ORIGINAL PAPER
Effects of sodium butyrate on the growth
performance, intestinal microflora and morphology
of weanling pigs
| 1 | Key Laboratory of Molecular Animal Nutrition, Education Ministry,
Feed Science Institute, Animal Science College, Zhejiang University,
Hangzhou 310029, P.R. China |
CORRESPONDING AUTHOR
J. J. Lu
Key Laboratory of Molecular Animal Nutrition, Education Ministry, Feed Science Institute, Animal Science College, Zhejiang University, Hangzhou 310029, P.R. China
Key Laboratory of Molecular Animal Nutrition, Education Ministry, Feed Science Institute, Animal Science College, Zhejiang University, Hangzhou 310029, P.R. China
Publication date: 2008-10-27
J. Anim. Feed Sci. 2008;17(4):568–578
KEYWORDS
ABSTRACT
A total of 96 pigs (Duroc×Landrace×Yorkshire) weaned at day 21 with an average initial body
weight of 6.68 kg were used to investigate the effects of sodium butyrate on the growth performance,
intestinal microflora and morphology of weanling pigs. The pigs were allocated to three dietary
treatments in a randomized complete block design, each treatment was replicated four times with
eight pigs per replicate and the trial lasted for 30 days. The dietary treatments were: 1. basal diet,
2. basal diet + 500 mg/kg sodium butyrate, 3. basal diet + 1000 mg/kg sodium butyrate. Diets were
formulated according to requirements of NRC (1998) for 10-20 kg pigs. All diets were fed as mash,
and no antibiotics was included. The results showed that supplementation with 1000 mg/kg sodium
butyrate improved (P<0.05) growth performance, reduced (P<0.05) the total viable counts of intestinal
Clostridium and Escherichia coli, decreased (P<0.05) tumor necrosis factor-α (TNF-α) and interleukin-
6 (IL-6) levels in the serum, and increased (P<0.05) villus height and the villus height to crypt depth
ratio at the small intestinal mucosa as compared with control. The results indicated that sodium butyrate
is effective in enhancing the growth and intestinal morphology of weanling pigs.
CITATIONS (33):
1.
The effect of coated sodium butyrate supplementation in sow and nursery diets on lactation performance and nursery pig growth performance
Y.D. Jang, M.D. Lindemann, H.J. Monegue, J.S. Monegue
Livestock Science
Y.D. Jang, M.D. Lindemann, H.J. Monegue, J.S. Monegue
Livestock Science
2.
The use of medium chain fatty acids in piglet feeding – a review
Ewa Hanczakowska
Annals of Animal Science
Ewa Hanczakowska
Annals of Animal Science
3.
Effects of sodium butyrate supplementation on reproductive performance and colostrum composition in gilts
B. He, M. Wang, H. Guo, Y. Jia, X. Yang, R. Zhao
animal
B. He, M. Wang, H. Guo, Y. Jia, X. Yang, R. Zhao
animal
4.
Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid
Yongqing Hou, Lei Wang, Dan Yi, Binying Ding, Xing Chen, Qingjing Wang, Huiling Zhu, Yulan Liu, Yulong Yin, Joshua Gong, Guoyao Wu
British Journal of Nutrition
Yongqing Hou, Lei Wang, Dan Yi, Binying Ding, Xing Chen, Qingjing Wang, Huiling Zhu, Yulan Liu, Yulong Yin, Joshua Gong, Guoyao Wu
British Journal of Nutrition
5.
Effects of Tributyrin on Intestinal Energy Status, Antioxidative Capacity and Immune Response to Lipopolysaccharide Challenge in Broilers
Jiaolong Li, Yongqing Hou, Dan Yi, Jun Zhang, Lei Wang, Hongyi Qiu, Binying Ding, Joshua Gong
Asian-Australasian Journal of Animal Sciences
Jiaolong Li, Yongqing Hou, Dan Yi, Jun Zhang, Lei Wang, Hongyi Qiu, Binying Ding, Joshua Gong
Asian-Australasian Journal of Animal Sciences
6.
