Analysis of skeletal malformations in embryos that died between day 17 and 21 of incubation
obtained from two reproductive flocks of broiler chickens showed exencephaly to be the most
common defect. It comprises about 48% of all diagnosed axial skeleton disorders. Analysis of the
expression of Hoxa1 and Hoxd3 genes by real time PCR revealed upregulation of Hoxa1 in chicken
embryos with exencephaly (16.8-fold higher), when compared with healthy birds. Upregulation of
Hoxa1 suggests that this gene may be associated with exencephaly in chickens.
CITATIONS(6):
1.
Identification of Genes Related to Beak Deformity of Chickens Using Digital Gene Expression Profiling Hao Bai, Jing Zhu, Yanyan Sun, Ranran Liu, Nian Liu, Dongli Li, Jie Wen, Jilan Chen, Marinus FW. te Pas PLoS ONE
Study on LOC426217 as a candidate gene for beak deformity in chicken Hao Bai, Yanyan Sun, Jing Zhu, Nian Liu, Dongli Li, Fuguang Xue, Yunlei Li, Jilan Chen BMC Genetics
Single SNP- and pathway-based genome-wide association studies for beak deformity in chickens using high-density 600K SNP arrays Hao Bai, Yanyan Sun, Nian Liu, Fuguang Xue, Yunlei Li, Songshan Xu, Jianhua Ye, Lei Zhang, Yu Chen, Jilan Chen BMC Genomics
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