Dietary coenzyme Q10 may improve the growth performance and antioxidant status in quails exposed to cold stress
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Dicle University, Department of Animal Husbandry, 21280, Diyarbakir, Turkey
Malatya Turgut Ozal University, Department of Zootechny, 44210, Malatya, Turkey
Balikesir University, Department of Biochemistry, 10145, Balikesir, Turkey
Balikesir University, Department of Pharmacology and Toxicology, 10145, Balikesir, Turkey
Publication date: 2020-03-31
Corresponding author
F. Akdemir   

Malatya Turgut Ozal University, Department of Zootechny, 44210, Malatya, Turkey
J. Anim. Feed Sci. 2020;29(1):67–74
In this study, the effects of coenzyme Q10 (CoQ10) on growth performance, antioxidant status and organ weights in cold-stressed Japanese quails (Coturnix coturnix japonica) were investigated. During the experiment, a 2 × 3 factorial design was employed with two environmental temperatures (ET) and three levels of CoQ10 (0, 20 and 40 mg/kg). A total of 180 one-day-old male quails were randomly allocated into 6 groups with 6 replicates with 5 birds in each replicate. The birds were fed in two separate rooms at either 22 ± 2 °C for 24 h/day (thermoneutral, TN) or 12 ± 2 °C for 8 h/day (cold stress, CS; between 09:00–17:00) followed by 22 ± 2 °C for 16 h/day. CoQ10 addition into diet increased final body weight, body weight gain and cumulative feed intake only in CS regardless of the used dose. It was stated that CoQ10 supplementation did not exert influence on serum and liver superoxide dismutase (SOD) activity and liver total antioxidant status (TAS) in TN conditions, but increased these parameters in CS; however in liver the higher CoQ10 dose was required to obtain the statistically positive effect. When quails were exposed to CS a higher dose of CoQ10 caused a more pronounced decreased in serum malondialdehyde (MDA) level than the lower one; however the effect of CoQ10 on liver MDA level was shown regardless of the used dose. The obtained results show that CoQ10 supplementation reverses the negative effects of CS on growth performance, antioxidant status and organ weights in quails. The caused may effects partly associated with direct antioxidant properties of CoQ10 as well as the synergistic efficacy of CoQ10 with SOD activity.
AOAC, 1990. Official Methods of Analysis of the Association of Official Analytical Chemists. 15th Edition. Arlington, VA (USA).
Bentinger M., Tekle M., Dallner G., 2010. Coenzyme Q – biosynthesis and functions. Biochem. Biophys. Res. Commun. 396, 74–79, https://doi.org/10.1016/j.bbrc....
Collin A., Buyse J., van As P., Darras V.M., Malheiros R.D., Moraes V.M.B., Reyns G.E., Taouis M., Decuypere E., 2003. Cold-induced enhancement of avian uncoupling protein expression, heat production, and triiodothyronine concentrations in broiler chicks. Gen. Comp. Endocrinol. 130, 70–77, https://doi.org/10.1016/S0016-....
de Barcelos I.P.D., Haas R.H., 2019. CoQ10 and aging. Biology. 8, 28, https://doi.org/10.3390/biolog....
Dhanalakshmi S., Devi R.S., Srikumar R., Manikandan S., Thangaraj R., 2007. Protective effect of Triphala on cold stress-induced behavioral and biochemical abnormalities in rats. Yakugaku Zasshi 127, 1863–1867, https://doi.org/10.1248/yakush....
Ernster L., Forsmark-Andrée P., 1993. Ubiquinol: an endogenous antioxidant in aerobic organisms. Clin. Invest. 71, S60–S65, https://doi.org/10.1007/BF0022....
Fathi M., 2015. Effects of coenzyme Q10 supplementation on growth performance, some hematological parameters, plasma enzymes activities in broilers with pulmonary hypertension syndrome (PHS). Iran. J. Appl. Anim. Sci. 5, 147–153.
Fu J., Liu C.-p., Zhang Z.-w., Xing M.-w., Xu S.-w., 2013. Influence of inflammatory pathway markers on oxidative stress induced by cold stress in intestine of quails. Res. Vet. Sci. 95, 495–501, https://doi.org/10.1016/j.rvsc....
Geng A.L., Guo Y.M., 2005. Effects of dietary coenzyme Q10 supplementation on hepatic mitochondrial function and the activities of respiratory chain-related enzymes in ascitic broiler chickens. Br. Poult. Sci. 46, 626–634, https://doi.org/10.1080/000716....
Halliwell B., Gutteridge J.M.C., 2015. Free Radicals in Biology and Medicine. 5th Edition. Oxford University Press Inc. New York, NY (USA), https://doi.org/10.1093/acprof....
Hangalapura B., 2006. Cold stress and immunity: Do chickens adapt to cold by trading-off immunity for thermoregulation? PhD Thesis.Wageningen Institute of Animal Sciences, Wageningen University and ResearchCentre. Wageningen (The Netherlands).
Kalantar M., Hosseini S.M., Hosseini M.R., Kalantar M.H., Farmanullah, Yang L.G., 2019. Effects of in ovo injection of coenzyme Q10 on hatchability, subsequent performance, and immunity of broiler chickens. BioMed Res. Int. 2019, 7167525, https://doi.org/10.1155/2019/7....
