ORIGINAL PAPER
Structure-activity relationships of preventive effects
of flavonoids in alloxan-induced diabetes mellitus
in rats
| 1 | Šafárik University, Faculty of Medicine,
Department of Physiology, 040 66 Košice, Slovak Republic |
| 2 | Šafárik University, Faculty of Medicine,
Department of Pharmacology, 040 66 Košice, Slovak Republic |
| 3 | Šafárik University, Faculty of Medicine,
Department of Pathological Physiology, 040 66 Košice, Slovak Republic |
CORRESPONDING AUTHOR
F. Ništiar
Šafárik University, Faculty of Medicine, Department of Pathological Physiology, 040 66 Košice, Slovak Republic
Šafárik University, Faculty of Medicine, Department of Pathological Physiology, 040 66 Košice, Slovak Republic
Publication date: 2008-06-24
J. Anim. Feed Sci. 2008;17(3):411–421
KEYWORDS
ABSTRACT
The effects of flavonoids quercetin (Q) and chrysin (Ch) were evaluated in rats with alloxan-induced
diabetes mellitus. A single dose of 60 mg alloxan (A) per kg body weight was injected to rats
fasting for at least 16 h. Q or Ch in amounts of 50 and 100 mg/kg body weight were administered
orally to the control non-treated and A treated rats (10 rats per group) for 3 days prior and 7 days
after A injection. Glycaemia, glycosuria, total antioxidant status (TAS) and activity of superoxide
dismutase (SOD) and glutathione peroxidase (GPx) were determined. Both Q and Ch prevented
serum glucose elevation due to A, but the effect of Ch was weaker, particularly at the higher dose.
The beneficial effects of flavonoids on glycosuria and antioxidant status differed between Q and Ch,
being generally greater in case of Q, and depended on the dose. It is suggested that the protective
effect of flavonoids under study is partly related to their antioxidative/chelatory properties and partly
to the alteration of renal glucose absorption.
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