0.857
IF5
0.900
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JCR
0.92
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MNiSW
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ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

Liver and body mass gain, content of conjugated linoleic acid (CLA) isomers and other fatty acids in the liver of rats fed CLA isomers and selenium

M. Czauderna 1  ,  
J. Kowalczyk 1,  
I. Wąsowska 1,  
E. Bulska 2,  
 
1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
2
Faculty of Chemistry, Warsaw University, Pasteura 1, 02-093 Warsaw, Poland
J. Anim. Feed Sci. 2004;13(2):353–369
Publish date: 2004-04-09
KEYWORDS
ABSTRACT
The influence of selenium (as Na2SeO4) and/or conjugated linoleic acid isomers (CLA) on relative body mass gain of rats, liver weight, concentrations of CLA isomers and of other fatty acids in the rat liver were investigated. Feeding selenium (Se) and/or CLA resulted in small changes in the relative body mass and liver mass gain of rats. The administered CLA isomers significantly elevated the concentration of CLA isomers and non-CLA fatty acids containing conjugated double bonds (CFA) in the liver. Addition of Se to a diet enriched in CLA isomers generally stimulated the accumulation of CLA isomers and CFA in the liver. Our results demonstrate that the trans-trans CLA isomers are catabolized more slowly and are poor substrates for β-oxidation. The cis-trans/trans-cis CLA isomers are rapidly metabolized to form longer-chain fatty acids containing conjugated double bonds, and are partly β-oxidized. Dietary supplementation to 1% of a mixture of CLA isomers or individual CLA isomers, regardless of the presence of Se in the diets, resulted in a reduction of the sum of all assayed fatty acids, saturated fatty acids (SFA), PUFA and MUFA. Our study demonstrated that dietary CLA isomers, regardless of the presence Se in the diet, caused a reduction in Δ9-desaturase capacity, inhibited steaoryl-CoA desaturase mRNA expression, and fatty acid synthesis. As a result, the value of the concentration ratio of oleic acid to C18:0 (i.e. RC18:0/oleic acid - Δ9-desaturase index) in the liver of rats fed the experimental diets increased.
CORRESPONDING AUTHOR
M. Czauderna   
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
 
CITATIONS (3):
1. Dietary Conjugated Linoleic Acid Alters Oxidative Stability and Alleviates Plasma Cholesterol Content in Meat of Broiler Chickens
Suriya Kumari Ramiah, Goh Yong Meng, Mahdi Ebrahimi
The Scientific World Journal
2. Effect of dietary conjugated linoleic acid and selenized yeast on the concentration of fatty acids and minerals in rats
Marian Czauderna, Jan Kowalczyk, Katarzyna Korniluk
Archives of Animal Nutrition
3. Effect of dietary conjugated linoleic acid supplementation on the technological quality of backfat of pigs
C. Bothma, A. Hugo, G. Osthoff, C.C. Joubert, J.C. Swarts, H.L. de Kock
Meat Science
ISSN:1230-1388