ORIGINAL PAPER
The molecular mechanism of fat accumulation changes in Black-Bone chickens with different energy intakes
R. L. Qi 1,   C. Sun 1  
,   H. L. Yang 1,   X. Zhao 1,   Z. Tao 1
 
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Northwest A & F University, College of Animal Science and Technology, Yangling 712100, P.R. China
CORRESPONDING AUTHOR
C. Sun   

Northwest A & F University, College of Animal Science and Technology, Yangling 712100, P.R. China
Publication date: 2012-06-19
 
J. Anim. Feed Sci. 2012;21(2):361–371
 
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ABSTRACT
To investigate the molecular mechanism by which diets of different energy levels alter fat accumulation, 120 Black-Bone chickens were divided into 3 groups and fed diets with varying energy levels for six weeks (low: 3.02 Mcal/kg, moderate: 3.22 Mcal/kg, high: 3.42 Mcal/kg). The high-energy diet increased the concentration of blood lipids. Furthermore, high-energy intake inhibited the activities of several serum lipases. Histological sections showed over-synthesis of lipids in the livers of chickens fed high-energy diets. Data from western blotting and PCR analyses indicated that key factors for lipogenesis, regulatory transcription factors and fatty acid transporters, were up-regulated, while key factors for lipolysis were down-regulated. Chickens fed low-energy diets showed opposite results. In conclusion, varying energy levels of diets affect fat accumulation in Black-Bone chickens through changed expression of metabolic regulators.
ISSN:1230-1388