakota State University, Fargo ND 58105, USA
J. Anim. Feed Sci. 2004;13(Suppl. 1):519–522
Publish date: 2004-08-30
KEYWORDS
ABSTRACT
The influence of maternal nutrition during pregnancy on foetal adipose tissue development was studied in a sheep model of foetal growth restriction, achieved by overnourishing adolescent ewes. At Day 130 of gestation, the growth restricted foetuses from the overnourished rapidly growing dams (H) had higher perirenal fat proportions compared to control foetuses from the moderately fed adolescent dams (M). The mRNA expression for uncoupling protein (UCP)1 and leptin in foetal perirenal fat was equivalent between groups, but irrespective of maternal nutrition UCP1 was negatively correlated with foetal weight. Maternal plasma prolactin and glucose concentrations were higher in the H group and were positively associated with foetal perirenal fat deposition.
CORRESPONDING AUTHOR
J. M. Wallace   
Development, Growth and Function Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
 
CITATIONS (2):
1. Investigating the causes of low birth weight in contrasting ovine paradigms
J. M. Wallace, T. R. H. Regnault, S. W. Limesand, W. W. Hay, R. V. Anthony
The Journal of Physiology
2. Effects of overfeeding naturally-mated adolescent ewes on maternal, fetal, and postnatal lamb growth1
R. K. Peel, G. J. Eckerle, R. V. Anthony
Journal of Animal Science
ISSN:1230-1388