Effect of sodium butyrate and Yucca schidigera extract on bone characteristics in growing pigs
Iwona Puzio, Jose Luis Valverde Piedra, Małgorzata Kapica, Radosław P. Radzki, Marek Bieńko, Marta Pawłowska, Sylwia Szymańczyk
Journal of Veterinary Research
Iwona Puzio, Jose Luis Valverde Piedra, Małgorzata Kapica, Radosław P. Radzki, Marek Bieńko, Marta Pawłowska, Sylwia Szymańczyk
Journal of Veterinary Research
7.
Sodium butyrate improved intestinal immune function associated with NF-κB and p38MAPK signalling pathways in young grass carp ( Ctenopharyngodon idella )
Li Tian, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Fei Xie, Lin Feng
Fish & Shellfish Immunology
Li Tian, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Pei Wu, Jun Jiang, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Yong-An Zhang, Fei Xie, Lin Feng
Fish & Shellfish Immunology
8.
Supplementation of tributyrin improves the growth and intestinal digestive and barrier functions in intrauterine growth-restricted piglets
Li Dong, Xiang Zhong, Jintian He, Lili Zhang, Kaiwen Bai, Wen Xu, Tian Wang, Xuexin Huang
Clinical Nutrition
Li Dong, Xiang Zhong, Jintian He, Lili Zhang, Kaiwen Bai, Wen Xu, Tian Wang, Xuexin Huang
Clinical Nutrition
9.
Effect of Ca-butyrate and Oleobiotec (a flavouring agent) supplemented starter on the performance of Holstein dairy calves
A. R. DAVARMANESH, M. H. FATHI NASRI, A. R. KALANTARI FIROUZABAD, M. B. MONTAZER-TORBATI
The Journal of Agricultural Science
A. R. DAVARMANESH, M. H. FATHI NASRI, A. R. KALANTARI FIROUZABAD, M. B. MONTAZER-TORBATI
The Journal of Agricultural Science
10.
Sodium butyrate enhances intestinal integrity, inhibits mast cell activation, inflammatory mediator production and JNK signaling pathway in weaned pigs
Chun Chun Wang, Huan Wu, Fang Hui Lin, Rong Gong, Fei Xie, Yan Peng, Jie Feng, Cai Hong Hu
Innate Immunity
Chun Chun Wang, Huan Wu, Fang Hui Lin, Rong Gong, Fei Xie, Yan Peng, Jie Feng, Cai Hong Hu
Innate Immunity
11.
Sodium butyrate enhanced physical barrier function referring to Nrf2, JNK and MLCK signaling pathways in the intestine of young grass carp ( Ctenopharyngodon idella )
Pei Wu, Li Tian, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Jun Jiang, Fei Xie, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Juan Yang, Yong-An Zhang, He-Qun Shi, Lin Feng
Fish & Shellfish Immunology
Pei Wu, Li Tian, Xiao-Qiu Zhou, Wei-Dan Jiang, Yang Liu, Jun Jiang, Fei Xie, Sheng-Yao Kuang, Ling Tang, Wu-Neng Tang, Juan Yang, Yong-An Zhang, He-Qun Shi, Lin Feng
Fish & Shellfish Immunology
12.
Evaluation of different protections of butyric acid aiming for release in the last part of the gastrointestinal tract of piglets
J. J. Mallo, A. Balfagón, M. I. Gracia, P. Honrubia, M. Puyalto
Journal of Animal Science
J. J. Mallo, A. Balfagón, M. I. Gracia, P. Honrubia, M. Puyalto
Journal of Animal Science
13.
Arabinoxylan in Wheat Is More Responsible Than Cellulose for Promoting Intestinal Barrier Function in Weaned Male Piglets1–3
Hong Chen, Wei Wang, Jeroen Degroote, Sam Possemiers, Daiwen Chen, Stefaan De Smet, Joris Michiels
The Journal of Nutrition
Hong Chen, Wei Wang, Jeroen Degroote, Sam Possemiers, Daiwen Chen, Stefaan De Smet, Joris Michiels
The Journal of Nutrition
14.
Dietary Sodium Butyrate Decreases Postweaning Diarrhea by Modulating Intestinal Permeability and Changing the Bacterial Communities in Weaned Piglets1–3
Chang Huang, Peixia Song, Peixin Fan, Chengli Hou, Phil Thacker, Xi Ma
The Journal of Nutrition
Chang Huang, Peixia Song, Peixin Fan, Chengli Hou, Phil Thacker, Xi Ma
The Journal of Nutrition
15.
