Insuline like growth factors binding proteins (IGFBP 1-6) modulate action of insuline like growth factors (IGFs) - hormones engaged in the regulation of muscle growth of mammalian organism. The aim of our study was to analyse changes in the expression level of IGFBP-3 and IGFBP-5 genes in muscles during development of pigs (between 60 and 210 days of age) and to evaluate if there are differences in the expression level of these genes between groups of pigs representing different breeds. We did not observe a significant changes in IGFBP-5 mRNA level during postnatal development of pigs. However, IGFBP-3 was shown overexpressed at the early developmental stages, when compared to late developmental stages. The intra-breed analyses revealed that IGFBP-5 mRNA level was significantly lower in Duroc pigs and tract of IGFBP-3 was significantly higher in Pietrain pigs than in the other investigated breeds: Puławska, Polish Large White and Polish Landrace.