0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
0.405
SJR
Q2
SJR
20
MNiSW
165.24
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

Structure-activity relationships of preventive effects of flavonoids in alloxan-induced diabetes mellitus in rats

J. Mojžiš 2,  
R. Beňačka 3,  
O. Rácz 3,  
F. Ništiar 3  
 
1
Šafárik University, Faculty of Medicine, Department of Physiology, 040 66 Košice, Slovak Republic
2
Šafárik University, Faculty of Medicine, Department of Pharmacology, 040 66 Košice, Slovak Republic
3
Šafárik University, Faculty of Medicine, Department of Pathological Physiology, 040 66 Košice, Slovak Republic
J. Anim. Feed Sci. 2008;17(3):411–421
Publish date: 2008-06-24
KEYWORDS
ABSTRACT
The effects of flavonoids quercetin (Q) and chrysin (Ch) were evaluated in rats with alloxan-induced diabetes mellitus. A single dose of 60 mg alloxan (A) per kg body weight was injected to rats fasting for at least 16 h. Q or Ch in amounts of 50 and 100 mg/kg body weight were administered orally to the control non-treated and A treated rats (10 rats per group) for 3 days prior and 7 days after A injection. Glycaemia, glycosuria, total antioxidant status (TAS) and activity of superoxide dismutase (SOD) and glutathione peroxidase (GPx) were determined. Both Q and Ch prevented serum glucose elevation due to A, but the effect of Ch was weaker, particularly at the higher dose. The beneficial effects of flavonoids on glycosuria and antioxidant status differed between Q and Ch, being generally greater in case of Q, and depended on the dose. It is suggested that the protective effect of flavonoids under study is partly related to their antioxidative/chelatory properties and partly to the alteration of renal glucose absorption.
CORRESPONDING AUTHOR
F. Ništiar   
Šafárik University, Faculty of Medicine, Department of Pathological Physiology, 040 66 Košice, Slovak Republic
 
CITATIONS (12):
1. Lifetime exposure to low doses of lead in rats
Jaroslava Nováková, Agnesa Lukačínová, Eva Lovásová, Iveta Cimboláková, Oliver Rácz, František Ništiar
Toxicology and Industrial Health
2. Antihypercholesterolemic and antioxidative effects of an extract of the oyster mushroom, Pleurotus ostreatus, and its major constituent, chrysin, in Triton WR-1339-induced hypercholesterolemic rats
Ramalingam Anandhi, Thangaraj Annadurai, Thirugnanasambandhar S. Anitha, Arumugam R. Muralidharan, Kalifulla Najmunnisha, Vasanthi Nachiappan, Philip A. Thomas, Pitchairaj Geraldine
Journal of Physiology and Biochemistry
3. In-vitro and in-vivo antiadipogenic, hypolipidemic and antidiabetic activity of Diospyros melanoxylon (Roxb)
Kalpana Rathore, Vijay Kumar Singh, Parag Jain, S. Prakash Rao, Zabeer Ahmed, Veena D. Singh
Journal of Ethnopharmacology
4. Antioxidant Strategies in the Management of Diabetic Neuropathy
Ayodeji Babatunde Oyenihi, Ademola Olabode Ayeleso, Emmanuel Mukwevho, Bubuya Masola
BioMed Research International
5. The antioxidant effect of the Malaysian Gelam honey on pancreatic hamster cells cultured under hyperglycemic conditions
Kalaivani Batumalaie, Rajes Qvist, Kamaruddin Mohd Yusof, Ikram Shah Ismail, Shamala Devi Sekaran
Clinical and Experimental Medicine
6. Effect of Gelam Honey on the Oxidative Stress-Induced Signaling Pathways in Pancreatic Hamster Cells
Kalaivani Batumalaie, Sher Zaman Safi, Kamaruddin Mohd Yusof, Ikram Shah Ismail, Shamala Devi Sekaran, Rajes Qvist
International Journal of Endocrinology
7. Effects of Consumption of Rooibos (Aspalathus linearis) and a Rooibos-Derived Commercial Supplement on Hepatic Tissue Injury bytert-Butyl Hydroperoxide in Wistar Rats
B. D. Canda, O. O. Oguntibeju, J. L. Marnewick
Oxidative Medicine and Cellular Longevity
8. The effect of dietary bee pollen intake on growth performance and biochemical indicators of rats
Branislav Gálik, Daniel Bíro, Milan Šimko, Miroslav Juráček, Marcela Capcarová, Adriana Kolesárová, Michal Rolinec, Róbert Toman, Tomáš Kanka
Acta Veterinaria Brno
9. Metabolic Syndrome and Neuroprotection
Melisa Etchegoyen, Mariana H. Nobile, Francisco Baez, Barbara Posesorski, Julian González, Néstor Lago, José Milei, Matilde Otero-Losada
Frontiers in Neuroscience
10. Genus Retama: a review on traditional uses, phytochemistry, and pharmacological activities
A. J. León-González, I. Navarro, N. Acero, D. Muñoz Mingarro, C. Martín-Cordero
Phytochemistry Reviews
11. Artemisia campestris L.: review on taxonomical aspects, cytogeography, biological activities and bioactive compounds
Ikram Dib, Fatima Ezzahra El Alaoui-Faris
Biomedicine & Pharmacotherapy
12. Natural Flavonoids as Potential Herbal Medication for the Treatment of Diabetes Mellitus and its Complications
Jian Chen, Sven Mangelinckx, An Adams, Zheng-tao Wang, Wei-lin Li, Norbert De Kimpe
Natural Product Communications
ISSN:1230-1388