SHORT COMMUNICATION
Reduction of lactational performance following bovine TNF-α administration to dairy cows
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1
Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland, Science, Tsukuba, Ibaraki, 305-0901, Japan
 
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School of Veterinary Medicine and Animal Sciences, Kitasato University, Towada, Aomori, 034-8628, Japan
 
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Department of Animal Production and Grasslands Farming, National Agricultural Research, Center for Tohoku Region, Morioka, Iwate, 020-0198, Japan
 
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Graduate School of Agricultural Science, Factory of Agriculture, Tohoku University, Sendai, Miyagi, 981-8555, Japan
 
 
Publication date: 2004-08-30
 
 
Corresponding author
S. Kushibiki   

Department of Animal Physiology and Nutrition, National Institute of Livestock and Grassland, Science, Tsukuba, Ibaraki, 305-0901, Japan
 
 
J. Anim. Feed Sci. 2004;13(Suppl. 1):597-600
 
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ABSTRACT
Twelve lactating Holstein cows were injected subcutaneously with recombinant bovine Tumor Necrosis Factor-α (rbTNF, 2.5 µg/kg/day) or saline (3 ml/head/day) at 12.00 h daily for 7 d (d 0 - 6). Milk yield was reduced by rbTNF injection from d 1 to 8. The milk fat content was increased on d 1-7 by rbTNF treatment, but milk protein content in the rbTNF group was decreased on d 5 and 7 as compared with that of the control group. The somatotropin (ST) response to ST-releasing hormone (0.25 µg/kg) was smaller in the rbTNF group than in the control. These results support the possibility that TNF is responsible for the changes in hormone secretion, milk production and composition observed during coliform mastitis.
ISSN:1230-1388
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