Despite the extensive evidence of health benefits associated with prebiotics, their effects on the haemostatic system remain largely unexplored. Hence, this study aimed to assess the influence of incorporating 1% (T1 diet) or 3% (T2 diet) native chicory inulin into the diet of nursery pigs on plasma proteome changes, focusing particularly on proteins associated with haemostasis and the complement system. Piglets were fed inulin-enriched diets from 10 days of age. Piglets were sacrificed at 50 days of age and blood samples were collected for liquid chromatography-mass spectrometry (LC-MS) analysis. Gene Ontology, KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway and proteinprotein interaction analyses of differentially expressed plasma proteins indicated that the direction of changes in proteins related to coagulation and fibrinolysis likely reflected a shift in haemostatic balance towards a more prothrombotic state. Quantitative changes in the expression of several other plasma proteins further supported the well-established anti-inflammatory, immunomodulatory and lipid lowering properties of inulin. In conclusion, inulin effectively coordinated the crosstalk between lipid metabolism and the inflammatory cascade, as reflected by the direction of changes in serum clusterin (Apo J), C-reactive protein and paraoxonase/arylesterase 1 expression levels