REVIEW PAPER
Recent studies on molecular mechanisms involved in mammalian sperm capacitation: A review
 
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Department of Bioengineering, Faculty of Biotechnology, Rzeszów University, 36-100 Kolbuszowa, Poland
CORRESPONDING AUTHOR
L. Kątska-Książkiewicz   

Department of Bioengineering, Faculty of Biotechnology, Rzeszów University, 36-100 Kolbuszowa, Poland
Publication date: 2007-09-06
 
J. Anim. Feed Sci. 2007;16(3):311–328
 
KEYWORDS
ABSTRACT
Sperm capacitation is a physiological event that allows sperm to bind and fuse with the oocyte. Changes associated with this process include removal of cholesterol from the plasma membrane, increases in pH and Ca+2, activation of first and second messenger cascades, an increase in respiration and subsequent changes in the sperm motility pattern. The most significant change in sperm after capacitation is its ability to undergo the acrosome reaction. The purpose of this review is to present some recent achievements towards understanding the molecular mechanisms of mammalian sperm capacitation. The review focuses on regulation of sperm function by seminal plasma derived first messengers, i.e. fertilizationpromoting peptide (FPP), adenosine, calcitonin and angiotensin II, acting to affect production of a second messenger, cAMP. It also discusses the roles in sperm capacitation of speradhesins, platelet-activating factor (PAF) and PAF-acetylhydrolase, roles of Ca+2 ions, bicarbonate ions, and intracellular pH, roles of calmodulin and 1, 4, 5-triphosphate (IP3), protein tyrosine phosphorylation and actin polymerization, protein translation as well as hyperactivation and acrosome reaction as a final step of capacitation.
 
CITATIONS (5):
1.
Biochemical identification and characterisation of changes associated with capacitation of mannosylated glycoproteins in murine sperm
S.-C. Wu, H.-T. Yang, M. Liu
Andrologia
 
2.
Sequestration of PDC-109 Protein by Specific Antibodies and Egg Yolk Cryoprotects Bull Spermatozoa
N Srivastava, SK Srivastava, SK Ghosh, A Jerome, GK Das, S Mehrotra
Reproduction in Domestic Animals
 
3.
Can the Controversy About the Putative Role of the Human Female Orgasm in Sperm Transport be Settled with Our Current Physiological Knowledge of Coitus?
Roy J. Levin
The Journal of Sexual Medicine
 
4.
Capacitation-Associated Glycocomponents of Mammalian Sperm
Min Liu
Reproductive Sciences
 
5.
The achievement of boar sperm in vitro capacitation is related to an increase of disrupted disulphide bonds and intracellular reactive oxygen species levels
R. P. Betarelli, M. Rocco, M. Yeste, J. M. Fernández-Novell, A.  Placci, B. Azevedo Pereira, M. Castillo-Martín, E. Estrada, A. Peña, M. G. Zangeronimo, J. E. Rodríguez-Gil
Andrology
 
ISSN:1230-1388