Effect of the addition of L-ascorbic acid in
megadoses to the diet on the morphology of liver
cells in rats

T. Ostaszewska; E. Sawosz; T. Niemiec; J. Skomiał; W. Bielecki

doi:10.22358/jafs/70295/2004

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Suppl. 2/2004 vol. 13

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SHORT COMMUNICATION

Effect of the addition of L-ascorbic acid in megadoses to the diet on the morphology of liver cells in rats

T. Ostaszewska ¹

E. Sawosz ²

T. Niemiec ²

J. Skomiał ²

W. Bielecki ³

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Warsaw Agricultural University, Division of lchtiobiology and Fisheries, Ciszewskiego 8, 02-786 Warsaw, Poland

Warsaw Agricultural University, Department of Animal Nutrition and Feed Science, Ciszewskiego 8, 02-786 Warsaw, Poland

Warsaw Agricultural University, Department of Clinical Science, Ciszewskiego 8, 02-786 Warsaw, Poland

Publication date: 2004-09-16

Corresponding author

E. Sawosz

Warsaw Agricultural University, Department of Animal Nutrition and Feed Science, Ciszewskiego 8, 02-786 Warsaw, Poland

J. Anim. Feed Sci. 2004;13(Suppl. 2):47-50

DOI: https://doi.org/10.22358/jafs/70295/2004

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KEYWORDS

rats

L-ascorbic acid

hepatocyte

pathomorphology

ABSTRACT

The aim of the study was to determine the effect of megadoses of L-ascorbic acid, as a dietary supplement for rats, on the morphological status of the liver. Forty małe rats were divided into 4 groups and fed mixtures that were supplemented with ascorbic acid in the following ąuantities in the particular groups (in % of the mixtures): I, 0.0; II, 0.3; III, 0.6; and IV, 0.9. The results showed that L-ascorbic acid supplemented to the mixtures at a level of 0.9% caused necrotic damage of hepatocytes.

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