Nutritional Intervention for the Intestinal Development and Health of Weaned Pigs
Xia Xiong, Bie Tan, Minho Song, Peng Ji, Kwangwook Kim, Yulong Yin, Yanhong Liu
Frontiers in Veterinary Science
Xia Xiong, Bie Tan, Minho Song, Peng Ji, Kwangwook Kim, Yulong Yin, Yanhong Liu
Frontiers in Veterinary Science
16.
Molecular characterization of G-type lysozyme from juvenile golden pompano Trachinotus ovatus and the regulation of its activity and expression by dietary sodium butyrate levels
Chuanpeng Zhou, Heizhao Lin, Zhong Huang, Jun Wang, Yun Wang, Wei Yu
Aquaculture Reports
Chuanpeng Zhou, Heizhao Lin, Zhong Huang, Jun Wang, Yun Wang, Wei Yu
Aquaculture Reports
17.
Sodium butyrate maintains growth performance by regulating the immune response in broiler chickens
W.H. Zhang, Y. Jiang, Q.F. Zhu, F. Gao, S.F. Dai, J. Chen, G.H. Zhou
British Poultry Science
W.H. Zhang, Y. Jiang, Q.F. Zhu, F. Gao, S.F. Dai, J. Chen, G.H. Zhou
British Poultry Science
18.
Effect of benzoic acid, sodium butyrate and sodium butyrate coated with benzoic acid on growth performance, digestibility, intestinal morphology and meat quality in grower-finisher pigs
P.C.H. Morel, K.L. Chidgey, C.M.C. Jenkinson, I. Lizarraga, N.M. Schreurs
Livestock Science
P.C.H. Morel, K.L. Chidgey, C.M.C. Jenkinson, I. Lizarraga, N.M. Schreurs
Livestock Science
19.
Modification of ileal proteome in growing pigs by dietary supplementation with inulin or dried chicory root
A. Lepczyński, A. Herosimczyk, M. Ożgo, M. Barszcz, M. Taciak, J. Skomiał
Journal of Animal and Feed Sciences
A. Lepczyński, A. Herosimczyk, M. Ożgo, M. Barszcz, M. Taciak, J. Skomiał
Journal of Animal and Feed Sciences
20.
Response of gastrointestinal fermentative activity and colonic microbiota to protected sodium butyrate and protected sodium heptanoate in weaned piglets challenged with ETEC F4+
Paola López-Colom, Lorena Castillejos, Emili Barba-Vidal, Yanan Zhu, Mónica Puyalto, Juan Mallo, Susana Martín-Orúe
Archives of Animal Nutrition
Paola López-Colom, Lorena Castillejos, Emili Barba-Vidal, Yanan Zhu, Mónica Puyalto, Juan Mallo, Susana Martín-Orúe
Archives of Animal Nutrition
21.
Effects of dietary sodium butyrate on growth, diet conversion, body chemical compositions and distal intestinal health in yellow drum (Nibea albiflora
, Richardson)
Xun Wu, Ligai Wang, Qingping Xie, Peng Tan
Aquaculture Research
Xun Wu, Ligai Wang, Qingping Xie, Peng Tan
Aquaculture Research
22.
Dietary supplementation of sodium butyrate for mixed-parity sows during lactation
E.H.M. Vieira, P.H. Watanabe, T.S. Andrade, G.G.A. Araújo, B.A.N. Silva, R.R.S. Pinheiro, I.B. Mendonça
Livestock Science
E.H.M. Vieira, P.H. Watanabe, T.S. Andrade, G.G.A. Araújo, B.A.N. Silva, R.R.S. Pinheiro, I.B. Mendonça
Livestock Science
23.
Casein hydrolysate supplementation in low‐crude protein diets increases feed intake and nitrogen retention without affecting nitrogen utilization of growing pigs
Junhua Shen, Huisong Wang, Yu Pi, Kan Gao, Weiyun Zhu
Journal of the Science of Food and Agriculture
Junhua Shen, Huisong Wang, Yu Pi, Kan Gao, Weiyun Zhu
Journal of the Science of Food and Agriculture
24.
