1.054
IF5
1.150
IF
Q3
JCR
1.7
CiteScore
0.396
SJR
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SJR
40
MNiSW
148.75
ICV
ORIGINAL PAPER
 
CC-BY 4.0
 
 

Mutagen-induced chromosome instability in farm animals

B. Danielak-Czech 1  ,  
 
1
Department of Immuno- and Cytogenetics, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland
J. Anim. Feed Sci. 2004;13(2):257–267
Publication date: 2004-04-09
KEYWORDS
ABSTRACT
The frequencies of spontaneous and in vitro mutagen-induced unstable chromosomal lesions were compared in the groups of subfertile cows, ewes and sows (test groups) as well as the animals without any reproductive disturbances (control groups). The mean percentage of 5-azacytidine- and bromodeoxyuridine-induced defects differed statistically between the test and control groups (P≤0.01 in cattle, P≤0.05 in sheep and pigs). In the groups of animals with reproductive problems the number of defects observed in some chromosomes exceeded the expected values (calculated according to the relative chromosome length), but only in the case of X chromosome differed at the level of statistical significance. Moreover, the groups of cows analysed differed significantly as regards the number of chromatid breaks/gaps at the Xq2.4 and Xq3.1 fragile sites. The excessive chromosome instability in subfertile farm animals, particularly the X-specific loci, may result in inappropriate expression of genes determining reproductive traits as well as in the increased rate of aneuploid germ cells related to prenatal and perinatal mortality.
CORRESPONDING AUTHOR
B. Danielak-Czech   
Department of Immuno- and Cytogenetics, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice, Poland
 
CITATIONS (11):
1. Effects of 5-azacytidine on lymphocyte-metaphases of Creole cows carrying the rob(1;29)
R. Artigas, W. Iriarte, A. Iriarte, M. de Bethencourt, S. Llambí, A. Postiglioni
Research in Veterinary Science
2. Chromosome Instability in a Calf with Amelia of Thoracic Limbs
I. Szczerbal, T. Stefaniak, A. Dubiel, J. Siembieda, W. Nizanski, M. Switonski
Veterinary Pathology
3. Molecular approach of the fragile chromosomal region Xq31-34 in cattle (Bos taurus) by microdissection and DOP-PCR
S. Llambí, M.V. Arruga
Arquivo Brasileiro de Medicina Veterinária e Zootecnia
4. Assessment of chromosome instability in geese (Anser anser)
Ewa Wójcik, Elżbieta Smalec
Canadian Journal of Animal Science
5. Identification of chromosome instability in Japanese quail (Coturnix japonica)
E. Wójcik, K. Andraszek, E. Smalec, S. Knaga, A. Witkowski
British Poultry Science
6. A new case of reciprocal translocation t(10;13)(q16;q21) diagnosed in an AI boar
Barbara Danielak-Czech, Ewa Słota
Journal of Applied Genetics
7. Analysis of chromatin instability of somatic cells in sheep
Ewa Wójcik, Małgorzata Szostek, Elżbieta Horoszewicz, Emilia Kot, Sałuch Sebastian, Elżbieta Smalec, J. Plaizier
Canadian Journal of Animal Science
8. Assessment of genome stability in various breeds of cattle
Ewa Wójcik, Małgorzata Szostek, Juan Loor
PLOS ONE
9. Heterosome X premutation structural changes associated with fertility of Romanov sheep
Barbara Danielak-Czech, Anna Kozubska-Sobocińska, Marek Babicz, Barbara Rejduch
Annales UMCS, Zootechnica
10. Assessment of chromosome stability in boars
Ewa Wójcik, Agnieszka Sokół, Robert Sobol
PLOS ONE
11. Breeding and Economic Aspects of Cytogenetic Screening Studies of Pigs Qualified for Reproduction
Barbara Danielak-Czech, Anna Kozubska-Sobocińska, Grzegorz Smołucha, Marek Babicz
Animals
ISSN:1230-1388