SHORT COMMUNICATION
Overnourishing pregnant adolescent ewes stimulates perirenal fat deposition in their growth restricted foetuses
,
 
,
 
,
 
,
 
 
 
More details
Hide details
1
Department of Animal and Grassland Research, National Agricultural Research Center for Kyushu Okinawa Region, Kumamoto 861-1192, Japan
2
Development, Growth and Function Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
3
Department of Animal and Range Sciences, North Dakota State University, Fargo ND 58105, USA
CORRESPONDING AUTHOR
J. M. Wallace   

Development, Growth and Function Division, Rowett Research Institute, Aberdeen AB21 9SB, UK
Publication date: 2004-08-30
 
J. Anim. Feed Sci. 2004;13(Suppl. 1):519–522
 
KEYWORDS
ABSTRACT
The influence of maternal nutrition during pregnancy on foetal adipose tissue development was studied in a sheep model of foetal growth restriction, achieved by overnourishing adolescent ewes. At Day 130 of gestation, the growth restricted foetuses from the overnourished rapidly growing dams (H) had higher perirenal fat proportions compared to control foetuses from the moderately fed adolescent dams (M). The mRNA expression for uncoupling protein (UCP)1 and leptin in foetal perirenal fat was equivalent between groups, but irrespective of maternal nutrition UCP1 was negatively correlated with foetal weight. Maternal plasma prolactin and glucose concentrations were higher in the H group and were positively associated with foetal perirenal fat deposition.
 
CITATIONS (3):
1.
Investigating the causes of low birth weight in contrasting ovine paradigms
J. M. Wallace, T. R. H. Regnault, S. W. Limesand, W. W. Hay, R. V. Anthony
The Journal of Physiology
 
2.
Effects of overfeeding naturally-mated adolescent ewes on maternal, fetal, and postnatal lamb growth1
R. K. Peel, G. J. Eckerle, R. V. Anthony
Journal of Animal Science
 
3.
Long-Term Consequences of Adaptive Fetal Programming in Ruminant Livestock
Allison Vautier, Caitlin Cadaret
Frontiers in Animal Science
 
ISSN:1230-1388