ORIGINAL PAPER
Effects of sodium butyrate on the growth
performance, intestinal microflora and morphology
of weanling pigs
1
Key Laboratory of Molecular Animal Nutrition, Education Ministry,
Feed Science Institute, Animal Science College, Zhejiang University,
Hangzhou 310029, P.R. China
Publication date: 2008-10-27
Corresponding author
J. J. Lu
Key Laboratory of Molecular Animal Nutrition, Education Ministry, Feed Science Institute, Animal Science College, Zhejiang University, Hangzhou 310029, P.R. China
Key Laboratory of Molecular Animal Nutrition, Education Ministry, Feed Science Institute, Animal Science College, Zhejiang University, Hangzhou 310029, P.R. China
J. Anim. Feed Sci. 2008;17(4):568-578
KEYWORDS
ABSTRACT
A total of 96 pigs (Duroc×Landrace×Yorkshire) weaned at day 21 with an average initial body
weight of 6.68 kg were used to investigate the effects of sodium butyrate on the growth performance,
intestinal microflora and morphology of weanling pigs. The pigs were allocated to three dietary
treatments in a randomized complete block design, each treatment was replicated four times with
eight pigs per replicate and the trial lasted for 30 days. The dietary treatments were: 1. basal diet,
2. basal diet + 500 mg/kg sodium butyrate, 3. basal diet + 1000 mg/kg sodium butyrate. Diets were
formulated according to requirements of NRC (1998) for 10-20 kg pigs. All diets were fed as mash,
and no antibiotics was included. The results showed that supplementation with 1000 mg/kg sodium
butyrate improved (P<0.05) growth performance, reduced (P<0.05) the total viable counts of intestinal
Clostridium and Escherichia coli, decreased (P<0.05) tumor necrosis factor-α (TNF-α) and interleukin-
6 (IL-6) levels in the serum, and increased (P<0.05) villus height and the villus height to crypt depth
ratio at the small intestinal mucosa as compared with control. The results indicated that sodium butyrate
is effective in enhancing the growth and intestinal morphology of weanling pigs.
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