0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
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SJR
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SJR
20
MNiSW
165.24
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

Effects of active immunization against the recombinant second extracellular loop of sheep β2-adrenoceptor on growth and blood biochemical parameters of female rats

B. Yang 1,  
X. W. Bao 1,  
Q. Y. Guo 1,  
W. W. Dong 1,  
H. Y. Li 1,  
J. H. Gao 1,  
Y. Chen 1  
 
1
Xinjiang Agricultural University, The Xinjiang Key Laboratory of Meat and Milk-Production Herbivore Nutrition, Urumqi 830052, P.R. China
J. Anim. Feed Sci. 2012;21(3):493–502
Publish date: 2012-09-14
KEYWORDS
ABSTRACT
The objective of this study was to determine effects of active immunization against the recombinant second extracellular loop of sheep β2-adrenoceptor (rBAR) on growth performance, carcass parameters, internal organ weight, and some blood biochemical parameters of rats. Forty five six-week-old female Wistar rats were randomly allocated to three groups and received active immunization of rBAR (rBAR-immune group) or adjuvant by subcutaneous injection (contol goup), or oral administration of β-agonist clenbuterol hydrochloride (clenbuterol goup). Results showed that active immunization against rBAR displayed significant antibody titer responses. Growth performance, feed intake, carcass weight and leg muscle weight of rats were increased by oral administration of clenbuterol (P<0.05), but not by rBAR immunization. rBAR immunization increased weight of liver and lungs, and decreased blood urea nitrogen and triglycerides of rats (P<0.05). Abdomen fat weight and concentration of total cholesterol tended to decreased by rBAR immunization (P=0.11 and P=0.087). The results implied that antibody raised against the recombinant second extracellular loop of sheep β2-AR can mimic part functions of β-agonist.
CORRESPONDING AUTHOR
Y. Chen   
Xinjiang Agricultural University, The Xinjiang Key Laboratory of Meat and Milk-Production Herbivore Nutrition, Urumqi 830052, P.R. China
ISSN:1230-1388