0.917
IF5
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IF
Q2
JCR
0.90
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SJR
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MNiSW
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ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

The effect of a high-fat diet on redox homeostasis indicators and nonspecifc immunity in rats

E. Sawosz 1  ,  
A. Winnicka 2,  
W. Kluciński 2,  
J. Skomiał 1, 3,  
 
1
Warsaw Agricultural University, Department of Animal Nutrition and Feed Science, Ciszewskiego 8, 02-786 Warszawa, Poland
2
Warsaw Agricultural University, Department of Clinical Diseases, Ciszewskiego 8, 02-786 Warszawa, Poland
3
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
J. Anim. Feed Sci. 2004;13(2):341–351
Publish date: 2004-04-09
KEYWORDS:
ABSTRACT:
Growing Wistar rats (30 animals) were divided into 3 groups of 10 each and fed semisynthetic diets: control (C), high-fat (67%) containing soyabean oil (O) or lard (L). After 5 weeks the animals were anesthetized and blood was sampled for analysis of nonspecific immunity indicators, antioxidant enzymatic activity, and blood count. Diet L (lard) led to increased activity of stimulated neutrophils and monocytes. The oxidative burst of neutrophils, activated by E. coli, was stimulated by the consumption of an energy-dense diet (lard and oil vs control), whereas the number of phagocytosing cells with reactive oxygen species was smaller in the group of animals fed lard. Moreover, disorders of redox homeostasis were found; diminished superoxide dismutase activity was accompanied by increased GPx activity in rats receiving a high level of dietary fat.
CORRESPONDING AUTHOR:
E. Sawosz   
Warsaw Agricultural University, Department of Animal Nutrition and Feed Science, Ciszewskiego 8, 02-786 Warszawa, Polan
ISSN:1230-1388