1.054
IF5
1.150
IF
Q3
JCR
1.7
CiteScore
0.396
SJR
Q2
SJR
40
MNiSW
148.75
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

The influence of genistein on insulin, leptin, thyroid hormones and metabolic parameters in mature rats

T. Szkudelski 1,  
K. Szkudelska 1,  
 
1
Poznań University of Life Sciences, Department of Animal Physiology and Biochemistry, Wołyńska 35, 60-637 Poznań, Poland
J. Anim. Feed Sci. 2012;21(1):168–176
Publication date: 2012-03-15
KEYWORDS
ABSTRACT
Genistein is a phytoestrogen and is found in many plants consumed by humans and animals. This isoflavone was found to exert metabolic effects, especially on lipid and carbohydrate metabolism. The aim of this experiment was to determine whether genistein at a dose of 1 and 5 mg/kg body weight administered intragastrically to male and female adult rats changes insulin, leptin, thyroid hormone, and metabolic parameters. The results suggest that genistein has only a slight influence on metabolism. A substantial reduction of triglyceride stores was observed in the skeletal muscles. This effect was sex-dependent and occurred only in females. Moreover, it was demonstrated that genistein at the higher dose decreased blood insulin and leptin levels.
CORRESPONDING AUTHOR
E. Nowicka-Stańczyk   
Poznań University of Life Sciences, Department of Animal Physiology and Biochemistry, Wołyńska 35, 60-637 Poznań, Poland
 
CITATIONS (3):
1. Hormonally active phytochemicals and vertebrate evolution
Max R. Lambert, Thea M. Edwards
Evolutionary Applications
2. Effects of Dietary Protein on Thyroid Axis Activity
Nutrients
3. The potential beneficial role of isoflavones in type 2 diabetes mellitus
K.C. Duru, E.G. Kovaleva, I.G. Danilova, P van der Bijl, A.V. Belousova
Nutrition Research
ISSN:1230-1388