ORIGINAL PAPER
Agaricus blazei Murrill stipe promotes growth by improving anti-inflammatory activity and gut function in broilers
1
Guangxi Academy of Agricultural Sciences, Guangxi Crop Genetic Improvement and Biotechnology Laboratory, 530007, Nanning, China
2
Guangxi Academy of Agricultural Sciences, Institute of Microbiology, 530007, Nanning, China
Publication date: 2023-07-24
J. Anim. Feed Sci. 2024;33(1):64-75
KEYWORDS
TOPICS
ABSTRACT
Agaricus blazei Murrill (AB) is a mushroom known for its medicinal
applications. AB stipe (ABS) is a by-product of the mushroom’s processing,
which is rich in bioactive substances, such as polysaccharides. This experiment
was conducted to assess the effects of dietary ABS supplementation on growth
performance, short-chain fatty acid production, antioxidant capacity, immune
function, meat quality, gut function, and caecal microbiota in broilers. A total of
180 one-day-old male Arbor Acre broilers (46.17 ± 2.47 g) were randomised
to 3 treatments, with 6 replicates per treatment and 10 broilers per replicate.
The treatments included one basal diet (control group) and two experimental
diets supplemented with 1% and 2% ABS, respectively. This trial lasted
42 days and was divided into Phase 1 (day 1–21) and Phase 2 (day 22–42).
The results showed that broilers fed ABS exhibited a significant reduction in
the feed conversion ratio throughout the study period (P < 0.05), and tended to
have increased average daily gain in Phase 2 (P < 0.1) and the overall period
(P < 0.1). On day 42, dietary ABS supplementation significantly decreased
the concentration of interleukin-1β (P < 0.05) and total cholesterol in serum
(P < 0.05). Moreover, ABS addition significantly increased the villus height-tocrypt
depth ratio (P < 0.05) in the jejunum and tended to increase villus height
(P < 0.1) and decrease crypt depth (P < 0.1). In addition, the ABS-supplemented
groups showed higher microbial diversity and increased proliferation of beneficial
bacteria in the caecum. Based on these findings, it can be concluded that ABS
supplementation can improve growth performance, anti-inflammatory activity,
and intestinal function.
FUNDING
This research was financially supported by the Science and Technology Base and Talent Project of Guangxi (Grant No. Guike AA21196003), China Agriculture Research System (CARS20), Special Fund for Basic Scientific Research of the Guangxi Academy of Agricultural Sciences (2023YM92), Science and Technology Development Fund of the Guangxi Academy of Agricultural Sciences (2023YM103).
CONFLICT OF INTEREST
The Authors declare that there is no conflict of interest.
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