Konieczka P., Czauderna M., Rozbicka-Wieczorek A., Smulikowska S., 2015. The effect of dietary fat, vitamin E and selenium concentrations on the fatty acid profile and oxidative stability of frozen stored broiler meat. J. Anim. Feed Sci. 24, 244–251, https://doi.org/10.22358/jafs/....
Linnane A.W., Kios M., Vitetta L., 2007. Coenzyme Q10 – Its role as a prooxidant in the formation of superoxide anion/ hydrogen peroxide and the regulation of the metabolite. Mitochondrion 7, Suppl. 1, S51–S61, https://doi.org/10.1016/j.mito....
Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J., 1951. Protein measurement with Folin phenol reagent. J. Biol. Chem. 193, 265–275.
Matés J.M., Sánchez-Jiménez F., 1999. Antioxidant enzymes and their implications in pathophysiologic processes. Front Biosci. 4, d339–d345, https://doi.org/10.2741/A432.
Modi K., Santani D.D., Goyal R.K., Bhatt P.A., 2006. Effect of coenzyme Q10 on catalase activity and other antioxidant parameters in streptozotocin-induced diabetic rats. Biol. Trace Elem. Res. 109, 25–33, https://doi.org/10.1385/BTER:1....
Mozo J., Emre Y., Bouillaud F., Ricquier D., Criscuolo F., 2005. Thermoregulation: what role for UCPs in mammals and birds? Biosci. Rep. 25, 227–249, https://doi.org/10.1007/s10540....
Mujahid A., Furuse M., 2009. Oxidative damage in different tissues of neonatal chicks exposed to low environmental temperature. Comp. Biochem. Physiol. A Mol. Integr. Physiol. 152, 604–608, https://doi.org/10.1016/j.cbpa....
Nemati M.H., Shahir M.H., Harakinezhad M.T., Lotfalhian H., 2017. Cold-induced ascites in broilers: effects of vitamin C and coenzyme Q10. Braz. J. Poult. Sci. 19, 537–544, https://doi.org/10.1590/1806-9....
Overvad K., Diamant B., Holm L., Hølmer G., Mortensen S.A., Stender S., 1999. Coenzyme Q10 in health and disease. Eur. J. Clin. Nutr. 53, 764–770, https://doi.org/10.1038/sj.ejc....
Öztürk-Ürek R., Bozkaya L.A., Tarhan L., 2001. The effect of some antioxidant vitamin- and trace element-supplemented diets on activities of SOD, CAT, GSH-Px and LPO levels in chicken tissues. Cell Biochem. Funct. 19, 125–132, https://doi.org/10.1002/cbf.90....
Panda A.K., Ramarao S.V., Raju M.V.L.N., 2007. Effect of vitamin C supplementation on performance, immune response and antioxidant status of heat stressed White Leghron layers. Ind. J. Poult. Sci. 42, 169–173.
Rozbicka-Wieczorek A.J., Szarpak E., Brzóska F., Śliwiński B., Kowalczyk J., Czauderna M., 2012. Dietary lycopene, selenium compounds and fish oil affect the profile of fatty acids and oxidative stress in chicken breast muscle. J. Anim. Feed Sci. 21, 705–724, https://doi.org/10.22358/jafs/....
Şahin E., Gümüşlü S., 2004. Cold-stress-induced modulation of antioxidant defence: role of stressed conditions in tissue injury followed by protein oxidation and lipid peroxidation. Int. J. Biometeorol. 48, 165–171, https://doi.org/10.1007/s00484....
Sahin K., Kucuk O., 2003. Heat stress and dietary vitamin supplementation of poultry diets. Nutr. Abstr. Rev. Ser. B. Livest. Feeds Feeding 73, 41R–50R.
Schauer R., 1982. Chemistry, metabolism and biological functions of sialic acids. Adv. Carbohydr. Chem. Biochem. 40, 131–234, https://doi.org/10.1016/S0065-....
Siegel H.S., 1995. Stress, strains and resistance. Br. Poult. Sci. 36, 3–22, https://doi.org/10.1080/000716....
Sun Y., Oberley L.W., Li Y., 1988. A simple for clinical assay of superoxide dismutase. Clin. Chem. 34, 497–500, https://doi.org/10.1093/clinch....
Sunderman F.W., Nomoto S., 1970. Measurement of human serum ceruloplasmin by its p-phenylenediamine oxidase activity. Clin. Chem. 16, 903–910, https://doi.org/10.1093/clinch....
Tuzcu M., Sahin N., Karatepe M., Cikim G., Kilinc U., Sahin K., 2008. Epigallocatechin-3-gallate supplementation can improve antioxidant status in stressed quail. Br. Poult. Sci. 49, 643–648, https://doi.org/10.1080/000716....
Warren L., 1959. The thiobarbituric acid assay of sialic acids. J. Biol. Chem. 234, 1971–1975.
Yoshioka T., Kawada K., Shimada T., Mori M., 1979. Lipid peroxidation in maternal and cord blood and protective mechanism against activated-oxygen toxicity in the blood. Am. J. Obstet. Gynecol. 135, 372–376, https://doi.org/10.1016/0002-9....
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