Response to a Salmonella Typhimurium challenge in piglets supplemented with protected sodium butyrate or Bacillus licheniformis: effects on performance, intestinal health and behavior1,2
E. Barba-Vidal, V. Roll, L. Castillejos, A. Guerra-Ordaz, X. Manteca, J. Mallo, S. Martín-Orúe
Translational Animal Science
E. Barba-Vidal, V. Roll, L. Castillejos, A. Guerra-Ordaz, X. Manteca, J. Mallo, S. Martín-Orúe
Translational Animal Science
25.
Effect of tributyrin supplementation in high‐soya bean meal diet on growth performance, body composition, intestine morphology and microbiota of juvenile yellow drum (
Nibea albiflora
)
Peng Tan, Xun Wu, Wenliang Zhu, Bao Lou, Ruiyi Chen, Ligai Wang
Aquaculture Research
Peng Tan, Xun Wu, Wenliang Zhu, Bao Lou, Ruiyi Chen, Ligai Wang
Aquaculture Research
27.
The effects of dietary sodium butyrate supplementation on the growth performance, carcass traits and intestinal microbiota of growing‐finishing pigs
W. Sun, J. Sun, M. Li, Q. Xu, X. Zhang, Z. Tang, J. Chen, J. Zhen, Z. Sun
Journal of Applied Microbiology
W. Sun, J. Sun, M. Li, Q. Xu, X. Zhang, Z. Tang, J. Chen, J. Zhen, Z. Sun
Journal of Applied Microbiology
28.
Effects of coated sodium butyrate on performance, diarrhea, intestinal microflora and barrier function of pigs during the first 2-week post-weaning
Fanghui Lin, Xin Li, Jiashu Wen, Chunchun Wang, Yan Peng, Jie Feng, Caihong Hu
Animal Feed Science and Technology
Fanghui Lin, Xin Li, Jiashu Wen, Chunchun Wang, Yan Peng, Jie Feng, Caihong Hu
Animal Feed Science and Technology
29.
Sodium Butyrate Protects the Intestinal Barrier by Modulating Intestinal Host Defense Peptide Expression and Gut Microbiota After a Challenge With Deoxynivalenol in Weaned Piglets
Shuai Wang, Cong Zhang, Jiacheng Yang, Xu Wang, Kuntan Wu, Beiyu Zhang, Jiacai Zhang, Ao Yang, Shahid Rajput, Desheng Qi
Journal of Agricultural and Food Chemistry
Shuai Wang, Cong Zhang, Jiacheng Yang, Xu Wang, Kuntan Wu, Beiyu Zhang, Jiacai Zhang, Ao Yang, Shahid Rajput, Desheng Qi
Journal of Agricultural and Food Chemistry
30.
Evaluation of equine rectal inoculum as representative of the microbial activities within the horse hindgut using a fully automated in vitro gas production technique system
Theresa Kujawa, Doorn van, Wendy Wambacq, Myriam Hesta, Wilbert Pellikaan
Journal of Animal Science
Theresa Kujawa, Doorn van, Wendy Wambacq, Myriam Hesta, Wilbert Pellikaan
Journal of Animal Science
31.
Coated sodium butyrate supplementation to a reduced nutrient diet enhanced the performance and positively impacted villus height and faecal and digesta bacterial composition in weaner pigs
Santi Upadhaya, Jiao Yang, Yong Kim, Kwang Lee, In Kim
Animal Feed Science and Technology
Santi Upadhaya, Jiao Yang, Yong Kim, Kwang Lee, In Kim
Animal Feed Science and Technology
32.
Supplementation of a soybean oil-based diet with tributyrin influences growth, muscle composition, intestinal morphology, and expression of immune-related genes of juvenile yellow drum (Nibea albiflora Richardson, 1846)
Wenliang Zhu, Peng Tan, Bao Lou, Ruiyi Chen, Ligai Wang, Dongdong Xu
Aquaculture International
Wenliang Zhu, Peng Tan, Bao Lou, Ruiyi Chen, Ligai Wang, Dongdong Xu
Aquaculture International
33.
Effects of sodium butyrate stimulation on immune‐related mRNA‐miRNA network in intestine of grass carp
Xiangbei Tang, Jianzhou Tang, Yi Zhou, Fufa Qu, Jun Zou, Tiaoyi Xiao, Zhen Liu
Aquaculture Research
Xiangbei Tang, Jianzhou Tang, Yi Zhou, Fufa Qu, Jun Zou, Tiaoyi Xiao, Zhen Liu
Aquaculture Research
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