1.054
IF5
1.150
IF
Q3
JCR
1.7
CiteScore
0.396
SJR
Q2
SJR
40
MNiSW
148.75
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

Associations between polymorphism within regulatory and coding fragments of bovine kappa-casein gene and milk performance traits

 
1
Department of Animal Genetics, University of Warmia and Masuria in Olsztyn, Oczapowskiego 5, 10-718 Olsztyn, Poland
J. Anim. Feed Sci. 2000;9(3):435–446
Publication date: 2000-07-15
KEYWORDS
ABSTRACT
In Black-and-White dairy cattle, the kappa-casein gene (CASK) appears in three o f the most common genotypes, AA , AB, and BB . Apart from the coding sequence, several point mutations within the CASK gene promoter have been found. In this report, the hypothesis on the relationship between A/B polymorphism within exon IV and the promoter of CASK gene with milk performance traits is verified. One hundred and twenty four Black-and-White cows held in one herd were genotyped for two polymorphisms called CASK (exon IV, A and B allele) and CASK-R (kappa-casein promoter, Dde I restriction site in position -385, P and M allele). Sixty-nine AA, 48 AB and 7 BB CASK cows, and 92 PP, 30 PM and 2 MM CASK-R cows were identified. Associations between single CASK genotypes, single CASK-R genotypes as well as intragenic haplotypes CASK/CASK-R and milk performance traits were investigated. Significant differences (P<0.01) were found only for milk protein percentage. Cows with the PM CASK-R genotype and AA/PM intragenic haplotype showed the highest protein percentage. This is the first report showing the associations between mutations with in the promoter of the CASK gene, intragenic CASK haplotypes, and milk protein percentage. Our results support the hypothesis suggested in the literature that mutations within regulatory sequences of the CASK gene may influence the expression of milk protein genes.
 
CITATIONS (3):
1. Towards an integrated approach to study SNPs and expression of candidate genes associated with milk protein biosynthesis
S. Kamiński, T. Malewski, A. Ahman, E. Wójcik, A. Ruść, K. Oleński, A. Jakubczak, A. A. Sazanov
Russian Journal of Genetics
2. Analysis of genetic variations across regulatory and coding regions of kappa-casein gene of Indian native cattle (Bos indicus) and buffalo (Bubalus bubalis)
Amit Kishore, M. Mukesh, R.C. Sobti, R.S. Kataria, B.P. Mishra, Monika Sodhi
Meta Gene
3. Lactational traits of importance in dairy cows and applications for emerging biotechnologies
SR Davis
New Zealand Veterinary Journal
ISSN:1230-1388